US4428963A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel thiophene derivatives
Assignee: Hoffmann La Roche Inc
•
Filing: 1983-03-10
•
Granted: 1984-01-31
•
Expires: 2003-03-10
Abstract
Abstract Thiophene derivatives having utility as blood lipid lowering agents and as antiobesity agents are disclosed.
Inventors
- 👤 Pasquale N. Confalone
- 👤 Giacomo Pizzolato
- 👤 Milan R. Uskokovic
- 👤 Marianne Rouge
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:57
CPC Classifications
C; C07; C07D; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/38; A; A61; A61K; A61K31/00; A61K31/33; A61K31/38; A61K31/381
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
65 words
A process for reducing blood lipid levels in warm blooded animals which comprises administering an amount of a compound of the formula: ##STR9## wherein R is lower alkyl; R 2 is hydrogen, hydroxy, lower alkoxy, or amino; R 3 and R 4 individually are lower alkyl, aryl, aralkyl or hydrogen; or a pharmaceutically acceptable salt thereof, in an amount effective for reducing blood lipid levels.
Claim 2
Dependent Claim
65 words
A process for reducing blood lipid levels in warm blooded animals which comprises administering an amount of a compound of the formula: ##STR9## wherein R is lower alkyl; R 2 is hydrogen, hydroxy, lower alkoxy, or amino; R 3 and R 4 individually are lower alkyl, aryl, aralkyl or hydrogen; or a pharmaceutically acceptable salt thereof, in an amount effective for reducing blood lipid levels.
Claim 3
Dependent Claim
16 words
The process of claim 1 wherein said compound is: ##STR10## or a pharmaceutically acceptable salt thereof.
Claim 4
Independent Claim
68 words
A method for reducing body fat in warm-blooded animals comprising administering a compound of the formula: ##STR11## wherein R is lower alkyl; R 2 is hydrogen, hydroxy, lower alkoxy, or amino; R 3 and R 4 , which may be the same or different, are lower alkyl, aryl, aralkyl, acyl and hydrogen; or a pharmaceutically acceptable salt thereof, in an amount which is effective as an antiobesity agent.
Claim 5
Independent Claim
68 words
A method for reducing body fat in warm-blooded animals comprising administering a compound of the formula: ##STR11## wherein R is lower alkyl; R 2 is hydrogen, hydroxy, lower alkoxy, or amino; R 3 and R 4 , which may be the same or different, are lower alkyl, aryl, aralkyl, acyl and hydrogen; or a pharmaceutically acceptable salt thereof, in an amount which is effective as an antiobesity agent.
Claim 6
Dependent Claim
16 words
The method of claim 3 wherein the compound is ##STR12## or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
14 words
The process of claim 2 wherein the compound is 4-amino-5-ethyl-3-thiophene carboxylic acid methyl ester.
Claim 8
Dependent Claim
17 words
The process of claim 2 wherein the pharmaceutically acceptable salt is 4-amino-5-ethyl-3-thiophene carboxylic acid methyl ester hydrochloride.
Claim 9
Dependent Claim
12 words
The process of claim 1 wherein the compound is 4-amino-5-ethyl-3-thiophene carboxylic acid.
Claim 10
Dependent Claim
14 words
The method of claim 4 wherein the compound is 4-amino-5-ethyl-3-thiophene carboxylic acid methyl ester.
Claim 11
Dependent Claim
17 words
The method of claim 4 wherein the pharmaceutically acceptable salt is 4-amino-5-ethyl-3-thiophene carboxylic acid methyl ester hydrochloride.
Claim 12
Dependent Claim
12 words
The method of claim 3 wherein the compound is 4-amino-5-ethyl-3-thiophene carboxylic acid.
References Cited (Backward Citations)
US3076817A
Cited
GB574279A
Cited
US2502421A
Cited
US2443598A
Cited
US2502423A
Cited
US2502424A
Cited
GB608969A
Cited
GB837086A
Cited
GB1133850A
Cited
US3445473A
Cited
US3855243A
Cited
GB1278084A
Cited
US3828001A
Cited
US3823161A
Cited
US3929833A
Cited
US3795681A
Cited
US3903289A
Cited
US3963750A
Cited
US3978084A
Cited
US4317915A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-30 | 1987-08-01 | 1988-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-30 | 1991-08-01 | 1992-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-30 | 1995-08-01 | 1996-01-31 | $7700.00 | Window Closed / Lapsed |