Patent US4428939A successfully refreshed from Google Patents.
US4428939A
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Collagen inhibiting compositions and processes for manufacturing and using same
Assignee: COLLEGE OF MEDICINE AND DENTISTRY OF NEW JERSEY
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Filing: 1981-10-16
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Granted: 1984-01-31
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Expires: 2001-10-16
Abstract
Abstract There is disclosed the use of a collagen inhibiting composition including in polymeric form select analogs of proline and processes for the manufacture and use of such a collagen-inhibiting composition to reduce scar tissue formation.
Inventors
- 👤 Darwin J. Prockop
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 12:23
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/785; A61P; A61P17/00; A61P43/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
125 words
A composition for the control of the cellular synthesis of collagen fibers in animals, which comprises a proline analog in polymeric form selected from the group, consisting of L-azetidine-2-carboxylic acid; cis-4-hydroxy-L-proline; 3,4-dehydro-L-proline; cis-4-hydroxy-L-proline; cis-4-chloro-L-proline; laevo and cis isomers of compounds of the general structural formula ##STR5## wherein R is OH, Cl, F, NH 2 , CH 3 , OC(O)CH 3 , OC(O)CH 2 CH 3 , SH, SCH 3 , OCH 3 , ONO 2 , OSO 3 H, H 2 PO 4 , or COOH; L-pipecolic acid; 1,2,3,6-tetrahydro-L-picolinic acid; 1,2,3,4-tetrahydro-L-picolinic acid; 1,4,5,6-tetrahydro-L-picolinic acid; 1,2,5,6-tetrahydro-L-picolinic acid; 1,2-dihydro-L-picolinic acid; laevo isomers of the compound of the general structural formula ##STR6## where X is N, S or O; or mixture thereof and a pharmaceutically acceptable carrier therefor.
Claim 2
Dependent Claim
125 words
A composition for the control of the cellular synthesis of collagen fibers in animals, which comprises a proline analog in polymeric form selected from the group, consisting of L-azetidine-2-carboxylic acid; cis-4-hydroxy-L-proline; 3,4-dehydro-L-proline; cis-4-hydroxy-L-proline; cis-4-chloro-L-proline; laevo and cis isomers of compounds of the general structural formula ##STR5## wherein R is OH, Cl, F, NH 2 , CH 3 , OC(O)CH 3 , OC(O)CH 2 CH 3 , SH, SCH 3 , OCH 3 , ONO 2 , OSO 3 H, H 2 PO 4 , or COOH; L-pipecolic acid; 1,2,3,6-tetrahydro-L-picolinic acid; 1,2,3,4-tetrahydro-L-picolinic acid; 1,4,5,6-tetrahydro-L-picolinic acid; 1,2,5,6-tetrahydro-L-picolinic acid; 1,2-dihydro-L-picolinic acid; laevo isomers of the compound of the general structural formula ##STR6## where X is N, S or O; or mixture thereof and a pharmaceutically acceptable carrier therefor.
Claim 3
Dependent Claim
13 words
The composition as defined in claim 1 wherein said proline analog is cis-4-hydroxy-L-proline.
Claim 4
Independent Claim
32 words
A method for the synthesis of polymer of any of the proline analogs defined in claims 1 or 2 wherein the proline analogs are linked through ester bonds to a polypeptide chain.
Claim 5
Independent Claim
45 words
A method for the control of the cellular synthesis of collagen fibers in animals in an area where scar tissue formation can occur, which comprises the topical application of an effective amount of the composition as defined in claims 1 or 2 in said area.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-30 | 1987-08-01 | 1988-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-30 | 1991-08-01 | 1992-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-30 | 1995-08-01 | 1996-01-31 | $7700.00 | Window Closed / Lapsed |