Patent US4425319A successfully refreshed from Google Patents.
US4425319A
Expired / Lapsed
US
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Radioactive diagnostic agent and non-radioactive carrier therefor
Assignee: Nihon Medi Physics Co Ltd
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Filing: 1981-02-20
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Granted: 1984-01-10
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Expires: 2001-02-20
Abstract
Abstract A radioactive diagnostic agent which comprises deferoxamine, and a physiologically active compound and a radioactive metallic element chemically connected thereto with or without intervention of any other chemical bonding, which is characteristic in having a high stability even after being administered into a human body and showing substantially the same behavior in a human body as said physiologically active compound itself.
Inventors
- 👤 Akira Yokoyama
- 👤 Yoshiro Omomo
- 👤 Hisashi Tanaka
- 👤 Hideo Saji
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 21:17
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
42 words
A radioactive metallic element-labeled, physiologically active substance-combined compound, which consists of deferoxamine, an organic physiologically active substance chemically bonded thereto with or without intervention of any other chemical bonding and a radioactive metallic element bonded to said deferoxamine through a chelating bond.
Claim 2
Dependent Claim
42 words
A radioactive metallic element-labeled, physiologically active substance-combined compound, which consists of deferoxamine, an organic physiologically active substance chemically bonded thereto with or without intervention of any other chemical bonding and a radioactive metallic element bonded to said deferoxamine through a chelating bond.
Claim 3
Dependent Claim
40 words
The compound according to claim 1, wherein the physiologically active substance has a carboxyl group and is bonded to deferoxamine by forming a --CONH-- linkage between the carboxyl group in the physiologically active substance and the amino group in deferoxamine.
Claim 4
Dependent Claim
79 words
The compound according to claim 1, wherein the physiologically active substance has an amino group and is bonded to deferoxamine with intervention of a compound having at least two carbonyl groups by forming a >C═N-- linkage between the amino group in the physiologically active substance and an carboxyl group in said compound and also between the amino group in deferoxamine and another carbonyl group in said compound, the >C═N-- linkage being thereafter converted into a >CHNH-- linkage by reduction.
Claim 5
Dependent Claim
15 words
The compound according to claim 1, wherein the physiologically active substance is human serum albumin.
Claim 6
Dependent Claim
13 words
The compound according to claim 1, wherein the physiologically active substance is urokinase.
Claim 7
Dependent Claim
13 words
The compound according to claim 1, wherein the physiologically active substance is fibrinogen.
Claim 8
Dependent Claim
14 words
The compound according to claim 1, wherein the radioactive metallic element is 67 Ga.
Claim 9
Dependent Claim
14 words
The compound according to claim 1, wherein the radioactive metallic element is 111 In.
Claim 10
Dependent Claim
27 words
A physiologically active substance-combined compound, which consists of deferoxamine and an organic physiologically active substance chemically bonded thereto with or without intervention of any other chemical bonding.
Claim 11
Dependent Claim
27 words
A physiologically active substance-combined compound, which consists of deferoxamine and an organic physiologically active substance chemically bonded thereto with or without intervention of any other chemical bonding.
Claim 12
Dependent Claim
40 words
The compound according to claim 9, wherein the physiologically active substance has a carboxyl group and is bonded to deferoxamine by forming a --CONH-- linkage between the carboxyl group in the physiologically active substance and the amino group in deferoxamine.
Claim 13
Dependent Claim
79 words
The compound according to claim 9, wherein the physiologically active substance has an amino group and is bonded to deferoxamine with intervention of a compound having at least two carbonyl groups by forming a >C═N-- linkage between the amino group in the physiologically active substance and an carboxyl group in said compound and also between the amino group in deferoxamine and another carbonyl group in said compound, the >C═N-- linkage being thereafter converted into a >CHNH-- linkage by reduction.
Claim 14
Dependent Claim
37 words
A physiologically active substance-combined compound comprising deferoxamine and a physiologically active substance selected from the group consisting of proteins, antibiotics, hormones, saccharides and fatty acids chemically bonded thereto with or without intervention of any other chemical bonding.
Claim 15
Dependent Claim
37 words
A physiologically active substance-combined compound comprising deferoxamine and a physiologically active substance selected from the group consisting of proteins, antibiotics, hormones, saccharides and fatty acids chemically bonded thereto with or without intervention of any other chemical bonding.
Claim 16
Dependent Claim
21 words
The compound according to claim 12, and further comprising a radioactive metallic element bonded to said deferoxamine through a chelating bond.
Claim 17
Dependent Claim
14 words
The compound according to claim 12, wherein said physiologically active substance is a protein.
Claim 18
Dependent Claim
14 words
The compound according to claim 12, wherein said physiologically active substance is an antibiotic.
Claim 19
Dependent Claim
14 words
The compound according to claim 12, wherein said physiologically active substance is a hormone.
Claim 20
Dependent Claim
14 words
The compound according to claim 12, wherein said physiologically active substance is a saccharide.
Claim 21
Dependent Claim
15 words
The compound according to claim 12, wherein said physiologically active substance is a fatty acid.
Claim 22
Dependent Claim
22 words
The compound according to claim 12, wherein said physiologically active substance has an active carboxyl group which is bonded with said deferoxamine.
Claim 23
Dependent Claim
22 words
The compound according to claim 12, wherein said physiologically active substance has an active amino group which is bonded with said deferoxamine.
Claim 24
Dependent Claim
27 words
A method for diagnosing physiological abnormalities which comprises administering to a patient an effective imaging amount of the compound according to claim 1 and imaging said abnormality.
Claim 25
Dependent Claim
27 words
A method for diagnosing physiological abnormalities which comprises administering to a patient an effective imaging amount of the compound according to claim 13 and imaging said abnormality.
References Cited (Backward Citations)
US3961038A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-09 | 1987-07-11 | 1988-01-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-09 | 1991-07-11 | 1992-01-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-09 | 1995-07-11 | 1996-01-10 | $7700.00 | Window Closed / Lapsed |