Patent US707525A successfully refreshed from Google Patents.
Patent US4424216A successfully refreshed from Google Patents.
US4424216A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for the reduction of mucin viscosity
Assignee: Rockefeller University
•
Filing: 1979-07-31
•
Granted: 1984-01-03
•
Expires: 1999-07-31
Abstract
Abstract A method for reducing mucin viscosity which comprises administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce free sulfhydryl groups.
Inventors
- 👤 Anthony Cerami
- 👤 Nina F. Tabachnik
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:59
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/095; A61P; A61P11/00; A61P11/10
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
37 words
A method for reducing mucin viscosity in humans which comprises administering to said human effective a pharmaceutically effective dose of one or more compounds having protected sulfhydryl groups which metabolize in vivo to produce free sulfhydryl groups.
Claim 2
Independent Claim
37 words
A method for reducing mucin viscosity in humans which comprises administering to said human effective a pharmaceutically effective dose of one or more compounds having protected sulfhydryl groups which metabolize in vivo to produce free sulfhydryl groups.
Claim 3
Dependent Claim
163 words
The method of claim 1, wherein the compound containing protected sulfhydryl groups is selected from the group consisting of: (H 2 NCOCH 2 CH 2 NHCH 2 CH 2 S-) 2 H 2 NCOCH 2 CH 2 NHCH 2 CH 2 SSO 3 H H 2 NCOCH 2 CH 2 NHCH 2 CH 2 SPO 3 H 2 H 2 N(CH 2 ) 3 NHCH 2 CH 2 SSO 3 H (H 2 N(CH 2 ) 3 NHCH 2 CH 2 S-) 2 CH 3 (CH 2 ) 9 NHCH 2 CH 2 SSO 3 H CH 3 (CH 2 ) 9 NHCH 2 CH 2 SPO 3 H 2 (CH 3 (CH 2 ) 9 NHCH 2 CH 2 S-) 2 H 2 NCH 2 CH 2 SPO 3 H 2 H 2 N(CH 2 ) 5 NH(CH 2 ) 2 SPO 3 H 2 H 2 N(CH 2 ) 3 NH(CH 2 )SPO 3 H 2 and their pharmaceutically acceptable salts.
Claim 4
Independent Claim
17 words
The method of claims 1 or 2, wherein the effective dose is from 1 to 100 mg/kg/day.
Claim 5
Dependent Claim
17 words
The method of claim 3, wherein said effective dose is from about 5 to about 30 mg/kg/day.
Claim 6
Dependent Claim
28 words
The method of claim 1, wherein said compound containing protected sulfhydryl group has the formula: H 2 N(CH 2 ) 3 NH(CH 2 )SPO 3 H 2 .
Claim 7
Independent Claim
98 words
A method for reducing mucin viscosity in humans which comprises administering to said human a pharmaceutically effective dose of at least one compound selected from the group consisting of: H 2 NCOCH 2 CH 2 NHCH 2 CH 2 SPO 3 H 2 CH 3 (CH 2 ) 9 NHCH 2 CH 2 SPO 3 H 2 H 2 NCH 2 CH 2 SPO 3 H 2 H 2 N(CH 2 ) 5 NH(CH 2 ) 2 SPO 3 H 2 H 2 N(CH 2 ) 3 NH(CH 2 )SPO 3 H 2 and their pharmaceutically acceptable salts.
Claim 8
Independent Claim
98 words
A method for reducing mucin viscosity in humans which comprises administering to said human a pharmaceutically effective dose of at least one compound selected from the group consisting of: H 2 NCOCH 2 CH 2 NHCH 2 CH 2 SPO 3 H 2 CH 3 (CH 2 ) 9 NHCH 2 CH 2 SPO 3 H 2 H 2 NCH 2 CH 2 SPO 3 H 2 H 2 N(CH 2 ) 5 NH(CH 2 ) 2 SPO 3 H 2 H 2 N(CH 2 ) 3 NH(CH 2 )SPO 3 H 2 and their pharmaceutically acceptable salts.
Claim 9
Independent Claim
50 words
A method for reducing mucin viscosity in mammals which comprises administering to said mammal a pharmaceutically effective dose of at least one compound having a protective sulfhydryl group which metabolizes in vivo to produce free sulfhydryl groups and which is selected from the group consisting of thiosulfates, thiophosphates, and disulfides.
Claim 10
Independent Claim
50 words
A method for reducing mucin viscosity in mammals which comprises administering to said mammal a pharmaceutically effective dose of at least one compound having a protective sulfhydryl group which metabolizes in vivo to produce free sulfhydryl groups and which is selected from the group consisting of thiosulfates, thiophosphates, and disulfides.
Claim 11
Dependent Claim
55 words
The method of claim 7, wherein said compounds are selected from the group consisting of aminoalkylthiosulfuric acids, aminoalkylphosphorothioates, thiosulfatoalkylamines, phenalkylaminoalkylthiosulfuric acids, hydroxyalkylaminoalkylthiosulfuric acids, hydroxyaminoalkylphosphorothioates, alkoxyalkylaminoalkylthiosulfuric acids, cycloalkyloxyaminoalkylthiosulfuric acids, phenoxyalkylaminoalkylthiosulfuric acids, cycloalkylaminoalkylthiosulfuric acids, cycloalkylalkylaminoalkylphosphorothioates, cycloalkylalkylaminoalkyldisulfides, phenoxyalkylaminoethyldisulfides, hydroxyalkylaminoalkyldisulfides, alkylamidiniumthiosulfates, acetamidine derivatives containing a blocked sulfhydryl group, arylalkylamidiniumthiosulfates, aminoalkylaminoalkylphosphorothioates, quinolyloxyalkylaminoalkylthiosulfuric acids, pyridyloxyalkylaminoalkylthiosulfuric acids, phenoxy- and phenylthioalkylamidiniumthiosulfates and cycloalkylamidiniumthiosulfates.
References Cited (Backward Citations)
US3892824A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-02 | 1987-07-04 | 1988-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-02 | 1991-07-04 | 1992-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-02 | 1995-07-04 | 1996-01-03 | $7700.00 | Window Closed / Lapsed |