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US4423149A
Expired / Lapsed
US
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Process for the production of D-glucosone
Assignee: Novartis Vaccines and Diagnostics Inc
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Filing: 1981-10-15
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Granted: 1983-12-27
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Expires: 2001-10-15
Abstract
Abstract A process is described for the production of D-glucosone from glucose. An aqueous solution of glucose is converted substantially completely to D-glucosone by an enzymatic oxidation while removing or utilizing co-produced hydrogen peroxide. D-glucosone is a useful intermediate product which may then be converted to a desired end product.
Inventors
- 👤 William F. Amon, Jr.
- 👤 John Geigert
- 👤 Saul L. Neidleman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:07
CPC Classifications
C; C07; C07H; C07H3/00; C07H3/08; C12; C12P; C12P19/00; C12P19/02; C12P7/00; C12P7/40; C12P7/58
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
44 words
A method for making D-glucosone from glucose, comprising, providing an aqueous solution of glucose, and converting at least about 95% of the glucose in solution to D-glucosone in solution by enzymatic oxidation with a cell free enzyme while removing or utilizing co-produced hydrogen peroxide.
Claim 2
Independent Claim
44 words
A method for making D-glucosone from glucose, comprising, providing an aqueous solution of glucose, and converting at least about 95% of the glucose in solution to D-glucosone in solution by enzymatic oxidation with a cell free enzyme while removing or utilizing co-produced hydrogen peroxide.
Claim 3
Dependent Claim
16 words
A method according to claim 1 wherein the D-glucosone is further converted to an end product.
Claim 4
Dependent Claim
23 words
A method according to claim 2 wherein the D-glucosone in solution is recovered as a syrup and is resolubilized in an organic solvent.
Claim 5
Dependent Claim
12 words
A method according to claim 2 wherein the end product is D-fructose.
Claim 6
Dependent Claim
13 words
A method according to claim 2 wherein the end product is 2-keto-D-gluconic acid.
Claim 7
Dependent Claim
15 words
A method according to claim 1 wherein the enzyme comprises an oxidoreductase having glucose-2-oxidase activity.
Claim 8
Dependent Claim
25 words
A method according to claim 6 wherein the enzyme is selected from the group consisting of glucose-2-oxidase from Aspergillus oryzae and pyranose-2-oxidase from Polyporus obtusus.
Claim 9
Dependent Claim
11 words
A method according to claim 6 wherein the enzyme is immobilized.
Claim 10
Dependent Claim
17 words
A method according to claim 1 wherein the hydrogen peroxide is removed by enzymatic decomposition by catalase.
Claim 11
Dependent Claim
15 words
A method according to claim 1 wherein the hydrogen peroxide is utilized in a co-process.
Claim 12
Independent Claim
51 words
A method for making D-glucosone from glucose, comprising, providing an aqueous solution of glucose, and converting at least about 95% of the glucose in solution to D-glucosone in solution by utilizing an immobilized cell free oxidoreductase enzyme having or utilizing co-produced hydrogen peroxide, and recovering the D-glucosone in substantially pure form.
Claim 13
Independent Claim
51 words
A method for making D-glucosone from glucose, comprising, providing an aqueous solution of glucose, and converting at least about 95% of the glucose in solution to D-glucosone in solution by utilizing an immobilized cell free oxidoreductase enzyme having or utilizing co-produced hydrogen peroxide, and recovering the D-glucosone in substantially pure form.
Claim 14
Dependent Claim
14 words
A method according to claim 11 which is carried out in a column reactor.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-26 | 1987-06-27 | 1987-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-26 | 1991-06-27 | 1991-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-26 | 1995-06-27 | 1995-12-27 | $7700.00 | Window Closed / Lapsed |