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US4422970A
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Method of synthesis of 1-dodecylazacycloheptan-2-one
Assignee: Whitby Research Inc
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Filing: 1982-05-20
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Granted: 1983-12-27
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Expires: 2002-05-20
Abstract
Abstract In a method of synthesis of 1-substituted azacycloalkan-2-ones with primary alkyl halides and aralkyl halides as alkylating agents, the improvement comprising carrying out the N-alkylation in the presence of a phase transfer catalyst having the structural formula ##STR1## where X is suitable anion; and R 1 , R 2 , R 3 and R 4 are each alkyl or aralkyl groups having 1-18 carbon atoms, or R 2 , R 3 and R 4 can form a part of a heterocyclic ring, with the proviso that the combined total of carbon atoms is between 16 and 40.
Inventors
- 👤 Vithal J. Rajadhyaksha
- 👤 James V. Peck
- 👤 Gevork Minaskanian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 06:21
CPC Classifications
C; C07; C07D; C07D225/00; C07D225/02; C07D223/00; C07D223/02; C07D223/06; C07D223/08; C07D223/10
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
24 words
The method of synthesis of 1-dodecylazacycloheptan-2-one comprising reacting under aqueous conditions azacycloheptan-2-one with 1-bromo-dodecane in the presence of a catalytic amount of tricaprylylmethyl-ammonium chloride.
Claim 2
Independent Claim
24 words
The method of synthesis of 1-dodecylazacycloheptan-2-one comprising reacting under aqueous conditions azacycloheptan-2-one with 1-bromo-dodecane in the presence of a catalytic amount of tricaprylylmethyl-ammonium chloride.
Claim 3
Independent Claim
41 words
The method of synthesis of 1-dodecylazacycloheptan-2-one comprising reacting under aqueous conditions azacycloheptan-2-one with a dodecyl-containing alkylating agent in the presence of a phase transfer catalyst selected from the group consisting of tricaprylylmethylammonium chloride tetrabutylammonium hydrogen sulfate, tetraheptylammonium chloride and didodecyldimethylammonium bromide.
Claim 4
Independent Claim
41 words
The method of synthesis of 1-dodecylazacycloheptan-2-one comprising reacting under aqueous conditions azacycloheptan-2-one with a dodecyl-containing alkylating agent in the presence of a phase transfer catalyst selected from the group consisting of tricaprylylmethylammonium chloride tetrabutylammonium hydrogen sulfate, tetraheptylammonium chloride and didodecyldimethylammonium bromide.
Claim 5
Dependent Claim
13 words
The method of claim 2 wherein the dodecyl- containing alkylating agent is 1-halo-dodecane.
Claim 6
Dependent Claim
13 words
The method of claim 2 wherein the phase transfer catalyst is tricaprylylmethylammonium chloride.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-26 | 1987-06-27 | 1987-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-26 | 1991-06-27 | 1991-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-26 | 1995-06-27 | 1995-12-27 | $7700.00 | Window Closed / Lapsed |