US4421738A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sugar-coated tablet containing fat-soluble pharmaceutical material
Assignee: Eisai Co Ltd
•
Filing: 1982-03-18
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Granted: 1983-12-20
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Expires: 2002-03-18
Abstract
Abstract A sugar-coated tablet for medical use comprising a core containing low-melting fat-soluble pharmaceutical material and a sugar coating layer on said core, which is characterized by the feature that at least one water-soluble cellulose ether coating film is present between the core and the sugar-coating layer.
Inventors
- 👤 Satoshi Yamagiwa
- 👤 Yoshio Taguchi
- 👤 Masanori Kayano
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:51
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/28; A61K9/2886; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
119 words
A sugar-coated tablet, comprising: a core containing low-melting, fat-soluble, active pharmaceutical material; a continuous coating film formed in direct contact with and completely covering said core, said coating film consisting of a material selected from the group consisting of (a) a pharmacologically acceptable water-soluble cellulose ether, (b) a mixture of two or more of said cellulose ethers and (c) a mixture of one or more of said cellulose ethers and a plasticizer therefor, said coating film being free of sugar; and a pharmacologically acceptable, sugar, coating layer over said film, said sugar layer being free of water-soluble cellulose ether, said film being effective to prevent migration of said active pharmaceutical material from said core to said sugar coating layer.
Claim 2
Dependent Claim
119 words
A sugar-coated tablet, comprising: a core containing low-melting, fat-soluble, active pharmaceutical material; a continuous coating film formed in direct contact with and completely covering said core, said coating film consisting of a material selected from the group consisting of (a) a pharmacologically acceptable water-soluble cellulose ether, (b) a mixture of two or more of said cellulose ethers and (c) a mixture of one or more of said cellulose ethers and a plasticizer therefor, said coating film being free of sugar; and a pharmacologically acceptable, sugar, coating layer over said film, said sugar layer being free of water-soluble cellulose ether, said film being effective to prevent migration of said active pharmaceutical material from said core to said sugar coating layer.
Claim 3
Dependent Claim
33 words
A sugar-coated tablet as claimed in claim 1 in which said cellulose ether is selected from the group consisting of methyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose, hydroxyethylmethyl cellulose and mixtures thereof.
Claim 4
Dependent Claim
16 words
A sugar-coated tablet as claimed in claim 1 in which said cellulose ether is hydroxypropyl cellulose.
Claim 5
Dependent Claim
26 words
A sugar-coated tablet as claimed in claim 1, claim 2 or claim 3, in which the thickness of said coating film is at least 0.02 mm.
Claim 6
Dependent Claim
27 words
A sugar-coated tablet as claimed in claim 1, claim 2 or claim 3, in which the thickness of said coating film is from 0.05 to 0.2 mm.
Claim 7
Dependent Claim
23 words
A sugar-coated tablet as claimed in claim 1, in which said pharmaceutical material has a melting point of not higher than 70° C.
Claim 8
Dependent Claim
16 words
A sugar-coated tablet as claimed in claim 6, in which said pharmaceutical material is Coenzyme Q.
Claim 9
Dependent Claim
56 words
A sugar-coated tablet as claimed in claim 1, consisting essentially of said core; said coating film; a layer of powder sugar in direct contact with and covering said coating film; a coloring layer in direct contact with and covering said powder sugar layer; and a wax film in direct contact with and covering said coloring layer.
References Cited (Backward Citations)
US2693436A
Cited
US2881085A
Cited
US2816062A
Cited
US2925365A
Cited
US3043747A
Cited
US3096248A
Cited
US3054724A
Cited
US3371015A
Cited
US3185626A
Cited
US3361631A
Cited
US3383236A
Cited
US3406031A
Cited
US3256111A
Cited
US3480468A
Cited
US3981984A
Cited
US4001390A
Cited
US4176175A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-19 | 1987-06-20 | 1987-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-19 | 1991-06-20 | 1991-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-19 | 1995-06-20 | 1995-12-20 | $7700.00 | Window Closed / Lapsed |