US4176175A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sugar-coated solid dosage forms
Assignee: Shin-Etsu Chemical Co Ltd
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Filing: 1977-06-06
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Granted: 1979-11-27
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Expires: 1997-06-06
Abstract
Abstract The sugar-coated solid dosage forms have improved disintegrability even in a neutral medium after prolonged storage, with sugar-coating layers having excellent mechanical strengths. The coating layer that is in direct contact with the surface of the solid dosage form contains a water-insoluble hydroxypropyl cellulose with a relatively low content of hydroxypropoxy groups, say, from 4 to 16% by weight. The hydroxypropyl cellulose is used by being suspended in the coating syrup or mixed in the dusting powder for purposes of subcoating. It is also possible to use the hydroxypropyl cellulose in the form of suspension to form a smoothing coat.
Inventors
- 👤 Hideyuki Maekawa
- 👤 Kinzaburo Noda
- 👤 Noboru Hoshi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 13:32
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866; A61K9/282; A61K9/2826
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
47 words
A sugar-coated solid dosage form comprising at least one coating layer formed in direct contact with the surface of the solid dosage form and containing from 0.5 to 25% by weight of a hydroxypropylcellulose having hydroxypropoxy groups in an amount ranging from 4 to 16% by weight.
Claim 2
Dependent Claim
47 words
A sugar-coated solid dosage form comprising at least one coating layer formed in direct contact with the surface of the solid dosage form and containing from 0.5 to 25% by weight of a hydroxypropylcellulose having hydroxypropoxy groups in an amount ranging from 4 to 16% by weight.
Claim 3
Dependent Claim
27 words
The sugar-coated solid dosage form as claimed in claim 1 wherein the amount of the hydroxypropoxy groups in the hydroxypropylcellulose ranges from 7 to 13% by weight.
Claim 4
Dependent Claim
27 words
The sugar-coated solid dosage form as claimed in claim 1 wherein the content of the hydroxypropylcellulose in the coating layer is from 1 to 10% by weight.
Claim 5
Dependent Claim
19 words
The sugar-coated solid dosage form as claimed in claim 1 wherein the hydroxypropylcellulose is contained in a subcoating layer.
Claim 6
Dependent Claim
26 words
The sugar-coated solid dosage form as claimed in claim 1 wherein the hydroxypropylcellulose is contained in a smoothing layer in the absence of a subcoating layer.
Claim 7
Dependent Claim
20 words
The sugar-coated solid dosage form as claimed in claim 1 wherein the hydroxypropylcellulose is contained in subcoating and smoothing layers.
Claim 8
Dependent Claim
28 words
The sugar-coated solid dosage form as claimed in claim 1 wherein the hydroxypropylcellulose has a particle size that more than 95% pass through a 100-mesh Tyler Standard screen.
Claim 9
Independent Claim
76 words
A method for providing a layer of sugar coating on a solid dosage form which comprises adding a hydroxypropylcellulose having hydroxypropoxy groups in an amount ranging from 4 to 16% by weight to a coating composition and coating the solid dosage form with the coating composition whereby to form a layer of sugar coating containing from 0.5 to 25% by weight of the hydroxypropyl cellulose in direct contact with the surface of the solid dosage form.
Claim 10
Independent Claim
76 words
A method for providing a layer of sugar coating on a solid dosage form which comprises adding a hydroxypropylcellulose having hydroxypropoxy groups in an amount ranging from 4 to 16% by weight to a coating composition and coating the solid dosage form with the coating composition whereby to form a layer of sugar coating containing from 0.5 to 25% by weight of the hydroxypropyl cellulose in direct contact with the surface of the solid dosage form.
Claim 11
Dependent Claim
25 words
The method as claimed in claim 8 wherein the hydroxypropylcellulose has a particle size that more than 95% pass through a 100-mesh Tyler Standard screen.
Claim 12
Dependent Claim
17 words
The method as claimed in claim 8 wherein the coating composition is a sugar syrup for subcoating.
Claim 13
Dependent Claim
17 words
The method as claimed in claim 8 wherein the coating composition is a dusting powder for subcoating.
Claim 14
Dependent Claim
22 words
The method as claimed in claim 8 wherein the coating composition consists of a sugar syrup and a dusting powder for subcoating.
Claim 15
Dependent Claim
33 words
The method as claimed in claim 8 wherein the concentration of the hydroxypropylcellulose in the sugar syrup is from 2 to 20% by weight based on the total solid in the sugar syrup.
Claim 16
Dependent Claim
24 words
The method as claimed in claim 8 wherein the content of the hydroxypropylcellulose in the dusting powder is from 2 to 30% by weight.
Claim 17
Dependent Claim
19 words
The method as claimed in claim 8 wherein the hydroxypropylcellulose is additionally contained in the coating composition for smoothing.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-11-26 | 1983-05-28 | 1983-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-11-26 | 1987-05-28 | 1987-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-11-26 | 1991-05-28 | 1991-11-27 | $7700.00 | Window Closed / Lapsed |