Patent US4418070A successfully refreshed from Google Patents.
US4418070A
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US
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Cardiotonic agents
Assignee: MEIJI SEIKA 4-16 KYOBASHI 2-CHOME CHUO-KU TOKYO-TO JAPAN KK
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Filing: 1982-02-04
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Granted: 1983-11-29
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Expires: 2002-02-04
Abstract
Abstract A 5-phenylthiazole derivative represented by the formula: ##STR1## wherein R represents a hydrogen atom, a lower alkyl group, a hydroxyl group, an amino group or a mercapto group, or a pharmaceutically acceptable salt thereof shows a cardiac effect and a low toxicity to a human or animal with little influence on atrium rhythms.
Inventors
- 👤 Tsuneo Okonogi
- 👤 Shunzo Fukatsu
- 👤 Mitsugu Hachisu
- 👤 Hiroko Kawashima
- 👤 Keiko Shitoh
- 👤 Yasuharu Sekizawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:57
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/425; A61P; A61P9/00; A61P9/04; C; C07; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/34
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
59 words
A method for treating cardiac failure conditions, comprising: administering to a human or animal in need of such treatment a safe and effective amount of a 5-phenylthiazole derivative represented by the formula: ##STR11## wherein R represents a hydrogen atom, a lower alkyl group, a hydroxyl group, an amino group, or a mercapto group, or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
59 words
A method for treating cardiac failure conditions, comprising: administering to a human or animal in need of such treatment a safe and effective amount of a 5-phenylthiazole derivative represented by the formula: ##STR11## wherein R represents a hydrogen atom, a lower alkyl group, a hydroxyl group, an amino group, or a mercapto group, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
19 words
The method of claim 1, wherein said amount is from about 5 mg to about 0.5 g per day.
Claim 4
Dependent Claim
16 words
The method of claim 1, wherein said derivative is 2-amino-5-phenylthiazole or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
39 words
The method of claim 1, wherein the pharmaceutically acceptable salt is an acid addition salt of the 5-phenylthiazole derivative with an acid selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, succinic acid, and malic acid.
Claim 6
Dependent Claim
10 words
The method of claim 1, wherein said derivative is 2-hydroxy-5-phenylthiazole.
Claim 7
Dependent Claim
22 words
The method of claim 1, wherein said derivative is administered in a pharmaceutical composition comprising said derivative and a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
12 words
The method of claim 1, wherein said composition is in tablet form.
Claim 9
Dependent Claim
12 words
The method of claim 1, wherein said composition is in liquid form.
Claim 10
Dependent Claim
11 words
The method of claim 1, wherein said derivative is administered orally.
Claim 11
Dependent Claim
11 words
The method of claim 1, wherein said derivative is administered intraveneously.
Claim 12
Dependent Claim
1 words
2-Hydroxy-5-phenylthiazole.
Claim 13
Dependent Claim
1 words
2-Hydroxy-5-phenylthiazole.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-28 | 1987-05-30 | 1987-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-28 | 1991-05-30 | 1991-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-28 | 1995-05-30 | 1995-11-29 | $7700.00 | Window Closed / Lapsed |