Patent US4416866A successfully refreshed from Google Patents.
US4416866A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diagnosis and treatment of fluke infections with monoclonal antibodies
Assignee: Johns Hopkins University
•
Filing: 1981-08-28
•
Granted: 1983-11-22
•
Expires: 2001-08-28
Abstract
Abstract Antibodies and antigens are disclosed which provide a method of detecting and a method of combating flukes. Fluke infections are screened by determining presence of fluke antigens defined by antibodies produced by hybridomas ATCC HB-8086 and HB-8087. Chronic and acute fluke infections are distinguished by determining presence of fluke spine protein. Fluke infections are combated by injecting warm-blooded animals with antibodies produced by hybridomas ATCC HB-8086, HB-8087 and HB-8088, or with proteins defined by those antibodies.
Inventors
- 👤 Mette Strand
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:19
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/20; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
53 words
A screening method for the determination of a fluke infection of a warm-blooded animal which comprises testing a body component selected from the group consisting of serum, urine, milk and feces for the presence of glycoprotein molecules bound by antibodies produced by fused cell hybrid ATCC HB-8087 or fused cell hybrid ATCC HB-8086.
Claim 2
Dependent Claim
53 words
A screening method for the determination of a fluke infection of a warm-blooded animal which comprises testing a body component selected from the group consisting of serum, urine, milk and feces for the presence of glycoprotein molecules bound by antibodies produced by fused cell hybrid ATCC HB-8087 or fused cell hybrid ATCC HB-8086.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein the body component is urine.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein the body component is feces.
Claim 5
Dependent Claim
26 words
The method of claim 1 wherein said glycoprotein molecules are identified by an antibody assay selected from the group consisting of immunofluorescence, radioimmunoassay, and enzyme assay.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein said warm-blooded animal is a human.
Claim 7
Dependent Claim
47 words
A screening method for the determination of a fluke infection in a warm-blooded animal which comprises testing body serum for the presence of antibodies which bind glycoprotein molecules that are bound by the antibodies produced by fused cell hybrid ATCC HB-8087 or fused cell hybrid ATCC HB-8086.
Claim 8
Dependent Claim
47 words
A screening method for the determination of a fluke infection in a warm-blooded animal which comprises testing body serum for the presence of antibodies which bind glycoprotein molecules that are bound by the antibodies produced by fused cell hybrid ATCC HB-8087 or fused cell hybrid ATCC HB-8086.
Claim 9
Dependent Claim
10 words
The method of claim 6 wherein a human is tested.
Claim 10
Independent Claim
33 words
A method of combating fluke infection which comprises injecting a warm-blooded animal with a mixture of antibodies corresponding to the antibodies produced by fused cell hybrids ATCC HB-8086, ATCC HB-8087 and ATCC HB-8088.
Claim 11
Independent Claim
33 words
A method of combating fluke infection which comprises injecting a warm-blooded animal with a mixture of antibodies corresponding to the antibodies produced by fused cell hybrids ATCC HB-8086, ATCC HB-8087 and ATCC HB-8088.
Claim 12
Independent Claim
34 words
A method of combating fluke infection which comprises injecting a warm-blooded animal with a mixture of purified protein molecules bound by antibodies produced by fused cell hybrids ATCC HB-8086, ATCC HB-8087 and ATCC HB-8088.
Claim 13
Independent Claim
34 words
A method of combating fluke infection which comprises injecting a warm-blooded animal with a mixture of purified protein molecules bound by antibodies produced by fused cell hybrids ATCC HB-8086, ATCC HB-8087 and ATCC HB-8088.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-21 | 1987-05-23 | 1987-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-21 | 1991-05-23 | 1991-11-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-21 | 1995-05-23 | 1995-11-22 | $7700.00 | Window Closed / Lapsed |