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US4415555A
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Composition and method for treating iron deficiency syndrome
Assignee: Kyowa Chemical Industry Co Ltd
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Filing: 1982-03-17
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Granted: 1983-11-15
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Expires: 2002-03-17
Abstract
Abstract A composition for treating an iron deficiency disease, composed of (1) an amount, effective for treating said disease, of a compound having a hydrotalcite-like crystal structure and represented by the following formula (Fe2+,Mg2+)x(Al3+,Fe3+)2(OH)2x+6-nz(An-)z.mH2O wherein An- represents an anion having a valence of n, Mg2+ is within the range of O</=Mg2+<x, Fe3+ is within the range of O</=Fe3+ 2, x is a number represented by 1</=x<20, z is a number represented by 0<z<3, and m is a number represented by O</=m<8, and (2) a pharmaceutically acceptable diluent or carrier, and a method for treating an iron deficiency disease, which comprises orally administering an amount, effective for treating said disease, of the compound represented by the aforesaid formula.
Inventors
- 👤 Hitoshi Anabuki
- 👤 Shigeo Miyata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 16:10
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/28; A61K31/295; A61K33/00; A61K33/24; A61K33/26; A61K35/00; A61K35/02; A61P; A61P7/00; A61P7/06
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
109 words
A composition for increasing the iron level in hemoglobin and serum in a subject in need thereof comprising, (1) an amount, effective for increasing said iron level, of a compound having a hydrotalcite-like crystal structure and represented by the following formula (1) (Fe.sup.2+,Mg.sup.2+).sub.x (Al.sup.3+,Fe.sup.3+).sub.2 (OH).sub.2x+6-nz (A.sup.n-).sub.z.mH.sub.2 O (1) wherein A n- represents an anion having a valence of n, Mg 2+ is within the range of O≦Mg 2+ <x, Fe 3+ is within the range of O≦Fe 3+ <2, x is a number represented by 1≦x<20, z is a number represented by O<z<3, and m is a number represented by O≦m<8, and (2) a pharmaceutically acceptable diluent or carrier.
Claim 2
Dependent Claim
109 words
A composition for increasing the iron level in hemoglobin and serum in a subject in need thereof comprising, (1) an amount, effective for increasing said iron level, of a compound having a hydrotalcite-like crystal structure and represented by the following formula (1) (Fe.sup.2+,Mg.sup.2+).sub.x (Al.sup.3+,Fe.sup.3+).sub.2 (OH).sub.2x+6-nz (A.sup.n-).sub.z.mH.sub.2 O (1) wherein A n- represents an anion having a valence of n, Mg 2+ is within the range of O≦Mg 2+ <x, Fe 3+ is within the range of O≦Fe 3+ <2, x is a number represented by 1≦x<20, z is a number represented by O<z<3, and m is a number represented by O≦m<8, and (2) a pharmaceutically acceptable diluent or carrier.
Claim 3
Dependent Claim
31 words
The composition of claim 1 wherein said compound (1) is represented by the following formula (Fe.sup.2+).sub.x (Al.sup.3+).sub.2 (OH).sub.2x+6-2z (CO.sub.3.sup.2-).sub.z.mH.sub.2 O wherein x, z and m are as defined in claim 1.
Claim 4
Dependent Claim
15 words
The composition of claim 1 or 2 wherein x is a number represented by 2.5≦x<8.
Claim 5
Dependent Claim
67 words
The composition of claim 1 wherein A n- is an anion selected from the group consisting of CO 3 2- , SO 4 2- , OH -1 , (CHOHCOO) 2 2- , (CHOH) 4 CH 2 OHCOO 1- , C 2 H 2 (COO) 2 2- , (CH 2 COO) 2 2- , C 5 H 9 O 5 COO 1- and CH 3 CHOHCOO 1- .
Claim 6
Dependent Claim
26 words
The composition of claim 1 wherein the amount of the compound (1) is about 30 to about 95% based on the total weight of the composition.
Claim 7
Dependent Claim
67 words
The composition of claim 1 wherein said compound (1) is obtained by reacting an aqueous solution of a water-soluble divalent iron salt or an aqueous solution of a water-soluble divalent iron salt and a water-soluble magnesium salt with an aqueous solution of a water-soluble aluminum compound or an aqueous solution of a water-soluble aluminum compound and a water-soluble trivalent iron salt in the presence of an alkali.
Claim 8
Independent Claim
101 words
A method for, increasing the iron level of hemoglobin and serum in a subject in need thereof, which comprises orally administering an amount, effective for increasing said iron level, of a compound having a hydrotalcite-like crystal structure and represented by the following formula (Fe.sup.2+,Mg.sup.2+).sub.x (Al.sup.3+,Fe.sup.3+).sub.2 (OH).sub.2x+6-nz (A.sup.n-).sub.z.mH.sub.2 O wherein A n- represents an anion having a valence of n, Mg 2+ is within the range of O≦Mg 2+ <z, Fe 3+ is within the range of O≦Fe 3+ -2, x is a number represented by 1≦x<20, z is a number represented by O<z<3, and m is a number represented by O≦m-8.
Claim 9
Independent Claim
101 words
A method for, increasing the iron level of hemoglobin and serum in a subject in need thereof, which comprises orally administering an amount, effective for increasing said iron level, of a compound having a hydrotalcite-like crystal structure and represented by the following formula (Fe.sup.2+,Mg.sup.2+).sub.x (Al.sup.3+,Fe.sup.3+).sub.2 (OH).sub.2x+6-nz (A.sup.n-).sub.z.mH.sub.2 O wherein A n- represents an anion having a valence of n, Mg 2+ is within the range of O≦Mg 2+ <z, Fe 3+ is within the range of O≦Fe 3+ -2, x is a number represented by 1≦x<20, z is a number represented by O<z<3, and m is a number represented by O≦m-8.
Claim 10
Dependent Claim
30 words
The method of claim 7 wherein said compound is represented by the following formula (Fe.sup.2+).sub.x (Al.sup.3+).sub.2 (OH).sub.2x+6-2z (CO.sub.3.sup.2-).sub.z.mH.sub.2 O wherein x, z and m are as defined in claim 7.
Claim 11
Dependent Claim
25 words
The method of claim 7 or 8 wherein the dosage of the compound is about 50 mg to about 2,000 mg per day per adult.
Claim 12
Dependent Claim
13 words
The method of claim 9 for treating a patient suffering from anemic symptoms.
Claim 13
Dependent Claim
18 words
The method of claim 10 for increasing the hemoglobin level of a patient suffering from iron deficiency anemia.
Claim 14
Dependent Claim
16 words
The method of claim 9 wherein the compound is administered to a patient suffering from hypoferremia.
Claim 15
Dependent Claim
21 words
The method of claim 9 wherein x is a number represented by 2.5≦x<8 and z is a number represented by 1≦z≦2.
Claim 16
Dependent Claim
13 words
The composition of claim 3 wherein z is a number represented by 1≦z≦1.
Claim 17
Dependent Claim
24 words
The composition of claim 1 wherein the compound (1) has the formula Fe 4 2+ Al 2 (OH) 12 CO 3 .3H 2 O.
Claim 18
Dependent Claim
27 words
The composition of claim 1 wherein the compound (1) has the formula Fe 3 2+ Al 2 (OH) 10 .4 (CH 2 COO) 1 .6.1.8H 2 O.
Claim 19
Dependent Claim
33 words
The composition of claim 1 wherein the compound (1) has the formula Fe 5 .1 2+ Al 1 .4 Fe 0 .6 3+ (OH) 14 .0 (SO) 4 ) 1 .1.3.2H 2 O.
Claim 20
Dependent Claim
24 words
The composition of claim 1 wherein the compound (1) has the formula Fe 5 2+ MgAl 2 (OH) 16 CO 3 .4H 2 O.
References Cited (Backward Citations)
US3650704A
Cited
US3829561A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-14 | 1987-05-16 | 1987-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-14 | 1991-05-16 | 1991-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-14 | 1995-05-16 | 1995-11-15 | $7700.00 | Window Closed / Lapsed |