Patent US4414145A successfully refreshed from Google Patents.
US4414145A
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Preparation and use of a 195M-AU-containing liquid
Assignee: MAALLINCKRODT DIAGNOSTICA (HOLLAND) BV WESTERDUINWEG 3 1755 LE PETTEN NETHERLANDS
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Filing: 1980-04-16
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Granted: 1983-11-08
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Expires: 2000-04-16
Abstract
Abstract A method for preparing a 195mAu-containing liquid is provided. In the method, 195mHg is adsorbed on an adsorption agent and then the daughter radioisotope 195mAu is eluted from the adsorption agent with an eluant containing a gold-complexing agent. The adsorption agent comprises a mercury ion-binding material having a substantially stronger adsorption affinity for mercury ions than for gold ions. Also disclosed are a radioisotope generator capable of producing a 195mAu-containing liquid and a process for conducting a radiodiagnostic examination on a warm-blooded animal using a 195mAu-containing liquid.
Inventors
- 👤 Karel J. Panek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 05:27
CPC Classifications
G; G21; G21G; G21G1/00; G21G1/0005; A; A61; A61B; A61B5/00; A61B5/02; A61B5/026; A61B5/0275; A61B5/02755; G21G1/04; G21G1/001; G21G2001/0094
Claims Analysis
Total Claims: 76
Claim 1
Independent Claim
107 words
A method of preparing a non-toxic, pharmaceutically acceptable, 195m Au-containing liquid capable of direct administration in a living being and substantially devoid of 195m Hg ions, wherein the 195m Au is a daughter radioisotope of the 195m Hg ion, comprising: (a) adsorbing 195m Hg on a chemically and radiolytically stable adsorption agent comprising a mercury ion-binding material having a significantly higher affinity for mercury ions than for gold ions, and (b) eluting the daughter 195m Au radioisotope with an eluant which selectively converts 195m Au ions to an elutable form in the presence of the adsorbed parent 195m Hg radioisotope, and which is non-toxic and pharmaceutically acceptable.
Claim 2
Independent Claim
107 words
A method of preparing a non-toxic, pharmaceutically acceptable, 195m Au-containing liquid capable of direct administration in a living being and substantially devoid of 195m Hg ions, wherein the 195m Au is a daughter radioisotope of the 195m Hg ion, comprising: (a) adsorbing 195m Hg on a chemically and radiolytically stable adsorption agent comprising a mercury ion-binding material having a significantly higher affinity for mercury ions than for gold ions, and (b) eluting the daughter 195m Au radioisotope with an eluant which selectively converts 195m Au ions to an elutable form in the presence of the adsorbed parent 195m Hg radioisotope, and which is non-toxic and pharmaceutically acceptable.
Claim 3
Dependent Claim
44 words
A method according to claim 1 wherein said adsorption agent is selected from the group consisting of activated carbon, silver, hydrated manganese dioxide, and metal sulfides and said eluant is a nontoxic, pharmaceutically acceptable solution which selectively converts 195m Au to an elutable form.
Claim 4
Dependent Claim
17 words
A method as set forth in claim 2 wherein the mercury ion-binding material is a metal sulphide.
Claim 5
Dependent Claim
30 words
A method as set forth in claim 3 wherein the mercury ion-binding material is a metal sulphide selected from the group consisting of zinc sulphide, zirconium sulphide and silver sulphide.
Claim 6
Independent Claim
39 words
A method as set forth in claims 1, 2, 3, or 4 wherein the adsorption agent contains a substrate material selected from the group consisting of silica gel, aluminum oxide, natural or synthetic aluminum silicate, activated carbon, and glass.
Claim 7
Independent Claim
22 words
A method as set forth in claims 1, 2, 3 or 4 wherein the adsorption agent contains a silica gel substrate material.
Claim 8
Dependent Claim
23 words
A method as set forth in claim 1 wherein the adsorption agent contains a substrate material selected from polymers and copolymers of styrene.
Claim 9
Dependent Claim
32 words
A method as set forth in claim 1 wherein the adsorption agent comprises particulate substrate material and the mercury ion-binding material is on the surface of the particles of the substrate material.
Claim 10
Dependent Claim
27 words
A method as set forth in claim 8 wherein the mercury ion-binding material is selected from the group consisting of hydrated manganese dioxide, metal sulphides and silver.
Claim 11
Dependent Claim
30 words
A method as set forth in claim 9 wherein the mercury ion-binding material is a metal sulphide selected from the group consisting of zinc sulphide, zirconium sulphide and silver sulphide.
Claim 12
Dependent Claim
31 words
A method as set forth in claim 10, the substrate material is silica gel and the mercury ion-binding material is selected from the group consisting of zinc sulphide and silver sulphide.
Claim 13
Dependent Claim
27 words
A method as set forth in claim 11 wherein the adsorption agent comprises silical gel containing about 0.1-20 mg of zinc sulphide per g of silica gel.
Claim 14
Dependent Claim
29 words
A method as set forth in claim 12 wherein the adsorption agent comprises silica gel containing about 0.8 to 10 mg of zinc sulphide per g of silica gel.
Claim 15
Dependent Claim
32 words
A method as set forth in claim 9 wherein the substrate material is silica gel and the mercury ion-binding material is selected from the group consisting of hydrated manganese dioxide and silver.
Claim 16
Dependent Claim
25 words
A method as set forth in claim 8 wherein the substrate material is selected from the group consisting of silica gel, silicate material and glass.
Claim 17
Dependent Claim
25 words
A method as set forth in claim 15 wherein the mercury ion-binding material is chemically bonded to the surfaces of the particles of substrate material.
Claim 18
Dependent Claim
33 words
A method as set forth in claim 16 wherein the mercury ion-binding material has a terminal functional group selected from the group consisting of thiol-, amino, hydroxy-, carbamate, dithiocarbamate-, xanthate-, and carboxy-functional groups.
Claim 19
Dependent Claim
25 words
A method as set forth in claim 8 wherein the mercury ion-binding material is chemically bonded to the surfaces of the particles of substrate material.
Claim 20
Dependent Claim
33 words
A method as set forth in claim 18 wherein the mercury ion-binding material has a terminal functional group selected from the group consisting of thiol-, amino-, hydroxy-, carbamate-, dithiocarbamate, xanthate-, and carboxy-functional groups.
Claim 21
Independent Claim
51 words
A method as set forth in claims 1, 2, 8, 11, 15, 18, 16, 19 or 17, wherein the eluant used for the elution of the daughter isotope 195m Au is a pharmaceutically-acceptable solution of a gold ion-complexing agent selected from the group consisting of amines, amino acids and sulphur-containing compounds.
Claim 22
Dependent Claim
30 words
A method as set forth in claim 20 wherein the gold ion-complexing agent is selected from the group consisting of thiosulphate, tris(hydroxymethyl)aminomethane, hippurate, glutathione, mercaptopropionyl glycine, thiomalate, thiosalicylate and rhodanide.
Claim 23
Dependent Claim
26 words
A method as set forth in claim 21, the eluant is a solution of a gold ion-complexing agent which contains a minor amount of gold carrier.
Claim 24
Dependent Claim
22 words
A method as set forth in claim 22 wherein the eluant is a gold ion-complexing agent which contains a dissolved radical scavenger.
Claim 25
Dependent Claim
34 words
A method as set forth in claim 23 wherein the radical scavenger is selected from the group consisting of alkali metal nitrates, alkaline earth metal nitrates, alkali metal nitrites and alkaline earth metal nitrites.
Claim 26
Dependent Claim
27 words
A method as set forth in claim 20 wherein the eluant is a solution of a gold ion-complexing agent which contains a small amount of gold carrier.
Claim 27
Dependent Claim
25 words
A method as set forth in claim 20 wherein the eluant is a solution of a gold ion-complexing agent which contains a dissolved radical scavenger.
Claim 28
Dependent Claim
34 words
A method as set forth in claim 26 wherein the radical scavenger is selected from the group consisting of alkali metal nitrates, alkaline earth metal nitrates, alkali metal nitrites and alkaline earth metal nitrites.
Claim 29
Dependent Claim
52 words
A method as set forth in claim 18 or 16 wherein the adsorption agent for the parent isotope includes particulate silica gel, the particles of which have at their surface chemically bound groups with thiol functions in the terminal position, and the eluant for the daughter radioisotope is a solution of thiosulphate.
Claim 30
Dependent Claim
50 words
A method as set forth in claim 18 or 16 the adsorption agent for the parent isotope includes particulate silica gel, the particles of which have at their surface chemically bound groups having amino functions in the terminal position, and the eluant for the daughter radioisotope is solution of tris(hydroxymethyl)aminomethane.
Claim 31
Dependent Claim
27 words
A method as set forth in claim 18 or 16 wherein the mercury ion-binding material is selected from the group consisting of macrocyclic, heteromacrocyclic and polycyclic ligands.
Claim 32
Dependent Claim
35 words
A method as set forth in claim 8, 18 or 16 wherein the mercury ion-binding material has been subject to a deactivation treatment so that the material has a reduced adsorption affinity for gold ions.
Claim 33
Dependent Claim
22 words
A method as set forth in claim 31 wherein deactivation treatment comprises a chemical reaction selected from substitution, cleavage, condensation and oxidation.
Claim 34
Dependent Claim
29 words
A method as set forth in claim 32 wherein the deactivation treatment is an oxidation chemical reaction employing an oxidation agent selected from iodine, bromine, chromic acid and permanganate.
Claim 35
Dependent Claim
31 words
A method as set forth in claim 1 wherein the eluant used for the elution of the daughter isotope 195m Au is a pharmaceutically acceptable solution of a gold ion-complexing agent.
Claim 36
Dependent Claim
22 words
A method as set forth in claim 34 wherein the solution of gold ion-complexing agent contains a minor amount of gold carrier.
Claim 37
Independent Claim
23 words
A method as set forth in claims 34, 2 or 19 wherein the solution of gold ion-complexing agent contains a dissolved radical scavenger.
Claim 38
Dependent Claim
34 words
A method as set forth in claim 36 wherein the radical scavenger is selected from the group consisting of alkali metal nitrates, alkaline earth metal nitrates, alkali metal nitrites and alkaline earth metal nitrites.
Claim 39
Dependent Claim
28 words
A method as set forth in claim 37 wherein the radical scavenger is contained in a quantity of about 0.0001-5 wt/vol. % calculated on the quantity of eluant.
Claim 40
Dependent Claim
28 words
A method as set forth in claim 38 wherein the radical scanvenger is contained in a quantity of about 0.5-2 wt/vol. % calculated on the quantity of eluant.
Claim 41
Dependent Claim
44 words
A method as set forth in claim 8 wherein the adsorption agent for the parent isotope 195m Hg includes particulate silica gel, the particles of which have zinc sulphide at the surface, and the eluant for the daughter radiosotope is a solution of thiosulphate.
Claim 42
Dependent Claim
54 words
The method as set forth in claim 8 wherein the adsorption agent for the patent isotope includes particulate silica gel, the particles of which have hydrated manganese dioxide at the surface and the eluant for the daughter radioisotope is a solution of a gold-complexing agent selected from the group consisting of tris(hydroxymethyl)aminomethane and hippurate.
Claim 43
Dependent Claim
53 words
A method as set forth in claim 8 wherein the adsorption agent for the present isotope includes particulate silica gel, the particles of which have silver sulphide at the surface, and the eluant for the daughter radioisotope is a solution of a gold-complexing agent selected from the group consisting of glutathione and thiomalate.
Claim 44
Dependent Claim
53 words
A method as set forth in claim 8, the adsorption agent the parent isotope includes particulate silica gel, the particles of which have silver at the surface and the eluant for the daughter radioisotope is a solution of a gold complexing agent selected from the group consisting of glutathione, mercaptopropionyl glycine, and thiomalate.
Claim 45
Dependent Claim
38 words
A method as set forth in claim 1 wherein 195m Hg is adsorbed on the adsorption agent by contacting the adsorption agent with a solution of 195m Hg ions having a pH of about 1 to about 10.
Claim 46
Dependent Claim
20 words
A method as set forth in claim 44 wherein the solution has a pH of about 5 to about 6.
Claim 47
Dependent Claim
110 words
A radioisotope generator system for generating a non-toxic, pharmaceutically acceptable 195m Au-containing liquid capable of direct administration in a living being and substantially devoid of 195m Hg ions, wherein the 195m Au is a daughter radioisotope of the 195m Hg ion, comprising: (a) a chemically and radiolytically stable mercury ion-binding adsorption agent having a significantly higher affinity for mercury ions than for gold ions; (b) 195m Hg adsorbed on said adsorption agent as a parent radioisotope; and (c) an eluant for eluting said daughter radioisotope which selectively converts 195m Au ions to an elutable form in the presence of the adsorbed parent 195m Hg radioisotope, is non-toxic and pharmaceutically acceptable.
Claim 48
Dependent Claim
110 words
A radioisotope generator system for generating a non-toxic, pharmaceutically acceptable 195m Au-containing liquid capable of direct administration in a living being and substantially devoid of 195m Hg ions, wherein the 195m Au is a daughter radioisotope of the 195m Hg ion, comprising: (a) a chemically and radiolytically stable mercury ion-binding adsorption agent having a significantly higher affinity for mercury ions than for gold ions; (b) 195m Hg adsorbed on said adsorption agent as a parent radioisotope; and (c) an eluant for eluting said daughter radioisotope which selectively converts 195m Au ions to an elutable form in the presence of the adsorbed parent 195m Hg radioisotope, is non-toxic and pharmaceutically acceptable.
Claim 49
Dependent Claim
46 words
A radioisotope generator system according to claim 46 wherein said adsorption agent is selected from the group consisting of activated carbon, silver, hydrated manganese dioxide, and metal sulfides, and said eluant is a nontoxic, pharmaceutically acceptable solution which selectively converts 195m Au to an elutable form.
Claim 50
Dependent Claim
25 words
A radioisotope generator as set forth in claim 47, wherein the column contains sufficient adsorbed 195m Hg to have a radioactivity of about 1-300 mCi.
Claim 51
Dependent Claim
25 words
A radioisotope generator as set forth in claim 48 where the column contains sufficient adsorbed 195m Hg to have a radioactivity of about 20-160 mCi.
Claim 52
Dependent Claim
24 words
A radioisotope generator as set forth in claim 46 or 47 wherein the generator contains means for directly connecting the generator to a patient.
Claim 53
Dependent Claim
18 words
A radioisotope generator as set forth in claim 47 wherein the mercury ion-binding material is a metal sulphide.
Claim 54
Dependent Claim
31 words
A radioisotope generator as set forth in claim 51 wherein the mercury ion-binding material is a metal sulphide selected from the group consisting of zinc sulphide, zirconium sulphide and silver sulphide.
Claim 55
Dependent Claim
103 words
A radioisotope generator as set forth in claim 46, wherein the generator comprises a reservoir adapted to contain eluant and in communication with the column, means for pumping eluant from the reservoir into the column and forcing the resulting eluant from the column to the body of a patient, means for adding a formulating liquid to the eluate, and a tube connected at one end to the means for adding a formulating liquid and having, at the other end, a member capable of being connected to an auxiliary means for allowing liquid to flow into blood vessels or body cavities of a patient.
Claim 56
Dependent Claim
39 words
A radioisotope generator as claimed in claims 46, 53, 47, 51 or 52 wherein the adsorption agent comprises a substrate selected from the group consisting of silica gel, aluminum oxide, natural or synthetic aluminum silicate, activated carbon and glass.
Claim 57
Dependent Claim
24 words
A radioisotope generator as set forth in claims 46, 53, 47, 51 or 52 wherein the adsorption agent contains a silica gel substrate material.
Claim 58
Dependent Claim
24 words
A radioisotope generator as set forth in claim 46, wherein the adsorption agent contains a substrate material selected from polymers and copolymers of styrene.
Claim 59
Dependent Claim
34 words
A radioisotope generator as set forth in claim 46 wherein the adsorption agent contains a particulate substrate material and the mercury ion-binding material is on the surface of the particles of the substrate material.
Claim 60
Dependent Claim
28 words
A radioisotope generator as set forth in claim 57 wherein the mercury ion-binding material is selected from the group consisting of hydrated manganese dioxide, metal sulphides and silver.
Claim 61
Dependent Claim
31 words
A radioisotope generator as set forth in claim 58 wherein the mercury ion-binding material is a metal sulphide selected from the group consisting of zinc sulphide, zirconium sulphide and silver sulphide.
Claim 62
Dependent Claim
33 words
A radioisotope generator as set forth in claim 59 wherein the substrate material is silica gel and the mercury ion-binding material is selected from the group consisting of zinc sulphide and silver sulphide.
Claim 63
Dependent Claim
28 words
A radioisotope generator as set forth in claim 60 wherein the adsorption agent comprises silica gel containing about 0.1-20 mg of zinc sulphide per g of silica gel.
Claim 64
Dependent Claim
30 words
A radioisotope generator as set forth in claim 61 wherein the adsorption agent comprises silica gel containing about 0.8 to 10 mg of zinc sulphide per g of silica gel.
Claim 65
Dependent Claim
33 words
A radioisotope generator as set forth in claim 58 wherein the substrate material is silica gel and the mercury ion-binding material is selected from the group consisting of hydrated manganese dioxide and silver.
Claim 66
Dependent Claim
26 words
A radioisotope generator as set forth in claim 57 wherein the substrate material is selected from the group consisting of silica gel, silicate material and glass.
Claim 67
Dependent Claim
29 words
A radioisotope generator as is set forth in claims 57 or 64 wherein the mercury ion-binding material is chemically bonded to the surfaces of the particles of substrate material.
Claim 68
Dependent Claim
36 words
A radioisotope generator as set forth in claim 65 wherein the mercury-ion binding material contains a function in the terminal position selected from the group consisting of thiol-, amino-, hydroxy-, carbamate-, dithiocarbamate-, xanthate-, and carboxy functions.
Claim 69
Dependent Claim
39 words
A radioisotope generator as set forth in claim 65 wherein the adsorption agent for the parent isotope includes particulate silica gel, the particles of which have at their surface chemically bound groups with thiol functions in the terminal position.
Claim 70
Dependent Claim
38 words
A radioisotope generator as set forth in claim 65 wherein the adsorption agent for the parent isotope includes particulate silica gel, the particles of which have at their surface chemically-bound groups having amino functions in the terminal position.
Claim 71
Dependent Claim
29 words
A radioisotope generator as set forth in claim 65 wherein the adsorption agent contains a mercury ion-binding material selected from the group consisting of macrocyclic, heteromacrocyclic and polycyclic ligands.
Claim 72
Dependent Claim
32 words
The radioisotope generator as set forth in claim 57 wherein the adsorption agent for the parent isotope includes particulate silica gel, the particles of which have hydrated manganese dioxide at the surface.
Claim 73
Dependent Claim
31 words
A radioisotope generator as set forth in claim 57 wherein the adsorption agent for the parent isotope includes particulate silica gel, the particles of which have silver sulphide at the surface.
Claim 74
Dependent Claim
30 words
A radioisotope generator as set forth in claim 57 wherein the adsorption agent for the parent isotope includes particulate silica gel, the particles for which have silver at the surface.
Claim 75
Dependent Claim
53 words
An adsorption agent for use in preparing a 195m Au-containing liquid substantially devoid of 195M Hg ions, wherein the 195m Au is a daugher radioisotope comprising a chemically and radiolytically stable mercury ion-binding material having a substantially stronger adsorption affinity for mercury ions than for gold ions and a silica gel substrate material.
Claim 76
Dependent Claim
53 words
An adsorption agent for use in preparing a 195m Au-containing liquid substantially devoid of 195M Hg ions, wherein the 195m Au is a daugher radioisotope comprising a chemically and radiolytically stable mercury ion-binding material having a substantially stronger adsorption affinity for mercury ions than for gold ions and a silica gel substrate material.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-07 | 1987-05-09 | 1987-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-07 | 1991-05-09 | 1991-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-07 | 1995-05-09 | 1995-11-08 | $7700.00 | Window Closed / Lapsed |