Patent US4414079A successfully refreshed from Google Patents.
US4414079A
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Process for the preparation of a 4-butanolide compound
Assignee: Asahi Kasei Corp
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Filing: 1982-07-15
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Granted: 1983-11-08
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Expires: 2002-07-15
Abstract
Abstract The electrolytic reduction of a mixture of an acrylic ester and an aldehyde in the form of an aqueous emulsion in the presence of at least one phase-transfer catalyst using a lead or lead alloy cathode has been found to be very effective for preparing a 4-butanolide compound simply and safely in high yield with a high current efficiency.
Inventors
- 👤 Kazunori Yamataka
- 👤 Toshiro Isoya
- 👤 Nobuya Kitaguchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 10:56
CPC Classifications
C; C07; C07D; C07D315/00; C25; C25B; C25B3/00; C25B3/01; C25B3/05; C25B3/07; C25B3/20; C25B3/25
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
255 words
A process for the preparation of a 4-butanolide compound which comprises subjecting a mixture of an acrylic ester and an aldehyde selected from the group consisting of aliphatic aldehydes having 1 to 13 carbon atoms, aromatic aldehydes and aralkyl aldehydes to electrolytic reduction, said mixture of the acrylic ester and the aldehyde being in the form of an aqueous emulsion comprising a water phase and an organic phase, in the presence of at least one phase-transfer catalyst selected from the group consisting of quaternary ammonium salts represented by the general formula: ##STR3## wherein X stands for an acid radical, n stands for an integer corresponding to the valence of X, and R 1 , R 2 , R 3 and R 4 each independently stand for an alkyl group or an aralkyl group, provided that, when said aldehyde is an aliphatic aldehyde having 5 to 13 carbon atoms, an aromatic aldehyde or an aralkyl aldehyde, the total number of carbon atoms in R 1 , R 2 , R 3 and R 4 of the quaternary ammonium ion moiety is 12 to 30, said total number of carbon atoms is R 1 , R 2 , R 3 and R 4 being calculated by the equation n×(carbon number in R 1 +carbon number in R 2 +carbon number in R 3 +carbon number in R 4 )/n, and quaternary phosphonium salts in an electrolytic cell provided with at least one pair of anode and cathode, said cathode being made of lead or a lead alloy.
Claim 2
Dependent Claim
255 words
A process for the preparation of a 4-butanolide compound which comprises subjecting a mixture of an acrylic ester and an aldehyde selected from the group consisting of aliphatic aldehydes having 1 to 13 carbon atoms, aromatic aldehydes and aralkyl aldehydes to electrolytic reduction, said mixture of the acrylic ester and the aldehyde being in the form of an aqueous emulsion comprising a water phase and an organic phase, in the presence of at least one phase-transfer catalyst selected from the group consisting of quaternary ammonium salts represented by the general formula: ##STR3## wherein X stands for an acid radical, n stands for an integer corresponding to the valence of X, and R 1 , R 2 , R 3 and R 4 each independently stand for an alkyl group or an aralkyl group, provided that, when said aldehyde is an aliphatic aldehyde having 5 to 13 carbon atoms, an aromatic aldehyde or an aralkyl aldehyde, the total number of carbon atoms in R 1 , R 2 , R 3 and R 4 of the quaternary ammonium ion moiety is 12 to 30, said total number of carbon atoms is R 1 , R 2 , R 3 and R 4 being calculated by the equation n×(carbon number in R 1 +carbon number in R 2 +carbon number in R 3 +carbon number in R 4 )/n, and quaternary phosphonium salts in an electrolytic cell provided with at least one pair of anode and cathode, said cathode being made of lead or a lead alloy.
Claim 3
Dependent Claim
18 words
A process according to claim 1, wherein said acrylic ester is a lower alkyl ester of acrylic acid.
Claim 4
Dependent Claim
17 words
A process according to claim 2, wherein said lower alkyl ester of acrylic acid is methyl acrylate.
Claim 5
Dependent Claim
33 words
A process according to claim 1, wherein said organic phase is present in said aqueous emulsion in a volume ratio of 0.05 to 0.5 relative to the total volume of said aqueous emulsion.
Claim 6
Dependent Claim
22 words
A process according to claim 1, wherein said electrolytic reduction is carried out in a two-compartment electrolytic cell partitioned by a diaphragm.
Claim 7
Dependent Claim
24 words
A process according to claim 1, wherein said aldehyde is employed in a molar ratio of 1 to 10 relative to said acrylic ester.
Claim 8
Dependent Claim
31 words
A process according to claim 1, wherein said electrolytic reduction is carried out in the presence of at least one inorganic electrolyte in addition to said at least one phase-transfer catalyst.
Claim 9
Dependent Claim
42 words
A process according to claim 7, wherein said inorganic electrolyte is at least one compound selected from the group consisting of sulfuric acid, phosphoric acid, an alkali metal sulfate, an alkali metal hydrogensulfate, a dialkali metal hydrogenphosphate and an alkali metal dihydrogenphosphate.
Claim 10
Dependent Claim
143 words
A process according to claim 1, wherein said aldehyde is an aliphatic aldehyde having up to 4 carbon atoms and said phase-transfer catalyst is a quaternary ammonium salt represented by the general formula: ##STR4## wherein X stands for an acid radical, n stands for an integer corresponding to the valence of X, and R 1 , R 2 , R 3 and R 4 each independently stand for an alkyl group or an aralkyl group, provided that the total number of carbon atoms in R 1 , R 2 , R 3 and R 4 is 4 to 20, said total number of carbon atoms in R 1 , R 2 , R 3 and R 4 being calculated by the equation n×(carbon number in R 1 +carbon number in R 2 +carbon number in R 3 +carbon number in R 4 )/n.
Claim 11
Dependent Claim
47 words
A process according to claim 9, wherein each of R 1 , R 2 , R 3 and R 4 is an alkyl group and the total number of carbon atoms in R 1 , R 2 , R 3 and R 4 is 4 to 16.
Claim 12
Dependent Claim
45 words
A process according to claim 10, wherein at least one of R 1 , R 2 , R 3 and R 4 is an alkyl group selected from the group consisting of a methyl group, an ethyl group, a propyl group and a butyl group.
Claim 13
Dependent Claim
150 words
A process according to claim 1, wherein said aldehyde is an aliphatic aldehyde having 5 to 13 carbon atoms, an aromatic aldehyde or an aralkyl aldehyde, and said phase-transfer catalyst is a quaternary ammonium salt represented by the general formula: ##STR5## wherein X stands for an acid radical, n stands for an integer corresponding to the valence of X, and R 1 , R 2 , R 3 and R 4 each independently stand for an alkyl group or an aralkyl group, provided that the total number of carbon atoms in R 1 , R 2 , R 3 and R 4 is 12 to 20, said total number of carbon atoms in R 1 , R 2 , R 3 and R 4 being calculated by the equation n×(carbon number in R 1 +carbon number in R 2 +carbon number in R 3 +carbon number in R 4 )/n.
Claim 14
Dependent Claim
42 words
A process according to claim 12, wherein R 1 , R 2 , R 3 and R 4 each independently represent an alkyl group and at least three of them each independently represent an alkyl group having at least three carbon atoms.
Claim 15
Dependent Claim
39 words
A process according to claim 13, wherein at least one of R 1 , R 2 , R 3 and R 4 is an alkyl group selected from the group consisting of a propyl group and a butyl group.
Claim 16
Dependent Claim
24 words
A process according to claim 14, wherein each of R 1 , R 2 , R 3 and R 4 is a butyl group.
Claim 17
Dependent Claim
154 words
A process according to claim 7, wherein said aldehyde is an aliphatic aldehyde having 5 to 13 carbon atoms, aromatic aldehyde or an aralkyl aldehyde, and said phase-transfer catalyst is a quaternary ammonium salt represented by the general formula: ##STR6## wherein X stands for an acid radical, n stands for an integer corresponding to the valence of X, and R 1 , R 2 , R 3 and R 4 each independently stand for an alkyl group or an aralkyl group, provided that the total number of carbon atoms in R 1 , R 2 , R 3 and R 4 is 12 to 30, said total number of carbon atoms in R 1 , R 2 , R 3 and R 4 being calculated by the equation n×(carbon number in R 1 +carbon number in R 2 +carbon number in R 3 +carbon number in R 4 )/n, or a quaternary phosphonium salt.
Claim 18
Dependent Claim
39 words
A process according to claim 16, wherein said quaternary ammonium salt is employed in an amount of 0.1 to 50 mol % based on the amount of said acrylic ester or said aldehyde, whichever is less in amount employed.
Claim 19
Dependent Claim
39 words
A process according to claim 16, wherein said quaternary phosphonium salt is employed in an amount of 0.1 to 50 mol % based on the amount of said acrylic ester or said aldehyde, whichever is less in amount employed.
Claim 20
Dependent Claim
30 words
A process according to claim 9, 12 or 16, wherein said acid radical is a sulfate ion, sulfonate ion, phosphate ion, hydrogenphosphate ion, dihydrogenphosphate ion, hydrogensulfate ion or halide ion.
Claim 21
Dependent Claim
25 words
A process according to claim 17, wherein said acid radical is a sulfate ion, p-toluenesulfonate ion, phosphate ion, hydrogenphosphate ion, dihydrogenphosphate ion, or hydrogensulfate ion.
References Cited (Backward Citations)
US3630861A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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