Patent US1730704A successfully refreshed from Google Patents.
Patent US4412068A successfully refreshed from Google Patents.
US4412068A
Expired / Lapsed
US
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Novel compounds of the gentamicin class
Assignee: STWB Inc
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Filing: 1981-06-08
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Granted: 1983-10-25
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Expires: 2001-06-08
Abstract
Abstract 5-Deoxygentamicin C 2b and 6'-N-methyl-2-hydroxy- and 6'-N-methyl-5-deoxygentamicins C 2b are prepared, as the major fermentation products, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and either D-streptamine or 2,5-dideoxystreptamine with a mutant of Micromonospora purpurea and isolating the fermentation products from the nutrient medium. The fermentation products are acylated with an ester of an ω-[N-(benzyloxycarbonyl)amino]-α-hydroxy-lower-alkanoic acid after first blocking the primary amino group at the 2'-position with an amine-protecting group, followed by catalytic hydrogenolysis of the benzyloxycarbonyl group and removal of the amine-protecting group to prepare the 1-(ω-amino-α-hydroxy-lower-alkanoyl) derivatives.
Inventors
- 👤 David Rosi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:33
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; C07H15/222; C07H15/226; C07H15/234; C07H15/236; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P19/00; C12P19/44; C12P19/46; C12P19/48; C12P19/485; C12R; C12R2001/00; C12R2001/01; C12R2001/29; C12R2001/31; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/867; Y10S435/869
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
73 words
A member of the group consisting of (A) a compound having the formula: ##STR3## where R 1 is hydrogen or the group, H 2 N(CH 2 ) n CHOHCO--, where n is one of the integers 1 or 2; R 2 and R 5 are either both hydroxy or both hydrogen; and R 6 is hydrogen or methyl, R 2 being hydroxy only when R 6 is methyl; and (B) acid-addition salts thereof.
Claim 2
Dependent Claim
73 words
A member of the group consisting of (A) a compound having the formula: ##STR3## where R 1 is hydrogen or the group, H 2 N(CH 2 ) n CHOHCO--, where n is one of the integers 1 or 2; R 2 and R 5 are either both hydroxy or both hydrogen; and R 6 is hydrogen or methyl, R 2 being hydroxy only when R 6 is methyl; and (B) acid-addition salts thereof.
Claim 3
Dependent Claim
5 words
O-[3-Deoxy-4-C-methyl-3-methylamino-β-L-arabinopyranosyl-(1→6)]-O-[2-amino-6-dimethylamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-D-streptamine according to claim 1.
Claim 4
Dependent Claim
5 words
O-[3-Deoxy-4-C-methyl-3-methylamino-β-L-arabinopyranosyl-(1→6)]-O-[2-amino-6-methylamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2,5-dideoxystreptamine according to claim 1.
Claim 5
Dependent Claim
5 words
O-[3-Deoxy-4-C-methyl-3-methylamino-β-L-arabinopyranosyl-(1→6)]-O-[2-amino-6-dimethylamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2,5-dideoxystreptamine according to claim 1.
Claim 6
Dependent Claim
128 words
A process for preparing a compound having the formula: ##STR4## which comprises culturing micromonospora purpurea ATCC 31,849 in a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and either D-streptamine, to prepare, as a major component, the compound where R 2 and R 5 are both hydroxy and R 6 is hydrogen and, as a minor component, the compound where R 2 and R 5 are both hydroxy and R 6 is methyl, or 2,5-dideoxystreptamine, to prepare, as the major component, the compound where R 2 , R 5 and R 6 are each hydrogen and, as a minor component, the compound where R 2 and R 5 are both hydrogen and R 6 is methyl and isolating the said compounds from the nutrient medium.
Claim 7
Dependent Claim
128 words
A process for preparing a compound having the formula: ##STR4## which comprises culturing micromonospora purpurea ATCC 31,849 in a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and either D-streptamine, to prepare, as a major component, the compound where R 2 and R 5 are both hydroxy and R 6 is hydrogen and, as a minor component, the compound where R 2 and R 5 are both hydroxy and R 6 is methyl, or 2,5-dideoxystreptamine, to prepare, as the major component, the compound where R 2 , R 5 and R 6 are each hydrogen and, as a minor component, the compound where R 2 and R 5 are both hydrogen and R 6 is methyl and isolating the said compounds from the nutrient medium.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-24 | 1987-04-25 | 1987-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-24 | 1991-04-25 | 1991-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-24 | 1995-04-25 | 1995-10-25 | $7700.00 | Window Closed / Lapsed |