Branched amides of L-aspartyl-d-amino acid dipeptides

Claim 1

An L-aspartyl-D-amino acid dipeptide amide of the formula ##STR412## and the physiologically acceptable cationic and acid addition salts thereof, wherein R a is methyl, ethyl, n-propyl or isopropyl; and R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR413## where at least one of R 3 , R 4 , R 5 , R 6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, X is O, S, SO, SO 2 , C═O or CHOH; m is zero, 1, 2, 3 or 4, n and p are each zero, 1, 2 or 3 where the sum of n+p is not greater than 3 and the sum of the carbon atoms in R 3 , R 4 , R 5 and R 6 is not greater than six, and when both of R 3 and R 4 or R 5 and R 6 are alkyl they are methyl or ethyl, ##STR414## where one of R 7 , R 8 , R 9 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms and the sum of the carbon atoms in R 7 , R 8 and R 9 is not greater than six, ##STR415## where m and q are the same or different and each have the values previously defined for m, ##STR416## where each of R 12 and R 13 are methyl or ethyl, or R 12 is hydrogen and R 13 is alkyl having from one to four carbon atoms, Z is 0 or NH and t is 1 or 2, ##STR417## where w is 1, 2, 3 or 4, R 14 and R 16 are each alkyl having from one to four carbon atoms, R 15 is hydrogen, OH, or alkyl having from one to two carbon atoms, where the sum of the carbon atoms in R 14 , R 15 and R 16 is not greater than six and when both of R 14 and R 15 are alkyl they are methyl or ethyl, and ##STR418## where R 17 and R 19 are alkyl having from one to four carbon atoms, R 18 and R 20 are hydrogen or alkyl having from one to two carbon atoms, taken separately, A is OH and B is hydrogen, OH or methyl and when taken together A and B are ##STR419## where the sum of the carbon atoms in R 17 , R 18 , R 19 and R 20 is not greater than six and when both of R 17 and R 18 or R 19 and R 20 are alkyl they are methyl or ethyl.