Process for the preparation of N-aryl-N'-(mono- or di substituted)-urea derivatives

Abstract

Abstract The invention relates to a new method for the preparation of N-aryl-N'-(mono- or disubstituted)-urea derivatives having the general formula (I), ##STR1## wherein Aryl is an optionally substituted phenyl group, and R 1 and R 2 each stand for an optionally substituted alkyl, cycloalkyl, alkoxy or phenyl group, or R 1 and R 2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic group which may contain a further hetero atom, or one of R 1 and R 2 may also stand for hydrogen, with the proviso that if one of R 1 and R 2 is an optionally substituted phenyl group, the other may represent only hydrogen atom or an optionally substituted alkyl or alkoxy group, by reacting a carbamate of the general formula (II) with an amine of the general formula (III), R.sup.1 R.sup.2 N--CO--X (II) Aryl--NH.sub.2 (III) or a carbamate of the general formula (IV) with an amine of the general formula (V), Aryl--NH--CO--X (IV) R.sup.1 R.sup.2 NH (V) wherein R 1 , R 2 and Aryl are as defined above and X is a lower alkoxy, phenoxy or substituted phenoxy group, in the presence of a tertiary amine catalyst. According to the invention a tertiary alkylamine containing altogether at least 6 carbon atoms and minimum one alkyl chain with at least 4 carbon atoms or a mixture of such tertiary alkylamines is applied as catalyst.

Inventors

• 👤 Sandor Torok
• 👤 Lajos Voroshazy
• 👤 Peter Galambos
• 👤 Ivan Daroczi
• 👤 Zoltan Ormenyi

Bibliographic Details