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US4409222A
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US
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Pinacidil-diuretic preparation for treating hypertension or congestive heart failure
Assignee: Leo Pharma AS
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Filing: 1982-03-31
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Granted: 1983-10-11
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Expires: 2002-03-31
Abstract
Abstract The present invention relates to a pharmaceutical preparation containing as the vasodilator N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine and as the diuretic active component a compound selected from the group consisting of the thiazide or thiazide-like type diuretics and loop diuretics. The combination is valuable in the treatment of mammals, including man, suffering e.g. from hypertension or congestive heart failure.
Inventors
- 👤 Edoardo Arrigoni-Martelli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 11:39
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/54; A61K31/63; A61K31/635; A61P; A61P9/00; A61P9/08; A61P9/12
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
42 words
A pharmaceutical preparation for treating hypertension or congestive heart failure consisting essentially of an effective amount of a mixture of N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine and a diuretic, the two active components being used as such or, if appropriate, in the form of atoxic salts thereof.
Claim 2
Dependent Claim
42 words
A pharmaceutical preparation for treating hypertension or congestive heart failure consisting essentially of an effective amount of a mixture of N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine and a diuretic, the two active components being used as such or, if appropriate, in the form of atoxic salts thereof.
Claim 3
Dependent Claim
17 words
A preparation as claimed in claim 1, in which the diuretic is a thiazide or thiazide-like diuretic.
Claim 4
Dependent Claim
15 words
A preparation as claimed in claim 1, in which the diuretic is a loop diuretic.
Claim 5
Dependent Claim
13 words
A preparation as claimed in claim 1, in which the diuretic is bendroflumethiazide.
Claim 6
Dependent Claim
13 words
A preparation as claimed in claim 1, in which the diuretic is hydroflumethiazide.
Claim 7
Dependent Claim
13 words
A preparation as claimed in claim 1, in which the diuretic is bumetanide.
Claim 8
Dependent Claim
13 words
A preparation as claimed in claim 1, in which the diuretic is furosemide.
Claim 9
Dependent Claim
10 words
A preparation according to claim 1 in dosage unit form.
Claim 10
Dependent Claim
69 words
A pharmaceutical preparation according to claim 8 for the treatment of patients suffering from hypertension or congestive heart failure which comprises as an active ingredient from not less than 5 mg and up to 50 mg of N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine, as such or as an atoxic salt thereof, and as a further active ingredient from 0.1 to 1000 mg of a diuretic, together with pharmaceutically acceptable, non-toxic carriers and/or auxiliary agents.
Claim 11
Dependent Claim
29 words
A pharmaceutical preparation according to claim 9 in the form of tablets, pills, capsules, or powder for the oral treatment of patients suffering from hypertension or congestive heart failure.
Claim 12
Dependent Claim
30 words
A method of treating mammals, including man, suffering from hypertension or congestive heart failure, which comprises administering to the patient an effective amount of a preparation according to claim 1.
Claim 13
Dependent Claim
17 words
A method according to claim 11 using a preparation in dosage unit form according to claim 8.
Claim 14
Dependent Claim
44 words
A method for the treatment of hypertension or congestive heart failure in mammals, including man, comprising simultaneous administration to a host suffering from said illness a therapeutically acceptable amount of N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine and a therapeutically acceptable amount of a diuretic as specified in claim 1.
Claim 15
Dependent Claim
47 words
A method for the treatment of hypertension or congestive heart failure in mammals, including man, comprising sequentially administering to a host suffering from hypertension or congestive heart failure a therapeutically acceptable amount of N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine and a therapeutically acceptable amount of a diuretic as specified in claim 1.
References Cited (Backward Citations)
US4057636A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-10 | 1987-04-11 | 1987-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-10 | 1991-04-11 | 1991-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-10 | 1995-04-11 | 1995-10-11 | $7700.00 | Window Closed / Lapsed |