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Patent US4404365A successfully refreshed from Google Patents.
US4404365A
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Modulators of the complement system
Assignee: Wyeth Holdings LLC
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Filing: 1981-12-28
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Granted: 1983-09-13
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Expires: 2001-12-28
Abstract
Abstract Bis-[ beta -D-glucopyranosyl-1-thio (or sulfinyl or sulfonyl)]-arylene sulfate derivatives, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process for the preparation of such intermediates and end products.
Inventors
- 👤 Thomas G. Miner
- 👤 Seymour Bernstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 14:00
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/203; C07H11/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
132 words
A compound selected from those of the formula: ##STR5## wherein X is --SO 3 M and M is a nontoxic pharmaceutically acceptable cation salt, wherein the salt forming moiety is selected from the group consisting of alkali metal, alkaline earth metal, ammonia and substituted ammonia selected from the group consisting of trialkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 2 -C 6 ) and cycloalkylamine (C 3 -C 6 ); R 1 is selected from the group consisting of CH 2 OX, COOH and COONa; R 2 is selected from the group consisting of OX and NHCOCH 3 ; A is selected from the group consisting of S, SO, and SO 2 ; n is an integer 2; and B is an arylene selected from the group consisting of: ##STR6##
Claim 2
Dependent Claim
132 words
A compound selected from those of the formula: ##STR5## wherein X is --SO 3 M and M is a nontoxic pharmaceutically acceptable cation salt, wherein the salt forming moiety is selected from the group consisting of alkali metal, alkaline earth metal, ammonia and substituted ammonia selected from the group consisting of trialkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 2 -C 6 ) and cycloalkylamine (C 3 -C 6 ); R 1 is selected from the group consisting of CH 2 OX, COOH and COONa; R 2 is selected from the group consisting of OX and NHCOCH 3 ; A is selected from the group consisting of S, SO, and SO 2 ; n is an integer 2; and B is an arylene selected from the group consisting of: ##STR6##
Claim 3
Dependent Claim
28 words
The compound according to claim 1, oxydi-p-phenylene bis-[1-thio-β-D-glucopyranoside], octakis(H-sulfate), octatriethylamine salt, where the structure is ##STR7## wherein M is N + H(C 2 H 5 ) 3 .
Claim 4
Dependent Claim
16 words
The compound according to claim 1, oxydi-p-phenylene bis-[1-thio-β-D-glucopyranoside], octakis(H-sulfate), octasodium salt, where the structure is ##STR8##
Claim 5
Dependent Claim
28 words
The compound according to claim 1, 1,3-bis-[β-D-glucopyranosiduronic acid-1-thio]-phenylene, hexakis(H-sulfate), hexatriethylamine salt, where the structure is ##STR9## wherein M is N + H(C 2 H 5 ) 3 .
Claim 6
Dependent Claim
16 words
The compound according to claim 1, 1,3-bis-[β-D-glucopyranosiduronic acid-1-thio]-phenylene, hexakis(H-sulfate), octasodium salt, where the structure is ##STR10##
Claim 7
Dependent Claim
27 words
The compound according to claim 1, 1,3-bis-[β-D-(2-acetylamino)-glucopyranosyl-1-thio]-phenylene, hexakis(H-sulfate), hexatriethylamine salt, where the structure is ##STR11## wherein M is N + H(C 2 H 5 ) 3 .
Claim 8
Dependent Claim
15 words
The compound according to claim 1, 1,3-bis-[β-D-(2-acetylamino)-glucopyranosyl-1-thio]-phenylene, hexakis(H-sulfate), hexasodium salt, where the structure is ##STR12##
References Cited (Backward Citations)
US4021544A
Cited
US4304903A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-12 | 1987-03-14 | 1987-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-12 | 1991-03-14 | 1991-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-12 | 1995-03-14 | 1995-09-13 | $7700.00 | Window Closed / Lapsed |