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Antimicrobial compositions containing 1-ethyl-6-fluoro-1,4-dihydro-4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or metal salts thereof and silver sulfadiazine

Assignee: RESEARCH Corp A NEW YORK NOT-FOR-PROFIT CORP
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Filing: 1981-05-15
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Granted: 1983-09-13
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Expires: 2001-05-15
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Abstract

Abstract Compositions which include 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or its metal salts, e.g., silver, zinc, cobalt or cerium salts, and silver sulfadiazine are effective in the treatment of burns. Of special interest are compositions containing silver sulfadiazine and the silver salt of the above-identified quinoline carboxylic acid, wherein even though each compound is present in a concentration which would be ineffective if either compound were present alone, the resulting compositions are effective. The compositions of this invention may be applied to the affected surface of a burn victim either directly or in combination with a physiologically acceptable carrier, such as a water-dispersible, hydrophilic carrier.

Inventors

  • 👤 Charles L. Fox, Jr.
  • 👤 Shanta M. Modak

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 06:10
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/63; A61K31/635

Claims Analysis

Total Claims: 3
Claim 1
Independent Claim 27 words
A composition useful in burn therapy which comprises about 3 mM silver salt of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid, about 30 mM silver sulfadiazine, and a physiologically acceptable carrier.
Claim 2
Dependent Claim 27 words
A composition useful in burn therapy which comprises about 3 mM silver salt of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid, about 30 mM silver sulfadiazine, and a physiologically acceptable carrier.
Claim 3
Dependent Claim 22 words
A method of treating burns in animal or man which comprises topically applying the composition of claim 1 to the affected surface.

References Cited (Backward Citations)

US3761590A Cited
US4146719A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1986-09-12 1987-03-14 1987-09-13 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1990-09-12 1991-03-14 1991-09-13 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1994-09-12 1995-03-14 1995-09-13 $7700.00 Window Closed / Lapsed

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