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US4404187A
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Method for rendering factors II and VII hepatitis-safe with a chelating agent
Assignee: Esselte Pendaflex Corp
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Filing: 1981-11-19
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Granted: 1983-09-13
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Expires: 2001-11-19
Abstract
Abstract What is disclosed is a method for treating a preparation containing blood clotting Factors II and/or VII to render it virtually hepatitis-free by warming said preparation in the presence of a chelating agent and in the further presence of an amino acid and/or a saccharide or sugar alcohol.
Inventors
- 👤 Horst Schwinn
- 👤 Norbert Heimburger
- 👤 Gerhardt Kumpe
- 👤 Hans M. Preis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 23:29
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/6437; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61L; A61L2/00; A61L2/02; A61L2/04; C12Y; C12Y304/00; C12Y304/21; C12Y304/21021; A61L2103/00; A61L2103/05; A61L2103/09
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
67 words
A method for making a preparation containing at least one member selected from the group consisting of blood clotting Factor II and blood clotting factor VII virtually hepatitis-safe, which method comprises warming said preparation in the presence of an effective amount of a chelating agent and in the further presence of at least one member selected from the group consisting of amino acids, saccharides, and sugar alcohols.
Claim 2
Independent Claim
67 words
A method for making a preparation containing at least one member selected from the group consisting of blood clotting Factor II and blood clotting factor VII virtually hepatitis-safe, which method comprises warming said preparation in the presence of an effective amount of a chelating agent and in the further presence of at least one member selected from the group consisting of amino acids, saccharides, and sugar alcohols.
Claim 3
Dependent Claim
21 words
A method as in claim 1 wherein said chelating agent is present at a concentration from 0.1 mole/liter to 1 mole/liter.
Claim 4
Dependent Claim
23 words
A method as in claim 1 wherein said chelating agent is the sodium salt of ethylenediamine-tetraacetic acid or of ethylene glycol-bis-(2-aminoethyl ether)-tetraacetic acid.
Claim 5
Dependent Claim
38 words
A method as in claim 1 wherein said chelating agent is present at a concentration from 0.01 mole/liter to 3.0 moles/liter and said preparation is warmed at 30° C. to 100° C. for 1 minute to 48 hours.
Claim 6
Dependent Claim
69 words
A method as in claim 4 wherein said warming is carried out in the additional presence of 1.0 mole/liter to 3.0 moles/liter of at least one amino acid selected from the group consisting of glycine, α-alanine, β-alanine, hydroxyproline, proline, glutamine, and α-, β-, and γ- aminobutyric acids and of 20 to 60 percent by weight of a member selected from the group consisting of monosaccharides, oligosaccharides, and sugar alcohols.
References Cited (Backward Citations)
US4327086A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-12 | 1987-03-14 | 1987-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-12 | 1991-03-14 | 1991-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-12 | 1995-03-14 | 1995-09-13 | $7700.00 | Window Closed / Lapsed |