Patent US4402940A successfully refreshed from Google Patents.
US4402940A
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Method for treating blood plasma employing a hollow fiber membrane
Assignee: Kuraray Co Ltd
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Filing: 1982-09-17
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Granted: 1983-09-06
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Expires: 2002-09-17
Abstract
Abstract This invention provides a method for treating blood plasma wherein a hollow fiber membrane which comprises at least a skin layer on one surface of the membrane and also a porous layer inside the membrane is employed. The skin layer of the membrane has micropores with average pore size of 50 to 450 A, and the membrane shows a water permeability of 80 ml/m 2 .hr.mmHg or more, and permeabilites for human blood plasma albumin of 85% or more and for human blood plasma immunoglobulin G(IgG) of 80% or more, and a rate of inhibition against human blood plasma immunoglobulin M(IgM) of 40% or more. Use of the above mentioned hollow fiber membrane, which makes it possible to selectively remove immune complex, rheumatoid factors, etc., without decrease in levels of immunological functions, brings excellent effects on therapy of autoimmune diseases.
Inventors
- 👤 Yukihiko Nose
- 👤 Koji Kayashima
- 👤 Akinori Sueoka
- 👤 Yoshihiro Asanuma
- 👤 Shigeru Shinagawa
- 👤 James Smith
- 👤 Andrej Werynski
- 👤 Paul S. Malchesky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 08:14
CPC Classifications
B; B01; B01D; B01D69/00; B01D69/08; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61M; A61M1/00; A61M1/34; A61M1/3472; A61M1/3482; B01D69/02
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
117 words
A method for treating the blood plasma to selectively reduce the amount of a disease factor therein comprising fractionating the plasma with a hollow fiber membrane comprising a skin layer on at least one surface of said membrane and a porous layer inside said membrane with average pore size of micropores of said skin layer in the range of 50 to 450 A, that of micropores of the porous layer ranging from 500 to 15,000 A, void volume of said membrane at a level of 50 to 85% and water permeability at a level of 80 ml/m 2 .hr.mmHg or higher, such that the amount of the disease factor in one of the fractions produced is decreased.
Claim 2
Independent Claim
117 words
A method for treating the blood plasma to selectively reduce the amount of a disease factor therein comprising fractionating the plasma with a hollow fiber membrane comprising a skin layer on at least one surface of said membrane and a porous layer inside said membrane with average pore size of micropores of said skin layer in the range of 50 to 450 A, that of micropores of the porous layer ranging from 500 to 15,000 A, void volume of said membrane at a level of 50 to 85% and water permeability at a level of 80 ml/m 2 .hr.mmHg or higher, such that the amount of the disease factor in one of the fractions produced is decreased.
Claim 3
Dependent Claim
40 words
A method for treating the blood plasma as claimed in claim 1, wherein said hollow fiber membrane has a skin layer on its exterior surface and a porous supporting layer both inside and on the interior surface of said membrane.
Claim 4
Dependent Claim
57 words
A method for treating the blood plasma as claimed in claim 1 or claim 2, wherein said hollow fiber membrane shows permeabilities for human blood plasma albumin and human blood plasma immunoglobulin G of 85% or more and 80% or more, respectively, and a rate of inhibition against human blood plasma immunoglobulin M of 40% or more.
Claim 5
Independent Claim
32 words
A method for treating the blood plasma as claimed in any one of claims 1 to 3, wherein the skin layer of said hollow fiber membrane is 100 to 30,000 A thick.
Claim 6
Independent Claim
40 words
A method for treating the blood plasma as claimed in any one of claims 1 to 4, wherein thickness of the hollow fiber membrane ranges 10 to 90μ and inside diameter thereof is in the range of 50 to 800μ.
Claim 7
Independent Claim
31 words
A method for treating the blood plasma as claimed in any one of claims 1 to 5, wherein water permeability is in the range of 80 to 1,500 ml/m 2 .hr.mmHg.
Claim 8
Independent Claim
29 words
A method for treating the blood plasma as claimed in any one of claims 1 to 6, wherein the hollow fiber membrane is composed of a vinyl alcohol polymer.
Claim 9
Dependent Claim
22 words
A method for treating the blood plasma as claimed in claim 7, wherein said vinyl alcohol polymer is an ethylene-vinyl alcohol copolymer.
References Cited (Backward Citations)
US3002887A
Cited
US4321192A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-05 | 1987-03-07 | 1987-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-05 | 1991-03-07 | 1991-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-05 | 1995-03-07 | 1995-09-06 | $7700.00 | Window Closed / Lapsed |