US4402318A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for inactivating viruses, bacteria, etc. in vitro and production of vaccines
Assignee: Individual
•
Filing: 1981-05-29
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Granted: 1983-09-06
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Expires: 2001-05-29
Abstract
Abstract A method of inactivating viruses, bacteria, cells, toxins, etc., in vitro is disclosed. The disclosed method involves introducing an active agent capable of assuming an excited state when subjected to light, e.g., methylene blue, into the material to be inactivated. The virus, bacteria, etc. is then subjected to concurrent application of an electric field and light for inactivation.
Inventors
- 👤 Mitchell R. Swartz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:26
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61K; A61K41/00; A61K41/10; A61K41/17; A61L2/16; A61N; A61N1/00; A61N1/40; A61N5/00; A61N5/06; A61N5/0613; A61N5/062; C; C01; C01B; C01B15/00; C01B15/01; C12; C12N; C12N13/00; C12N7/00; G; G01; G01N; G01N33/00; G01N33/0004; G01N33/0009; G01N33/007; A61N2005/0635; A61N2005/0643; A61N2005/0644; A61N2005/065; A61N2005/0651; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16611; C12N2710/16661
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
61 words
A method of inactivating viruses, bacteria, cells, toxins or the like, in vitro, that comprises introducing to the viruses, bacteria, cells, toxins or the like, an active component capable of assuming an excited electronic state when subjected to light and an electric field concurrently, and concurrently applying an electric field and light to said viruses, bacteria cells, toxins or the like.
Claim 2
Independent Claim
61 words
A method of inactivating viruses, bacteria, cells, toxins or the like, in vitro, that comprises introducing to the viruses, bacteria, cells, toxins or the like, an active component capable of assuming an excited electronic state when subjected to light and an electric field concurrently, and concurrently applying an electric field and light to said viruses, bacteria cells, toxins or the like.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein said active component is a photoactive dye.
Claim 4
Dependent Claim
12 words
The method of claim 2 wherein said photoactive dye is methylene blue.
Claim 5
Independent Claim
82 words
A method for producing a vaccine in vitro comprising introducing, to viruses, bacteria, cells, toxins or the like, an active component capable of assuming an excited electronic state when subjected to light and an electric field concurrently, and concurrently applying an electric field and light to said viruses, bacteria, cells, toxins or the like, and terminating said concurrent application of the electric field and light prior to complete inactivation of said viruses, bacteria, cells, toxins of the like, to produce the vaccine.
Claim 6
Independent Claim
82 words
A method for producing a vaccine in vitro comprising introducing, to viruses, bacteria, cells, toxins or the like, an active component capable of assuming an excited electronic state when subjected to light and an electric field concurrently, and concurrently applying an electric field and light to said viruses, bacteria, cells, toxins or the like, and terminating said concurrent application of the electric field and light prior to complete inactivation of said viruses, bacteria, cells, toxins of the like, to produce the vaccine.
Claim 7
Dependent Claim
13 words
The method of claim 4 wherein said active component is a photoactive dye.
Claim 8
Dependent Claim
12 words
The method of claim 5 wherein said photoactive dye is methylene blue.
References Cited (Backward Citations)
US4181128A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-05 | 1987-03-07 | 1987-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-05 | 1991-03-07 | 1991-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-05 | 1995-03-07 | 1995-09-06 | $7700.00 | Window Closed / Lapsed |