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Patent US4401653A successfully refreshed from Google Patents.
US4401653A
Expired / Lapsed
US
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Combination of rapamycin and picibanil for the treatment of tumors
Assignee: Wyeth Canada Inc
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Filing: 1981-03-09
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Granted: 1983-08-30
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Expires: 2001-03-09
Abstract
Abstract Described is a method of using a combination of rapamycin and picibanil for the treatment of transplantable carcinogenic tumors.
Inventors
- 👤 Chee P. Eng
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:00
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/04; A61P; A61P35/00; A61P35/02
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
96 words
A method of reducing tumor size in a tumor bearing mammal or prolonging the survival time in a tumor bearing mammal, wherein said tumor is a transplantable tumor selected from the group consisting of lymphatic leukemia, colon, mammary, meleanocarcinoma and ependymoblastoma, which comprises administering to said mammal an antitumor effective amount of a combination of rapamycin and picibanil, said rapamycin being administered at a daily dose of from 10 to 250 mg per kg of body weight and said picibanil being administered at a daily dose of 0.5 to 5 KE per kg of body weight.
Claim 2
Independent Claim
96 words
A method of reducing tumor size in a tumor bearing mammal or prolonging the survival time in a tumor bearing mammal, wherein said tumor is a transplantable tumor selected from the group consisting of lymphatic leukemia, colon, mammary, meleanocarcinoma and ependymoblastoma, which comprises administering to said mammal an antitumor effective amount of a combination of rapamycin and picibanil, said rapamycin being administered at a daily dose of from 10 to 250 mg per kg of body weight and said picibanil being administered at a daily dose of 0.5 to 5 KE per kg of body weight.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said tumor is lymphocytic leukemia.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein rapamycin and picibanil are administered parenterally.
Claim 5
Dependent Claim
14 words
The method of claim 1 wherein rapamycin and picibanil are administered sequentially or simultaneously.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-29 | 1987-02-28 | 1987-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-29 | 1991-02-28 | 1991-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-29 | 1995-02-28 | 1995-08-30 | $7700.00 | Window Closed / Lapsed |