Patent US4401594A successfully refreshed from Google Patents.
US4401594A
Expired / Lapsed
US
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L-Argininal derivatives and a method of manufacturing the same
Assignee: Nippon Kayaku Co Ltd
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Filing: 1981-09-08
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Granted: 1983-08-30
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Expires: 2001-09-08
Abstract
Abstract L-Argininal derivatives of the general formula: <IMAGE> are disclosed. A method of manufacturing any such derivative is also disclosed. The L-argininal derivative of this invention has a strong inhibitory activity on proteases, such as serine and thiol proteases, and is expected to provide useful medicines, including those which are effective for diseases caused by abnormal elevation of protease activity.
Inventors
- 👤 Hamao Umezawa
- 👤 Tomio Takeuchi
- 👤 Takaaki Aoyagi
- 👤 Shinichi Ishii
- 👤 Tetsushi Saino
- 👤 Tetsuya Someno
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 11:05
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06139; C07K5/06165; A; A61; A61P; A61P37/00; C07K5/06008; C07K5/06017; C07K5/06034; C07K5/06043; C07K5/06173; C07K5/08; C07K5/0802; C07K5/0812; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
40 words
An L-argininal derivative of the general formula: ##STR3## in which R" is a group selected from the group consisting of n-nonanoyl, m-chlorbenzoyl, p-methylbenzoyl, p-methoxybenzoyl, p-nitrobenzoyl, benzenesulfonyl, 2-naphthalenecarbonyl, 1-naphthalenesulfonyl, mandelyl, p-nitrophenylacetyl, L-nicotinyl, N-benzyloxycarbonyl-L-phenylalanyl, N-benzyloxycarbonyl-3-amino-2-hydroxy-4-phenylbutanoyl, N-benzyloxycarbonyl-L-prolyl, L-prolyl, N-benzyloxycarbonylpyroglutamyl, L-pyroglutamyl, p-toluenesulfonyl, and pipecolyl.
Claim 2
Dependent Claim
40 words
An L-argininal derivative of the general formula: ##STR3## in which R" is a group selected from the group consisting of n-nonanoyl, m-chlorbenzoyl, p-methylbenzoyl, p-methoxybenzoyl, p-nitrobenzoyl, benzenesulfonyl, 2-naphthalenecarbonyl, 1-naphthalenesulfonyl, mandelyl, p-nitrophenylacetyl, L-nicotinyl, N-benzyloxycarbonyl-L-phenylalanyl, N-benzyloxycarbonyl-3-amino-2-hydroxy-4-phenylbutanoyl, N-benzyloxycarbonyl-L-prolyl, L-prolyl, N-benzyloxycarbonylpyroglutamyl, L-pyroglutamyl, p-toluenesulfonyl, and pipecolyl.
Claim 3
Dependent Claim
1 words
n-Nonanoyl-L-leucyl-L-argininal.
Claim 4
Dependent Claim
1 words
n-Nonanoyl-L-leucyl-L-argininal.
Claim 5
Dependent Claim
1 words
p-Nitrophenylacetyl-L-leucyl-L-argininal.
Claim 6
Dependent Claim
1 words
p-Nitrophenylacetyl-L-leucyl-L-argininal.
Claim 7
Dependent Claim
1 words
Nicotinyl-L-leucyl-L-argininal.
Claim 8
Dependent Claim
1 words
Nicotinyl-L-leucyl-L-argininal.
Claim 9
Dependent Claim
1 words
N-Benzyloxycarbonyl-L-phenylalanyl-L-leucyl-L-argininal.
Claim 10
Dependent Claim
1 words
N-Benzyloxycarbonyl-L-phenylalanyl-L-leucyl-L-argininal.
Claim 11
Dependent Claim
1 words
N-Benzyloxycarbonyl-L-pyroglutamyl-L-leucyl-L-leucyl-L-argininal.
Claim 12
Dependent Claim
1 words
N-Benzyloxycarbonyl-L-pyroglutamyl-L-leucyl-L-leucyl-L-argininal.
Claim 13
Dependent Claim
1 words
L-Pyroglutamyl-L-leucyl-L-argininal.
Claim 14
Dependent Claim
1 words
L-Pyroglutamyl-L-leucyl-L-argininal.
Claim 15
Dependent Claim
1 words
5-Dimethylamino-1-naphthalenesulfonyl-L-leucyl-L-argininal.
Claim 16
Dependent Claim
1 words
5-Dimethylamino-1-naphthalenesulfonyl-L-leucyl-L-argininal.
References Cited (Backward Citations)
US3840513A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-29 | 1987-02-28 | 1987-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-29 | 1991-02-28 | 1991-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-29 | 1995-02-28 | 1995-08-30 | $7700.00 | Window Closed / Lapsed |