Patent US4399151A successfully refreshed from Google Patents.
US4399151A
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Method of inhibiting the growth of protozoa
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1981-05-11
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Granted: 1983-08-16
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Expires: 2001-05-11
Abstract
Abstract alpha -Substituted amines and alpha -substituted- alpha -amino acids are described which are useful in inhibiting the growth of protozoa in animals.
Inventors
- 👤 Albert Sjoerdsma
- 👤 Peter P. McCann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:07
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A23; A23K; A23K20/00; A23K20/10; A23K20/105; A23K20/116; A23K20/132; A61K31/185; A61K31/19; A61K31/195; A61K31/33; A61K31/395; A61K31/495; A61K31/505
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
104 words
A method of inhibiting the growth of protozoa in animals which comprises administering a protozoal inhibiting amount of an α-substituted amino acid or an α-substituted amine having the formula ##STR35## wherein R 1 is hydrogen or carboxy; Y is selected from the group consisting of CH 2 F, CHF 2 , CF 3 and C.tbd.CH; Z is selected from the group consisting of H 2 N--(CH 2 ) 3 , ##STR36## and H 2 N-CH 2 CH═CH; with the proviso that when R 1 is hydrogen, Y cannot be CF 3 and Z must be ##STR37## and the salts and individual optical isomers thereof.
Claim 2
Independent Claim
104 words
A method of inhibiting the growth of protozoa in animals which comprises administering a protozoal inhibiting amount of an α-substituted amino acid or an α-substituted amine having the formula ##STR35## wherein R 1 is hydrogen or carboxy; Y is selected from the group consisting of CH 2 F, CHF 2 , CF 3 and C.tbd.CH; Z is selected from the group consisting of H 2 N--(CH 2 ) 3 , ##STR36## and H 2 N-CH 2 CH═CH; with the proviso that when R 1 is hydrogen, Y cannot be CF 3 and Z must be ##STR37## and the salts and individual optical isomers thereof.
Claim 3
Dependent Claim
11 words
A method according to claim 1 wherein R 1 is hydrogen.
Claim 4
Dependent Claim
11 words
A method according to claim 1 wherein R 1 is carboxy.
Claim 5
Dependent Claim
18 words
A method according to claim 1 wherein Z is ##STR38## or H 2 N--(CH 2 ) 3 .
Claim 6
Dependent Claim
12 words
A method according to claim 1 wherein Y is CHF 2 .
Claim 7
Dependent Claim
33 words
A method according to claim 1 wherein the animals are fowl and the α-substituted amino acid or α-substituted amine is administered to their drinking water at a concentration of from 0.01% to 2.0%.
Claim 8
Dependent Claim
24 words
The method according to claim 6 wherein the α-substituted amino acid or α-substituted amine is administered at a concentration of from 0.06% to 1.0%.
Claim 9
Independent Claim
120 words
A method of inhibiting the growth of protozoa in animals which comprises administering a protozoal inhibiting amount of an α-substituted amino acid or an α-substituted amine having the formula ##STR39## wherein R 1 is hydrogen or carboxy; Y is selected from the group consisting of CH 2 F, CHF 2 , CF 3 and C.tbd.CH; is selected from the group consisting of H 2 N--(CH 2 ) 3 , ##STR40## and H 2 N-CH 2 CH═CH; with the proviso that when R 1 is hydrogen, Y cannot be CF 3 and Z must be ##STR41## and the salts and individual optical isomers thereof in combination with an antiprotozoal agent selected from the group consisting of Antrycide, Pentamidine, Amicarbalide and Bleomycin.
Claim 10
Independent Claim
120 words
A method of inhibiting the growth of protozoa in animals which comprises administering a protozoal inhibiting amount of an α-substituted amino acid or an α-substituted amine having the formula ##STR39## wherein R 1 is hydrogen or carboxy; Y is selected from the group consisting of CH 2 F, CHF 2 , CF 3 and C.tbd.CH; is selected from the group consisting of H 2 N--(CH 2 ) 3 , ##STR40## and H 2 N-CH 2 CH═CH; with the proviso that when R 1 is hydrogen, Y cannot be CF 3 and Z must be ##STR41## and the salts and individual optical isomers thereof in combination with an antiprotozoal agent selected from the group consisting of Antrycide, Pentamidine, Amicarbalide and Bleomycin.
Claim 11
Dependent Claim
11 words
A method according to claim 8 wherein R 1 is hydrogen.
Claim 12
Dependent Claim
11 words
A method according to claim 8 wherein R 1 is carboxy.
Claim 13
Dependent Claim
18 words
A method according to claim 8 wherein Z is ##STR42## or H 2 N-(CH 2 ) 3 .
Claim 14
Dependent Claim
12 words
A method according to claim 8 wherein Y is CHF 2 .
Claim 15
Dependent Claim
33 words
A method according to claim 8 wherein the animals are fowl and the α-substituted amino acid or α-substituted amine is administered to their drinking water at a concentration of from 0.01% to 2.0%.
Claim 16
Dependent Claim
24 words
A method according to claim 13 wherein the α-substituted amino acid or α-substituted amine is administered at a concentration of from 0.06% to 1.0%.
Claim 17
Dependent Claim
12 words
A method according to claim 1 wherein Y is CH 2 F.
Claim 18
Dependent Claim
12 words
A method according to claim 8 wherein Y is CH 2 F.
References Cited (Backward Citations)
US4267374A
Cited
BE868882A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1986-08-15 | 1987-02-14 | 1987-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-15 | 1991-02-14 | 1991-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-15 | 1995-02-14 | 1995-08-16 | $7700.00 | Window Closed / Lapsed |