US4399127A
Expired / Lapsed
US
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Injectable oxytetracycline compositions
Assignee: Fermenta Animal Health Co
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Filing: 1981-09-08
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Granted: 1983-08-16
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Expires: 2001-09-08
Abstract
Abstract Increased antibiotic content of oxytetracycline injectable compositions containing glycerol formal as the solvent is achieved by utilization of particular magnesium compounds, viz., magnesium oxide, magnesium hydroxide, magnesium carbonate, magnesium acetate and magnesium chloride. Magnesium chloride is utilized with oxytetracycline base only.
Inventors
- 👤 Walter Hacke
- 👤 Herman Horn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 12:24
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/22; A61K47/02; A61K9/00; A61K9/0012; A61K9/0019
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
144 words
A stable, injectable antibiotic composition of increased antibiotic concentration for parenteral administration comprising: (a) from about 15 to about 35 parts by weight of an antibiotic selected from the group consisting of oxytetracycline base and an acid addition salt thereof, (b) a magnesium compound selected from the group consisting of magnesium oxide, magnesium hydroxide and magnesium carbonate present in a molar ratio from about 0.8 to about 1.2 moles per mole of said antibiotic, (c) from about 50 to about 95 parts by weight of glycerol formal selected from the group consisting of 4-hydroxymethyl-1,3-dioxolane, 5-hydroxy-1,3-dioxane and mixtures thereof, (d) from about 10 to about 45 parts by weight of water, (e) an antioxidant in an amount sufficient to stabilize said composition, and (f) a buffering agent in an amount sufficient to provide a pH of from about 6 to about 9.5 in said composition.
Claim 2
Dependent Claim
144 words
A stable, injectable antibiotic composition of increased antibiotic concentration for parenteral administration comprising: (a) from about 15 to about 35 parts by weight of an antibiotic selected from the group consisting of oxytetracycline base and an acid addition salt thereof, (b) a magnesium compound selected from the group consisting of magnesium oxide, magnesium hydroxide and magnesium carbonate present in a molar ratio from about 0.8 to about 1.2 moles per mole of said antibiotic, (c) from about 50 to about 95 parts by weight of glycerol formal selected from the group consisting of 4-hydroxymethyl-1,3-dioxolane, 5-hydroxy-1,3-dioxane and mixtures thereof, (d) from about 10 to about 45 parts by weight of water, (e) an antioxidant in an amount sufficient to stabilize said composition, and (f) a buffering agent in an amount sufficient to provide a pH of from about 6 to about 9.5 in said composition.
Claim 3
Dependent Claim
28 words
The composition of claim 1 wherein said antibiotic is oxytetracycline base, said magnesium compound is magnesium oxide and said glycerol formal is a mixture of 4-hydroxymethyl-1,3-dioxolane and 5-hydroxy-1,3-dioxane.
Claim 4
Dependent Claim
28 words
The composition of claim 1 wherein said antibiotic is oxytetracycline hydrochloride, said magnesium compound is magnesium oxide and said glycerol formal is a mixture of 4-hydroxymethyl-1,3-dioxolane and 5-hydroxy-1,3-dioxane.
Claim 5
Dependent Claim
22 words
The composition of claim 2 wherein the mole ratio of said magnesium compound to said oxytetracycline base is about 1 to 1.
Claim 6
Dependent Claim
22 words
The composition of claim 4 wherein the amount of oxytetracycline base present is about 20 % by weight of the total composition.
Claim 7
Dependent Claim
21 words
The composition of claim 3 wherein the mole ratio of said magnesium compound to said oxytetracycline hydrochloride is 0.8 to 1.
Claim 8
Dependent Claim
11 words
The composition of claim 1 wherein said antioxidant is sodium formaldehydesulfoxylate.
Claim 9
Dependent Claim
11 words
The composition of claim 1 wherein said buffering agent is monoethanolamine.
Claim 10
Dependent Claim
15 words
The composition of claim 1 wherein substantially all particles thereof are smaller than 0.20 microns.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-15 | 1987-02-14 | 1987-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-15 | 1991-02-14 | 1991-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-15 | 1995-02-14 | 1995-08-16 | $7700.00 | Window Closed / Lapsed |