US4399125A
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Novel antagonists of the antidiuretic action of arginine vasopressin
Assignee: Individual
•
Filing: 1981-11-16
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Granted: 1983-08-16
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Expires: 2001-11-16
Abstract
Abstract Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula <IMAGE> wherein X is D-Phe, D-Val, D-Leu, D-Ile, D-Arg, D-norvaline, D-norleucine, D-cyclohexylalanine, D- alpha -aminobutyric acid, D-threonine or D-methionine and Z is D- or L-Arg.
Inventors
- 👤 Maurice Manning
- 👤 Wilbur H. Sawyer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 12:49
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/16; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/15
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
28 words
A compound of the formula ##STR4## wherein X is D-Phe, D-Val, D-Leu, D-Ile, D-Arg, D-norvaline, D-norleucine, D-cyclohexylalanine, D-α-aminobutyric acid, D-threonine or D-methionine and Z is D- or L-Arg.
Claim 2
Dependent Claim
28 words
A compound of the formula ##STR4## wherein X is D-Phe, D-Val, D-Leu, D-Ile, D-Arg, D-norvaline, D-norleucine, D-cyclohexylalanine, D-α-aminobutyric acid, D-threonine or D-methionine and Z is D- or L-Arg.
Claim 3
Dependent Claim
13 words
A compound of claim 1, wherein X is D-Phe, D-Val, D-Leu or D-Ile.
Claim 4
Dependent Claim
9 words
A compound of claim 1, wherein Z is L-Arg.
Claim 5
Dependent Claim
10 words
[1-(β-Mercapto-β,β-cyclopentamethylenepropionic acid), 2-D-phenylalanine, 4-valine]-arginine vasopressin, a compound of claim 1.
Claim 6
Dependent Claim
10 words
[1-(β-Mercapto-β,β-cyclopentamethylenepropionic acid), 2-D-valine, 4-valine]-arginine vasopressin, a compound of claim 1.
Claim 7
Dependent Claim
10 words
[1-(β-Mercapto-β,β-cyclopentamethylenepropionic acid), 2-D-leucine, 4-valine]-arginine vasopressin, a compound of claim 1.
Claim 8
Dependent Claim
10 words
[1-(β-Mercapto-β,β-cyclopentamethylenepropionic acid), 2-D-isoleucine, 4-valine]-arginine vasopressin, a compound of claim 1.
Claim 9
Dependent Claim
11 words
[1-(β-Mercapto-β,β-cyclopentamethylenepropionic acid), 2-D-phenylalanine, 4-valine, 8-D-arginine] vasopressin, a compound of claim 1.
Claim 10
Dependent Claim
53 words
A method for antagonizing the in vivo response of an animal to the antidiuretic action of an antidiuretic hormone, comprising administering to the animal being treated an amount of a compound of claim 1, in admixture with a physiologically and pharmaceutically acceptable carrier, effective to antagonize the antidiuretic response to the antidiuretic hormone.
Claim 11
Dependent Claim
12 words
The method of claim 9, wherein the antiduretic hormone is arginine vasopressin.
Claim 12
Dependent Claim
11 words
The method of claim 9, wherein the compound is administered parenterally.
Claim 13
Dependent Claim
53 words
A method for antagonizing the in vivo response of an animal to the antidiuretic action of an antidiuretic hormone, comprising administering to the animal being treated an amount of the compound of claim 7, in admixture with a physiologically and pharmaceutically acceptable carrier, effective to antagonize the antidiuretic response to the antidiuretic hormone.
Claim 14
Dependent Claim
53 words
A method for antagonizing the in vivo response of an animal to the antidiuretic action of an antidiuretic hormone, comprising administering to the animal being treated an amount of the compound of claim 4, in admixture with a physiologically and pharmaceutically acceptable carrier, effective to antagonize the antidiuretic response to the antidiuretic hormone.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-15 | 1987-02-14 | 1987-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-15 | 1991-02-14 | 1991-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-15 | 1995-02-14 | 1995-08-16 | $7700.00 | Window Closed / Lapsed |