US4148787A
Expired / Lapsed
US
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Antidiuretically effective polypeptide and a process for preparing the same
Assignee: Ferring AB
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Filing: 1977-11-08
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Granted: 1979-04-10
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Expires: 1997-11-08
Abstract
Abstract Antidiuretically effective vasopressin derivates of the formula ##STR1## in which Mep is a 2-mercaptopropionyl residue (--S--CH 2 CH 2 CO--), and A and B are glutamine (Gln) or asparagine (Asn) and A is Gln only when B is Gln and D-arginine is in position 8. A method for preparing the derivatives comprises the steps of gradually producing the amino acid sequence Mep(SH)--Tyr--Phe--A--B--Cys(SH)--Pro--D--Arg--Gly--NH.sub.2 and thereafter oxidizing this amino acid sequence to the desired vasopressin derivative of the formula (I).
Inventors
- 👤 Jan L. Mulder, deceased
- 👤 Lars A. I. Carlsson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 18:36
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/16; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/15
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
36 words
A desamino-D-arginine 8 -vasopressin derivative, wherein the derivative has the formula ##STR6## in which Mep is 2-mercaptopropionyl and A and B are glutamine (Gln) or asparagine (Asn) and A is Gln only when B is Gln.
Claim 2
Dependent Claim
36 words
A desamino-D-arginine 8 -vasopressin derivative, wherein the derivative has the formula ##STR6## in which Mep is 2-mercaptopropionyl and A and B are glutamine (Gln) or asparagine (Asn) and A is Gln only when B is Gln.
Claim 3
Dependent Claim
15 words
Vasopressin derivative as recited in claim 1, wherein A is Asn and B is Asn.
Claim 4
Dependent Claim
15 words
Vasopressin derivative as recited in claim 1, wherein A is Asn and B is Gln.
Claim 5
Dependent Claim
15 words
Vasopressin derivative as recited in claim 1, wherein A is Gln and B is Gln.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-09 | 1982-10-09 | 1983-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-09 | 1986-10-09 | 1987-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-09 | 1990-10-09 | 1991-04-10 | $7700.00 | Window Closed / Lapsed |