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US4397868A
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Method of treating atherosclerosis with trisubstituted ureas
Assignee: Wyeth Holdings LLC
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Filing: 1982-01-26
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Granted: 1983-08-09
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Expires: 2002-01-26
Abstract
Abstract Methods of treating atherosclerosis with trisubstituted ureas, compositions thereof and processes for their preparation.
Inventors
- 👤 Vern G. DeVries
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 06:03
CPC Classifications
C; C07; C07C; C07C273/00; C07C273/18; C07C273/1809; C07C273/1818; C07C273/1827; A; A61; A61K; A61K31/00; A61K31/16; A61K31/17
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
143 words
A method of treating atherosclerosis, reducing the cholesterol ester content of the arterial wall, inhibiting atherosclerotic lesion development and/or treating hyperlipidemia in a mammal in need of such treatment which comprises administering to said mammal an effective amount of a compound of the formula: ##STR5## wherein R 1 and R 2 are different and are independently selected from the group consisting of C 4 -C 12 alkyl, C 4 -C 12 alkenyl, C 4 -C 12 alkynyl, C 4 -C 12 cycloalkyl, C 4 -C 12 cycloalkylalkyl, C 7 -C 14 aralkyl, and C 7 -C 14 aralkyl in which an aromatic ring bears at least one substituent selected from the group consisting of C 1 -C 10 alkyl, C 1 -C 10 alkoxy, phenoxy, benzyloxy, methylenedioxy, C 1 -C 4 alkylthio, phenyl, halo, trihalomethyl, adamantyl, C 1 -C 4 carboalkoxy, and nitro.
Claim 2
Independent Claim
143 words
A method of treating atherosclerosis, reducing the cholesterol ester content of the arterial wall, inhibiting atherosclerotic lesion development and/or treating hyperlipidemia in a mammal in need of such treatment which comprises administering to said mammal an effective amount of a compound of the formula: ##STR5## wherein R 1 and R 2 are different and are independently selected from the group consisting of C 4 -C 12 alkyl, C 4 -C 12 alkenyl, C 4 -C 12 alkynyl, C 4 -C 12 cycloalkyl, C 4 -C 12 cycloalkylalkyl, C 7 -C 14 aralkyl, and C 7 -C 14 aralkyl in which an aromatic ring bears at least one substituent selected from the group consisting of C 1 -C 10 alkyl, C 1 -C 10 alkoxy, phenoxy, benzyloxy, methylenedioxy, C 1 -C 4 alkylthio, phenyl, halo, trihalomethyl, adamantyl, C 1 -C 4 carboalkoxy, and nitro.
Claim 3
Dependent Claim
25 words
A method as recited in claim 1, wherein R 1 is C 7 -C 14 aralkyl and R 2 is C 4 -C 12 alkyl.
Claim 4
Dependent Claim
21 words
A method as recited in claim 2, wherein R 1 is benzyl and R 2 is C 4 -C 12 alkyl.
Claim 5
Dependent Claim
12 words
A method as recited in claim 1, wherein the compound is 1-benzyl-1-(n-butyl)-3-(phenyl)urea.
Claim 6
Dependent Claim
30 words
A method of treating atherosclerosis in a mammal in need of such treatment which comprises administering to said mammal an antiatherosclerotic amount of a compound as recited in claim 1.
Claim 7
Dependent Claim
38 words
A method of reducing the cholesterol ester content of an arterial wall in a mammal in need of such treatment which comprises administering to said mammal a cholesterol ester-reducing amount of a compound as recited in claim 1.
Claim 8
Dependent Claim
34 words
A method of inhibiting atherosclerotic lesion development in a mammal in need of such treatment which comprises administering to said mammal an atherosclerotic lesion development-inhibiting amount of a compound as recited in claim 1.
Claim 9
Dependent Claim
31 words
A method of treating hyperlipidemia in a mammal in need of such treatment which comprises administering to said mammal an effective lipid-altering amount of a compound as recited in claim 1.
References Cited (Backward Citations)
GB1460417A
Cited
US4011340A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-08 | 1987-02-07 | 1987-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-08 | 1991-02-07 | 1991-08-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-08 | 1995-02-07 | 1995-08-09 | $7700.00 | Window Closed / Lapsed |