Patent US4397784A successfully refreshed from Google Patents.
US4397784A
Expired / Lapsed
US
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Inhibitors of transpeptidase
Assignee: Abbott Laboratories
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Filing: 1982-01-04
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Granted: 1983-08-09
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Expires: 2002-01-04
Abstract
Abstract New β-lactams of the general structure: ##STR1## wherein X=O or S; R represents H, loweralkyl, acyl, aryl, or arylloweralkyl; R' is hydrogen, loweralkoxy, loweralkoxyalkyl, loweralkyl, phenylthio or loweralkylmercapto; R" is hydrogen or loweralkyl; and the broken line represents an optional double bond, and certain esters thereof. All compounds are effective antibacterials.
Inventors
- 👤 Daniel T. Chu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 10:43
CPC Classifications
C; C07; C07D; C07D477/00; C07D477/10; C07D477/24; C07D205/00; C07D205/02; C07D205/06; C07D205/08
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
107 words
A compound of the formula ##STR6## wherein X=O or S; R represents H, loweralkyl, phenacetyl, phenoxyacetyl, cyanoacetyl, thenylacetyl, p-sulfophenacetyl, N-benzoylglycylphenylglycyl, a moiety of the formula ##STR7## wherein Y is O or NOR", a mercaptoacetyl of the formula R°SCH 2 CO- wherein R° is phenyl, 4-pyridyl, 2-chloro-2-butenyl, allyl or n-butyl, phenyl, phenylloweralkyl, substituted phenyl or substituted phenylloweralkyl, wherein substituted phenyl is a phenyl moiety substituted with one or more groups independently selected from hydroxy, loweralkoxy, amino, nitro, halo, loweralkyl or phenylloweralkyl; R' is hydrogen, loweralkoxy, loweralkoxyalkyl, loweralkyl, phenylthio or loweralkylmercapto; R" is hydrogen or loweralkyl; and the broken line represents an optional double bond, and acyloxymethyl esters thereof.
Claim 2
Dependent Claim
107 words
A compound of the formula ##STR6## wherein X=O or S; R represents H, loweralkyl, phenacetyl, phenoxyacetyl, cyanoacetyl, thenylacetyl, p-sulfophenacetyl, N-benzoylglycylphenylglycyl, a moiety of the formula ##STR7## wherein Y is O or NOR", a mercaptoacetyl of the formula R°SCH 2 CO- wherein R° is phenyl, 4-pyridyl, 2-chloro-2-butenyl, allyl or n-butyl, phenyl, phenylloweralkyl, substituted phenyl or substituted phenylloweralkyl, wherein substituted phenyl is a phenyl moiety substituted with one or more groups independently selected from hydroxy, loweralkoxy, amino, nitro, halo, loweralkyl or phenylloweralkyl; R' is hydrogen, loweralkoxy, loweralkoxyalkyl, loweralkyl, phenylthio or loweralkylmercapto; R" is hydrogen or loweralkyl; and the broken line represents an optional double bond, and acyloxymethyl esters thereof.
Claim 3
Dependent Claim
10 words
An unsaturated compound of claim 1 wherein R is H.
Claim 4
Dependent Claim
10 words
A compound of claim 2 wherein each R" is methyl.
Claim 5
Dependent Claim
9 words
A compound of claim 3 wherein R' is PhS.
Claim 6
Dependent Claim
9 words
The compound of claim 4 wherein X is O.
Claim 7
Dependent Claim
9 words
The 2-pivaloxymethyl ester of the compound of claim 5.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-08 | 1987-02-07 | 1987-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-08 | 1991-02-07 | 1991-08-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-08 | 1995-02-07 | 1995-08-09 | $7700.00 | Window Closed / Lapsed |