US4396623A
Expired / Lapsed
US
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Carbocyclic analogs of uracil nucleosides as antiviral agents
Assignee: SOUTHERN RESEARCH INSTITUTE A CORP OF AL
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Filing: 1981-08-26
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Granted: 1983-08-02
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Expires: 2001-08-26
Abstract
Abstract There is provided a method for the treatment of viral infections by treating a host animal with a pharmaceutically effective amount of a carbocyclic analog of a nucleoside represented by Formula I: ##STR1## wherein X is chlorine, bromine, iodine, a lower alkyl group or an amino group of the formula --NHR 2 wherein R 2 is a lower alkyl group; and R and R' can be the same or different members selected from the group consisting of hydrogen, an alkanoyl group or an aroyl group.
Inventors
- 👤 Y. Fulmer Shealy
- 👤 C. Allen O'Dell
- 👤 William M. Shannon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 17:46
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/52; C07D239/54; C07D239/545; C07D239/553
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
84 words
A process for the treatment of a host animal having a herpes virus infection which comprises administering to said host animal a therapeutically effective amount of a compound represented by the following formula: ##STR4## wherein X is bromine, iodine, methyl or an amino group of the formula --NHR 2 wherein R 2 is a C 1-4 lower alkyl group; and R and R 1 can be the same or different members selected from the group consisting of hydrogen or a C 1-6 alkanoyl group.
Claim 2
Dependent Claim
84 words
A process for the treatment of a host animal having a herpes virus infection which comprises administering to said host animal a therapeutically effective amount of a compound represented by the following formula: ##STR4## wherein X is bromine, iodine, methyl or an amino group of the formula --NHR 2 wherein R 2 is a C 1-4 lower alkyl group; and R and R 1 can be the same or different members selected from the group consisting of hydrogen or a C 1-6 alkanoyl group.
Claim 3
Dependent Claim
17 words
A process as defined in claim 1 wherein said virus infection is a herpes simplex virus infection.
Claim 4
Dependent Claim
11 words
A process as defined in claim 2 wherein X is Br.
Claim 5
Dependent Claim
18 words
A process as defined in claim 3 wherein each of R and R 1 is CH 3 CO--.
Claim 6
Dependent Claim
16 words
A process as defined in claim 3 wherein each of R and R 1 is hydrogen.
Claim 7
Dependent Claim
11 words
A process as defined in claim 2 wherein X is I.
Claim 8
Dependent Claim
16 words
A process as defined in claim 6 wherein each of R and R 1 is hydrogen.
Claim 9
Dependent Claim
18 words
A process as defined in claim 6 wherein each of R and R 1 is CH 3 CO--.
Claim 10
Dependent Claim
21 words
A process as defined in claim 2 wherein X is --NHCH 3 and each of R and R 1 is hydrogen.
Claim 11
Dependent Claim
23 words
A process as defined in claim 2 wherein X is --NHC 4 H 9 and each of R and R 1 is hydrogen.
Claim 12
Dependent Claim
21 words
A process as defined in claim 2 wherein X is --CH 3 and each of R and R 1 is hydrogen.
Claim 13
Dependent Claim
41 words
A compound having the formula: ##STR5## wherein R 2 is a C 1-4 lower alkyl group, and R and R 1 can be the same or different members selected from the group consisting of hydrogen or a C 1-6 alkanoyl group.
Claim 14
Dependent Claim
41 words
A compound having the formula: ##STR5## wherein R 2 is a C 1-4 lower alkyl group, and R and R 1 can be the same or different members selected from the group consisting of hydrogen or a C 1-6 alkanoyl group.
Claim 15
Dependent Claim
21 words
A compound as defined in claim 12 wherein X is --NHCH 3 and each of R and R 1 is hydrogen.
Claim 16
Dependent Claim
23 words
A compound as defined in claim 12 wherein X is --NHC 4 H 9 and each of R and R 1 is hydrogen.
Claim 17
Dependent Claim
2 words
(±)-5-Bromo-1-[(1α,3.beta.,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-2,4(1H,3H)-pyrimidinedione diacetate.
Claim 18
Dependent Claim
2 words
(±)-5-Bromo-1-[(1α,3.beta.,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-2,4(1H,3H)-pyrimidinedione diacetate.
Claim 19
Dependent Claim
2 words
(±)-1-[(1.alpha.,3β,4α)-3-Hydroxy-4-(hydroxymethyl)cyclopentyl]-5-iodo-2,4(1H,3H)-pyrimidinedione diacetate.
Claim 20
Dependent Claim
2 words
(±)-1-[(1.alpha.,3β,4α)-3-Hydroxy-4-(hydroxymethyl)cyclopentyl]-5-iodo-2,4(1H,3H)-pyrimidinedione diacetate.
References Cited (Backward Citations)
US4177348A
Cited
US4232154A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-01 | 1987-01-31 | 1987-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-01 | 1991-01-31 | 1991-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-01 | 1995-01-31 | 1995-08-02 | $7700.00 | Window Closed / Lapsed |