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US4396615A
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Method of treating androgen-related disorders
Assignee: Duke University
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Filing: 1981-06-24
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Granted: 1983-08-02
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Expires: 2001-06-24
Abstract
Abstract A method of treating androgen-related disorders in an animal which comprises administering to the animal dihydrotestosterone level decreasing amounts of a compound of formula (I): ##STR1## wherein R is H or F; R 1 is selected from the group consisting of --H; straight or branched chain lower alkyl; hydroxyl; --OCOR 3 ; and O--(C 1 -C 6 alkyl); wherein R 3 is --H, C 1 -C 10 straight or branched chain alkyl group, phenyl, phenyl alkylene having straight or branched chain C 1 -C 6 alkylene, C 5 -C 10 cycloalkyl or C 6 -C 10 cycloalkyl alkylene; R 2 is H 2 , methylene, ethylidene, α-CH 3 (H), β-CH 3 (H), α-(OH)(H) or the acetonide derived from the 16α,17α-dihydroxy derivative, and n is 1 or 2.
Inventors
- 👤 Vladimir Petrow
- 👤 Leon Lack
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 08:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/57
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
37 words
A method of treating androgen-related disorders in an animal which comprises administering to said animal dihydrotestosterone level decreasing amounts of a compound of formula (I): ##STR5## wherein R=R 1 =H, R 2 is H 2 and n=1.
Claim 2
Independent Claim
37 words
A method of treating androgen-related disorders in an animal which comprises administering to said animal dihydrotestosterone level decreasing amounts of a compound of formula (I): ##STR5## wherein R=R 1 =H, R 2 is H 2 and n=1.
Claim 3
Dependent Claim
21 words
The method of claim 1 wherein the androgen-related disorder is selected from the group consisting of acne, seborrhea, and androgenic alopecia.
Claim 4
Dependent Claim
22 words
The method of claim 2 wherein the compound is administered as a topical preparation containing from 0.001% to 5% of the compound.
Claim 5
Dependent Claim
27 words
The method of claim 1 wherein the androgen-related disorder is selected from the group consisting of oily skin, hirsutism, benign prostatic hypertrophy and androgen dependent prostatic adenocarcinoma.
Claim 6
Dependent Claim
34 words
The method of claim 4 wherein said disorder is androgen dependent prostatic adenocarcinoma and the compound is administered together with a compound selected from the group consisting of megestrol acetate medrogestone and cyproterone acetate.
Claim 7
Dependent Claim
48 words
A pharmaceutical composition for topical application to the skin of a patient suffering from an androgen-related disorder which comprises 5α-dihydrotestosterone level decreasing amounts of a compound of the formula: ##STR6## wherein R=R 1 =H, R 2 is H 2 and n=1; together with an inert topical pharmaceutical carrier.
Claim 8
Dependent Claim
48 words
A pharmaceutical composition for topical application to the skin of a patient suffering from an androgen-related disorder which comprises 5α-dihydrotestosterone level decreasing amounts of a compound of the formula: ##STR6## wherein R=R 1 =H, R 2 is H 2 and n=1; together with an inert topical pharmaceutical carrier.
Claim 9
Dependent Claim
22 words
The composition of claim 6 wherein said carrier is selected from oleaginous bases, silicones, lanolines, polyethylene glycol, glyceryl monostearate, methylcellulose and hydroxymethylcellulose.
Claim 10
Dependent Claim
30 words
The method of claim 4 wherein the compound is administered orally, by injection, by depot formulation, by implants or silastic implants in an amount of from 0.1 to 50 mg/kg.
References Cited (Backward Citations)
US4055641A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-01 | 1987-01-31 | 1987-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-01 | 1991-01-31 | 1991-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-01 | 1995-01-31 | 1995-08-02 | $7700.00 | Window Closed / Lapsed |