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US4396602A
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Blood glucose level lowering agents
Assignee: Asahi Kasei Corp
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Filing: 1981-09-22
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Granted: 1983-08-02
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Expires: 2001-09-22
Abstract
Abstract A method of lowering the blood glucose level in mammals and a blood glucose level-lowering agent are described. The method comprises administering an enzyme capable of synthesizing sparingly-digestible saccharides from easily-digestible saccharides. The blood glucose level-lowering agent comprises the enzyme capable of synthesizing sparingly-digestible saccharides from easily-digestible saccharides and a glucosidase-inhibiting agent.
Inventors
- 👤 Akira Endo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 05:48
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/45
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
42 words
A method of lowering the blood glucose level in mammals capable of consuming easily-digestible saccharides and which require lowering of blood glucose level, comprising orally administering thereto an effective amount of an enzyme capable of synthesizing sparingly-digestible saccharides from said easily-digestible saccharides.
Claim 2
Independent Claim
42 words
A method of lowering the blood glucose level in mammals capable of consuming easily-digestible saccharides and which require lowering of blood glucose level, comprising orally administering thereto an effective amount of an enzyme capable of synthesizing sparingly-digestible saccharides from said easily-digestible saccharides.
Claim 3
Dependent Claim
16 words
A method as in claim 1, wherein the enzyme is administered together with a glucosidase-inhibiting agent.
Claim 4
Dependent Claim
22 words
A method as in claim 1 or 2, wherein the enzyme synthesizes sparingly-digestible polysaccharides or oligosaccharides from easily-digestible monosaccharides, oligosaccharides, or polysaccharides.
Claim 5
Dependent Claim
22 words
A method as in claim 1 or 2, wherein the enzyme is at least one member selected from dextransucrase and cyclodextrin-synthesizing enzymes.
Claim 6
Dependent Claim
37 words
A method as in claim 4, wherein the dextransucrase is produced by a bacterium selected from the genera Leuconostoc and Streptococcus, and the cyclodextrin-synthesizing enzyme is produced by a bacterium selected from the genera Bacillus and Klebsiella.
Claim 7
Dependent Claim
22 words
A method as in claim 1 or 2, wherein the enzyme is dextransucrase produced by a strain belonging to the genus Streptococcus.
Claim 8
Dependent Claim
24 words
A method as in claim 1 or 2, wherein the enzyme is a cyclodextrin-synthesizing enzyme produced by a strain belonging to the genus Bacillus.
Claim 9
Dependent Claim
20 words
A method as in claim 1, wherein the enzyme is orally administered in an amount of 1 to 100 mg/day.
Claim 10
Dependent Claim
27 words
A method as in claim 2, wherein the mixture of the enzyme and the glucosidase-inhibiting agent is orally administered in an amount of 1 to 100 mg/day.
Claim 11
Dependent Claim
23 words
A blood glucose level-lowering agent comprising effective amounts of an enzyme capable of synthesizing sparingly-digestible saccharides from easily-digestible saccharides and a glucosidase-inhibiting agent.
Claim 12
Dependent Claim
23 words
A blood glucose level-lowering agent comprising effective amounts of an enzyme capable of synthesizing sparingly-digestible saccharides from easily-digestible saccharides and a glucosidase-inhibiting agent.
Claim 13
Dependent Claim
20 words
A blood glucose level-lowering agent as in claim 10, wherein the glucosidase-inhibiting agent inhibits the amylase, sucrase, and maltase actions.
Claim 14
Dependent Claim
25 words
A blood glucose level-lowering agent as in claim 10, wherein the weight ratio of the enzyme to the glucosidase-inhibiting agent is from 1/20 to 20/1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-01 | 1987-01-31 | 1987-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-01 | 1991-01-31 | 1991-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-01 | 1995-01-31 | 1995-08-02 | $7700.00 | Window Closed / Lapsed |