US4393079A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical compositions
Assignee: Beecham Group PLC
•
Filing: 1976-12-15
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Granted: 1983-07-12
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Expires: 1996-12-15
Abstract
Abstract Anti-inflammatory compositions are prepared which comprise a therapeutically effective amount of a compound of the formula ##STR1## wherein X is CO or CHOH; Y is CO; the dotted line represents a double bond which is present or absent; R 1 is hydrogen or methyl; R 2 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxyl, hydroxyl, acetoxyl, nitro or amino; R 3 is alkyl of 3 to 8 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, alkenyl of 3 to 8 carbon atoms, cycloalkenyl of 5 to 8 carbon atoms or phenyl unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, benzyloyl, hydroxyl, acetoxyl, trifluoromethyl, nitro, amino, acetyl, methylthiol, methylsulphonyl, methylamino and dimethylamino. Compounds of formula I above are also novel.
Inventors
- 👤 William G. Cole
- 👤 Alexander C. Goudie
- 👤 Carl J. Rose
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 13:27
CPC Classifications
C; C07; C07C; C07C49/00; C07C49/76; C07C49/84; C07C205/00; C07C205/45; C07C29/00; C07C29/132; C07C29/136; C07C29/143; C07C45/00; C07C45/45; C07C45/46; C07C45/61; C07C45/62; C07C45/64; C07C45/67; C07C45/68; C07C45/70; C07C45/71; C07C49/20; C07C49/213; C07C49/215; C07C49/217; C07C49/223; C07C49/225; C07C49/227; C07C49/233; C07C49/235; C07C49/24; C07C49/245; C07C49/248; C07C49/255; C07C49/782; C07C49/792; C07C49/794; C07C49/80; C07C49/813; C07C49/82; C07C49/83
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
104 words
A pharmaceutical composition useful for the treatment of inflammation in humans and animals which comprises an anti-inflammatory amount of a compound of the formula ##STR16## wherein X is CO or CHOH; Y is CO; the dotted line represents a double bond which is present or absent; R 1 is hydrogen or methyl; R 2 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxyl, hydroxyl or nitro; and R 3 is phenyl unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, hydroxyl, trifluoromethyl, nitro, methylthio or methylsulphonyl; in combination with a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
104 words
A pharmaceutical composition useful for the treatment of inflammation in humans and animals which comprises an anti-inflammatory amount of a compound of the formula ##STR16## wherein X is CO or CHOH; Y is CO; the dotted line represents a double bond which is present or absent; R 1 is hydrogen or methyl; R 2 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxyl, hydroxyl or nitro; and R 3 is phenyl unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, hydroxyl, trifluoromethyl, nitro, methylthio or methylsulphonyl; in combination with a pharmaceutically acceptable carrier.
Claim 3
Independent Claim
109 words
A method of treating inflammation in humans and animals which comprises administering to a human or animal in need thereof an anti-inflammatory amount of a compound of the formula ##STR17## wherein X is CO or CHOH; Y is CO; the dotted line represents a double bond which is present or absent; R 1 is hydrogen or methyl; R 2 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxyl, hydroxyl or nitro; and R 3 is phenyl unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, hydroxyl, trifluoromethyl, nitro, methylthio or methylsulphonyl; in combination with a pharmaceutically acceptable carrier.
Claim 4
Independent Claim
109 words
A method of treating inflammation in humans and animals which comprises administering to a human or animal in need thereof an anti-inflammatory amount of a compound of the formula ##STR17## wherein X is CO or CHOH; Y is CO; the dotted line represents a double bond which is present or absent; R 1 is hydrogen or methyl; R 2 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxyl, hydroxyl or nitro; and R 3 is phenyl unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, hydroxyl, trifluoromethyl, nitro, methylthio or methylsulphonyl; in combination with a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
64 words
A composition according to claim 1 wherein the compound is of the formula ##STR18## wherein X is CO or CHOH; Y is CO; the dotted line represents a double bond which is present or absent; R 1 is hydrogen or methyl; R 4 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl or methoxyl; and R 5 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl or methoxyl.
Claim 6
Dependent Claim
22 words
A composition according to claim 3 wherein Y is attached to the R 4 substituted phenyl ring in the 3- or 4-position.
Claim 7
Dependent Claim
22 words
A composition according to claim 4 wherein R 4 is hydrogen, fluorine or chlorine and R 5 is hydrogen, fluorine or chlorine.
Claim 8
Dependent Claim
34 words
A composition according to claim 1 wherein the compound is of the formula ##STR19## wherein X is CO or CHOH; R 1 is hydrogen or methyl and R 8 is hydrogen, fluorine or chlorine.
Claim 9
Dependent Claim
11 words
A composition according to claim 6 wherein the compound is 4-benzoyl-phenyl-2-pentanone.
Claim 10
Dependent Claim
10 words
A composition according to claim 6 in oral administration form.
Claim 11
Dependent Claim
64 words
A method according to claim 2 wherein the compound is of the formula ##STR20## wherein X is CO or CHOH; Y is CO; the dotted line represents a double bond which is present or absent; R 1 is hydrogen or methyl; R 4 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl or methoxyl; and R 5 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl or methoxyl.
Claim 12
Dependent Claim
22 words
A method according to claim 9 wherein Y is attached to the R 4 substituted phenyl ring in the 3- or 4-position.
Claim 13
Dependent Claim
22 words
A method according to claim 10 wherein R 4 is hydrogen, fluorine or chlorine and R 5 is hydrogen, fluorine or chlorine.
Claim 14
Dependent Claim
34 words
A method according to claim 2 wherein the compound is of the formula ##STR21## wherein X is CO or CHOH; R 1 is hydrogen or methyl and R 8 is hydrogen, fluorine or chlorine.
Claim 15
Dependent Claim
11 words
A method according to claim 12 wherein the compound is 4-benzoyl-phenyl-2-pentanone.
Claim 16
Dependent Claim
11 words
A method according to claim 12 wherein the administration is oral.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-07-11 | 1987-01-10 | 1987-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-07-11 | 1991-01-10 | 1991-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-07-11 | 1995-01-10 | 1995-07-12 | $7700.00 | Window Closed / Lapsed |