US4393077A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Methylene-1-phenylguanidine compounds
Assignee: William H Rorer Inc
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Filing: 1981-07-02
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Granted: 1983-07-12
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Expires: 2001-07-02
Abstract
Abstract Compounds having the formula: ##STR1## wherein X 1 , X 2 , R, R 1 , R 2 and R 3 are as set forth hereinafter, their preparation and uses as ganglionic blocking agents are disclosed.
Inventors
- 👤 George H. Douglas
- 👤 Henry F. Campbell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:37
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/155
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
125 words
A method for ganglionic blocking which comprises administering an effective amount of a compound of the formula ##STR4## and the pharmaceutically acceptable salts thereof, wherein X 1 and X 2 each represent a member selected from the group consisting of hydrogen, halo, trifluoromethyl, acyl, alkyl, hydroxy, alkoxy and amino, R 1 , R 2 , and R 3 each represent a member selected from the group consisting of hydrogen, lower alkyl and lower alkenyl and R represents a member selected from the group consisting of cycloalkyl, cycloalkenyl and aryl, also, R 3 and either R 1 or R 2 can constitute a methylene bridge, --(CH 2 ) 2 -- or --(CH 2 ) 3 --, resulting in the formation of a five- or six-membered ring.
Claim 2
Independent Claim
125 words
A method for ganglionic blocking which comprises administering an effective amount of a compound of the formula ##STR4## and the pharmaceutically acceptable salts thereof, wherein X 1 and X 2 each represent a member selected from the group consisting of hydrogen, halo, trifluoromethyl, acyl, alkyl, hydroxy, alkoxy and amino, R 1 , R 2 , and R 3 each represent a member selected from the group consisting of hydrogen, lower alkyl and lower alkenyl and R represents a member selected from the group consisting of cycloalkyl, cycloalkenyl and aryl, also, R 3 and either R 1 or R 2 can constitute a methylene bridge, --(CH 2 ) 2 -- or --(CH 2 ) 3 --, resulting in the formation of a five- or six-membered ring.
Claim 3
Dependent Claim
12 words
The method according to claim 1, wherein the compound is 1-cyclopropylmethyl-1-(2,6-dichlorophenyl) guanidine.
Claim 4
Dependent Claim
12 words
The method according to claim 1, wherein the compound is 1-cyclobutylmethyl-1-(2,6-dichlorophenyl) guanidine.
Claim 5
Dependent Claim
12 words
The method according to claim 1, wherein the compound is 1-cyclohexylmethyl-1-(2,6-dichlorophenyl) guanidine.
References Cited (Backward Citations)
US3914306A
Cited
US4277487A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-07-11 | 1987-01-10 | 1987-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-07-11 | 1991-01-10 | 1991-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-07-11 | 1995-01-10 | 1995-07-12 | $7700.00 | Window Closed / Lapsed |