US4277487A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted 2-phenylamino-2-imidazolines as bradycardiacs
Assignee: Boehringer Ingelheim GmbH
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Filing: 1979-07-17
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Granted: 1981-07-07
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Expires: 1999-07-17
Abstract
Abstract Compounds of the formula <IMAGE> wherein R1 and R2, which may be the same or different, represent a hydrogen atom, a chlorine atom, or a methyl group, with the proviso that not both R1 and R2 are hydrogen, and R represents a radical selected from the group consisting of -(CH2)2 -C(CH3)=CH2, -(CH2)2-CH=CH2, -O-CH2-CH=CH2, -O-(CH2)2-CH=CH2, -O-CH2-C(CH3)=CH2, -O-CH2-CH=CH-CH3, <IMAGE> <IMAGE> +TR <IMAGE> and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.
Inventors
- 👤 Helmut Stahle
- 👤 Herbert Koppe
- 👤 Werner Kummer
- 👤 Walter Kobinger
- 👤 Christian Lillie
- 👤 Ludwig Pichler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:06
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/04; C07D233/28; C07D233/44; C07D233/50; A; A61; A61P; A61P9/00; A61P9/14
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
105 words
A compound of the formula ##STR19## wherein R 1 and R 2 , which may be the same or different, represent a hydrogen atom, a chlorine atom, or a methyl group, with the proviso that not both R 1 and R 2 are hydrogen, and R represents a radical selected from the group consisting of --(CH 2 ) 2 --C(CH 3 )═CH 2 , --(CH 2 ) 2 --CH═CH 2 , --O--CH 2 --CH═CH 2 , --O--(CH 2 ) 2 --CH═CH 2 , --O--CH 2 --C(CH 3 )═CH 2 , --O--CH 2 --CH═CH--CH 3 , ##STR20## or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
105 words
A compound of the formula ##STR19## wherein R 1 and R 2 , which may be the same or different, represent a hydrogen atom, a chlorine atom, or a methyl group, with the proviso that not both R 1 and R 2 are hydrogen, and R represents a radical selected from the group consisting of --(CH 2 ) 2 --C(CH 3 )═CH 2 , --(CH 2 ) 2 --CH═CH 2 , --O--CH 2 --CH═CH 2 , --O--(CH 2 ) 2 --CH═CH 2 , --O--CH 2 --C(CH 3 )═CH 2 , --O--CH 2 --CH═CH--CH 3 , ##STR20## or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
24 words
A bradycardiac pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective bradycardiac amount of a compound of claim 1.
Claim 4
Dependent Claim
33 words
The method of slowing the heart rate of a warm-blooded animal in need thereof, which comprises perorally or parenterally administering to said animal an effective bradycardiac amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-06 | 1985-01-05 | 1985-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-06 | 1989-01-05 | 1989-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-06 | 1993-01-05 | 1993-07-07 | $7700.00 | Window Closed / Lapsed |