US4390499A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chemical analysis system including a test package and rotor combination
Assignee: International Business Machines Corp
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Filing: 1981-08-13
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Granted: 1983-06-28
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Expires: 2001-08-13
Abstract
Abstract Apparatus for carrying out in situ chemical analysis of biological fluids is disclosed. A test package adapted for use with spinning rotor includes a sample-compartment, an integral cuvette and compartments for prepackaged reagents. The latter are adapted to be introduced via breakable seals into the sample compartment which contains the sample to be analyzed. The sample and reagents are then introduced via another breakable seal into a cuvette. Under pneumatic and rotational forces, mixing and measuring are carried out in situ. The rotor includes a programmable pressure applying arrangement whereby the dispensing of reagents and the movement of the latter and sample into a cuvette are controlled. Optical measurements are then carried out in situ.
Inventors
- 👤 Huntington W. Curtis
- 👤 Robert M. Kellogg
- 👤 Kerry W. Kissinger
- 👤 Robert P. Mappes
- 👤 Emery J. Stephans
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:37
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/01; G01N21/03; G01N21/07; G01N35/00; G01N35/02; G01N35/04; G01N2035/0401; G01N2035/0429; G01N2035/0436
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
101 words
Chemical analysis apparatus comprising in combination a rotor having means adapted to support at least one test package therewithin, at least one test package receivable in said rotor comprising: a flexible sample compartment for receiving a biological fluid sample therein, at least one flexible reagent storage compartment disposed in breakable, sealed relationship with said sample compartment, a flexible cuvette disposed in breakable, sealed relationship with said reagent storage compartment, said flexible cuvette being positioned outermost in said rotor, and, means integral with said rotor for rupturing the breakable, sealed relationship between said sample compartment, said reagent storage compartment and said cuvette.
Claim 2
Dependent Claim
101 words
Chemical analysis apparatus comprising in combination a rotor having means adapted to support at least one test package therewithin, at least one test package receivable in said rotor comprising: a flexible sample compartment for receiving a biological fluid sample therein, at least one flexible reagent storage compartment disposed in breakable, sealed relationship with said sample compartment, a flexible cuvette disposed in breakable, sealed relationship with said reagent storage compartment, said flexible cuvette being positioned outermost in said rotor, and, means integral with said rotor for rupturing the breakable, sealed relationship between said sample compartment, said reagent storage compartment and said cuvette.
Claim 3
Dependent Claim
18 words
Chemical analysis apparatus according to claim 1 further including means connected to said rotor for spinning said rotor.
Claim 4
Dependent Claim
43 words
Chemical analysis apparatus according to claim 1 wherein said at least one test package further includes a transparent element to which said sample compartment, said at least a reagent storage compartment and said cuvette are attached by means of breakable and unbreakable seals.
Claim 5
Dependent Claim
36 words
Chemical analysis apparatus according to claim 1 wherein said at least one flexible reagent storage compartment further includes at least one subcompartment disposed in breakable, sealed relationship within said at least one flexible reagent storage compartment.
Claim 6
Dependent Claim
24 words
Chemical analysis apparatus according to claim 1 further including means disposed in juxtaposition with said cuvette for sensing an optical characteristic of said sample.
Claim 7
Dependent Claim
27 words
Chemical analysis apparatus according to claim 5 wherein said means for sensing includes a quartz window disposed in said rotor positioned in registry with said flexible cuvette.
Claim 8
Dependent Claim
62 words
Chemical analysis apparatus according to claim 1 wherein said means for rupturing includes pneumatically actuated barriers disposed in said rotor and positioned between said sample compartment and said at least one flexible reagent storage compartment and, between the latter and said cuvette, and a pneumatically actuated diaphragm disposed in said rotor positioned adjacent to said at least one flexible reagent storage compartment.
Claim 9
Dependent Claim
28 words
Chemical analysis apparatus according to claim 7 further including pneumatic means connected to said barriers and said diaphragm for actuating said barriers and said diaphragm separately or simultaneously.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-06-27 | 1986-12-27 | 1987-06-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-06-27 | 1990-12-27 | 1991-06-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-06-27 | 1994-12-27 | 1995-06-28 | $7700.00 | Window Closed / Lapsed |