Hydroxypropyl-triazole compounds, their production and their medicinal use

Claim 2

A hydroxypropyltriazole of the formula ##STR97## or a salt thereof, in which Az denotes a 1,2,4-triazol-1-yl or 1,3,4-triazol-1-yl radical, R denotes phenyl, naphthyl or tetrahydronaphthyl radical which is unsubstituted or substituted by halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy or halogenoalkyl with 1 to 4 carbon atoms and up to 5 halogen atoms, R 1 denotes a phenyl or C 3 -C 7 cycloalkyl radical which is unsubstituted or substituted by halogen or C 1 -C 4 -alkyl and R 2 denotes a hydrogen atom, or R 1 and R 2 together, in the o-position relative to one another, represent an optionally halogen or C 1 -C 4 -alkyl substituted methylene bridge with 3 to 5 methylene groups, or, together with the phenyl ring, represent naphthyl, R 3 represents halogen, an alkyl or alkoxy group with in each case 1 to 4 carbon atoms or halogenoalkyl with 1 to 4 carbon atoms and up to 5 halogen atoms and n is 0, 1, 2 or 3.

Claim 3

A compound according to claim 1 in which Az denotes a 1,2,4-triazol-1-yl or 1,3,4-triazol-1-yl radical, R denotes a phenyl, naphthyl radical or tetrahydronaphthyl radical which is unsubstituted or substituted by halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy or halogenoalkyl with 1 to 4 carbon atoms and up to 5 halogen atoms, R 1 denotes a phenyl or C 3 to C 7 cycloalkyl radical and R 2 denotes a hydrogen atom, or R 1 and R 2 together, in the ortho-position relative to one another, denote a methylene bridge which has 3 to 5 methylene groups and is optionally monosubstituted or polysubstituted by halogen or C 1 -C 4 -alkyl, or R 1 and R 2 , together with the phenyl ring, complete a naphthyl radical; R 3 denotes a halogen atom, a straight-chain or branched alkyl or alkoxy group with in each case 1 to 4 carbon atoms, or a halogenoalkyl group with 1 to 4 carbon atoms and up to 5 halogen atoms, and n is 0, 1 or 2.

Claim 4

A compound according to claim 1 in which Az denotes a 1,2,4-triazol-1-yl or a 1,3,4-triazol-1-yl radical R denotes a phenyl radical which is optionally monosubstituted or disubstituted by chlorine, fluorine or methyl, or denotes a naphthyl or tetrahydronaphthyl radical, R 1 denotes a phenyl, cyclopentyl or cyclohexyl radical, which is optionally monosubstituted or disubstituted by chlorine, bromine, fluorine or methyl, and R 2 denotes a hydrogen atom, or R 1 and R 2 together, in the ortho-position relative to one another, denote a trimethylene, tetramethylene or pentamethylene bridge which is optionally substituted by chlorine or methyl or together with the phenyl ring, complete a naphthyl radical; R 3 denotes a chlorine or fluorine atom or a methyl group; and n is 0 or 1.

Claim 5

The compound of the formula ##STR98##

Claim 6

The compound of the formula ##STR98##

Claim 7

The compound of the formula ##STR99##

Claim 8

The compound of the formula ##STR99##

Claim 9

The compound of the formula ##STR100##

Claim 10

The compound of the formula ##STR100##

Claim 11

The compound of the formula ##STR101##

Claim 12

The compound of the formula ##STR101##

Claim 13

The compound of the formula ##STR102##

Claim 14

The compound of the formula ##STR102##

Claim 15

A pharmaceutical composition containing as an active ingredient an antimycotically effective amount of a compound according to claim 1 in admixture with a diluent.

Claim 16

A pharmaceutical composition of claim 9 in the form of a sterile or physiologically isotonic aqueous solution.

Claim 17

A composition according to claim 9 or 10 containing from 0.5 to 95% by weight of the said active ingredient.

Claim 18

A medicament in dosage unit form comprising an antimycotically effective amount of a compound according to claim 1 and an inert pharmaceutical carrier.

Claim 19

A medicament of claim 12 in the form of tablets, pills, dragees, capsules, ampoules, or suppositories.

Claim 20

A method of combating mycoses in warm-blooded animals which comprises administering to the animals an antimycotically effective amount of an active compound according to claim 1 either alone or in admixture with a diluent or in the form of a medicament.

Claim 21

A method according to claim 14 in which the active compound is administered in an amount of 50 to 200 mg per kg body weight per day.

Claim 22

A method according to claim 14 or 15 in which the active compound is administered parenterally.