Patent US4379086A successfully refreshed from Google Patents.
US4379086A
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Method of preparing immunoglobulin suitable for intravenous administration using PEG
Assignee: Fujirebio Inc
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Filing: 1982-05-28
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Granted: 1983-04-05
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Expires: 2002-05-28
Abstract
Abstract The method of preparing immunoglobulin (IgG) suitable for intravenous administration comprising the fractionation of Cohn Plasma Fraction II with polyethylene glycol having a molecular weight of 4000 at predetermined concentrations and under selected pH conditions.
Inventors
- 👤 Tokusuke Kimura
- 👤 Fumio Kurosu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 09:14
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/06; C07K16/065; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83; Y10S530/831
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
103 words
The method of preparing immunoglobulin suitable for intravenous administration which comprises the steps of: (1) dissolving Cohn Plasma Fraction II in a Phosphate buffer solution having a pH of 7.0 to 8.0 to a concentration of 2% to 3%, (2) adding polyethylene glycol (PEG) having a molecular weight of 4000 to the solution to a concentration of 3% to 4%, (3) removing aggregates of immunoglobulin produced and precipitated by centrifugation, (4) adding PEG (M.W. 4000) to the supernatant to a concentration of 6% to 8% at a pH of 6.5 to 7.0, and (5) separating immunoglobulin as a paste from the aqueous liquid.
Claim 2
Independent Claim
103 words
The method of preparing immunoglobulin suitable for intravenous administration which comprises the steps of: (1) dissolving Cohn Plasma Fraction II in a Phosphate buffer solution having a pH of 7.0 to 8.0 to a concentration of 2% to 3%, (2) adding polyethylene glycol (PEG) having a molecular weight of 4000 to the solution to a concentration of 3% to 4%, (3) removing aggregates of immunoglobulin produced and precipitated by centrifugation, (4) adding PEG (M.W. 4000) to the supernatant to a concentration of 6% to 8% at a pH of 6.5 to 7.0, and (5) separating immunoglobulin as a paste from the aqueous liquid.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-04-04 | 1986-10-04 | 1987-04-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-04-04 | 1990-10-04 | 1991-04-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-04-04 | 1994-10-04 | 1995-04-05 | $7700.00 | Window Closed / Lapsed |