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US4373097A
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Process for preparing adenosine derivatives of anti-inflammatory and analgesic activity
Assignee: Bioresearch SRL
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Filing: 1981-04-27
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Granted: 1983-02-08
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Expires: 2001-04-27
Abstract
Abstract Therapeutic composition of antiinflammatory, analgesic and antipyretic activity comprising as its active principle at least one component of general formula: ##STR1## in which: R is a linear or branched alkyl radical of 1-18 C atoms, or phenylalkylene in which the alkylene chain has 1-6 C atoms R 1 is H, an aliphatic acyl radical of 1-6 C atoms or an aromatic acyl radical R 2 is H, an aliphatic acyl radical of 1-6 C atoms, or an aromatic acyl radical, or alternatively the radicals R 2 together form an isopropylidene chain n is 0 or 1.
Inventors
- 👤 Giorgio Stramentinoli
- 👤 Federico Gennari
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 15:24
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
30 words
A process for preparing 5'-deoxy-5'-methylthioadenosine, wherein S-adenosyl-methionine, in concentrated aqueous solution, is hydrolysed by heating under reflux, and the 5'-deoxy-5'-methylthioadenosine formed is separated by cooling after neutralising the reaction mixture.
Claim 2
Dependent Claim
30 words
A process for preparing 5'-deoxy-5'-methylthioadenosine, wherein S-adenosyl-methionine, in concentrated aqueous solution, is hydrolysed by heating under reflux, and the 5'-deoxy-5'-methylthioadenosine formed is separated by cooling after neutralising the reaction mixture.
Claim 3
Dependent Claim
22 words
A process as claimed in claim 1, wherein the aqueous solution of S-adenosyl-methionine is concentrated by heating under vacuum to 35°-40° C.
Claim 4
Dependent Claim
18 words
A process as claimed in claim 1, wherein the 5'-deoxy-5'-methylthioadenosine formed is precipitated by cooling to 0°-5° C.
References Cited (Backward Citations)
US3212954A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-02-07 | 1986-08-09 | 1987-02-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-02-07 | 1990-08-09 | 1991-02-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-02-07 | 1994-08-09 | 1995-02-08 | $7700.00 | Window Closed / Lapsed |