US4371686A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antithrombogenic, highly elastic polyurethane compound
Assignee: National Institute of Advanced Industrial Science and Technology
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Filing: 1981-09-14
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Granted: 1983-02-01
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Expires: 2001-09-14
Abstract
Abstract An antithrombogenic, highly elastic polyurethane compound produced by the reaction of a polyether diol with a diisocyanate and a diamine, which polyurethane compound is characterized by said polyether diol being a compound of the general formula: <IMAGE> wherein, a, b, and c each denote a positive integer and having a polyoxyethlene content in the range of from 10 to 50 weight percent and an average molecular weight in the range of from 500 to 5,000.
Inventors
- 👤 Noboru Yamamoto
- 👤 Iwao Yamashita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:38
CPC Classifications
C; C08; C08G; C08G18/00; C08G18/06; C08G18/28; C08G18/40; C08G18/48; C08G18/4833; C08G18/4837; C08G18/4841; A; A61; A61L; A61L27/00; A61L27/14; A61L27/18; A61L33/00; A61L33/06; A61L33/068; C08G18/08; C08G18/10; Y; Y10; Y10S; Y10S528/00; Y10S528/904
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
99 words
An antithrombogenic, highly elastic, uncrosslinked polyurethane compound produced by the reaction of a polyether diol of the general formula: ##STR6## wherein, a, b, and c each denote a positive integer, having a polyoxyethylene content in the range of from 10 to 50 weight percent and an average molecular weight in the range of from 500 to 5,000, with 1.5 to 4 mols of a diisocyanate per mol of said polyether diol to give a prepolymer followed by reacting said prepolymer with 0.5 to 3 mols of a diamine per mol of said polyether diol to give said uncrosslinked polyurethane.
Claim 2
Dependent Claim
99 words
An antithrombogenic, highly elastic, uncrosslinked polyurethane compound produced by the reaction of a polyether diol of the general formula: ##STR6## wherein, a, b, and c each denote a positive integer, having a polyoxyethylene content in the range of from 10 to 50 weight percent and an average molecular weight in the range of from 500 to 5,000, with 1.5 to 4 mols of a diisocyanate per mol of said polyether diol to give a prepolymer followed by reacting said prepolymer with 0.5 to 3 mols of a diamine per mol of said polyether diol to give said uncrosslinked polyurethane.
Claim 3
Dependent Claim
39 words
The antithrombogenic polyurethane compound according to claim 1, wherein said polyether diol has a polyoxyethylene content in the range of from 10 to 40 weight percent and an average molecular weight in the range of from 1,000 to 3,000.
Claim 4
Dependent Claim
24 words
The antithrombogenic polyurethane compound according to claim 1, wherein said compound has a tensile strength at break of at least 120 kg/cm 2 .
Claim 5
Dependent Claim
24 words
The antithrombogenic polyurethane compound according to claim 1, wherein said compound has a 100% modulus of elasticity of at least 28 kg/cm 2 .
Claim 6
Dependent Claim
20 words
The antithrombogenic polyurethane compound according to claim 1, wherein said compound has an elongation at break of at least 1100%.
Claim 7
Independent Claim
116 words
A method for the manufacture of an antithrombogenic device exposed to contact with blood, which comprises molding an antithrombogenic, highly elastic, uncrosslinked polyurethane compound produced by the reaction of a polyether diol of the general formula: ##STR7## wherein, a, b, and c each denote a positive integer, having a polyoxyethylene content in the range of from 10 to 50 weight percent and an average molecular weight in the range of from 500 to 5,000, with 1.5 to 4 mols of a diisocyanate per mol of said polyether diol to give a prepolymer followed by reacting said prepolymer with 0.5 to 3 mols of a diamine per mol of said polyether diol to give said uncrosslinked polyurethane.
Claim 8
Independent Claim
116 words
A method for the manufacture of an antithrombogenic device exposed to contact with blood, which comprises molding an antithrombogenic, highly elastic, uncrosslinked polyurethane compound produced by the reaction of a polyether diol of the general formula: ##STR7## wherein, a, b, and c each denote a positive integer, having a polyoxyethylene content in the range of from 10 to 50 weight percent and an average molecular weight in the range of from 500 to 5,000, with 1.5 to 4 mols of a diisocyanate per mol of said polyether diol to give a prepolymer followed by reacting said prepolymer with 0.5 to 3 mols of a diamine per mol of said polyether diol to give said uncrosslinked polyurethane.
Claim 9
Dependent Claim
32 words
The method according to claim 6, wherein said polyether diol contains 10 to 30 weight percent of polyoxyethylene and has an average molecular weight in the range of from 1,000 to 3,000.
Claim 10
Independent Claim
136 words
A method for the manufacture of an antithrombogenic film to be deposited as a coating on the surface of a device, which comprises dissolving in a solvent an antithrombogenic, highly elastic, uncrosslinked polyurethane compound produced by the reaction of a polyether diol of the general formula: ##STR8## wherein, a, b, and c each denote a positive integer, having a polyoxyethylene content in the range of from 10 to 50 weight percent and an average molecular weight in the range of from 500 to 5,000, with 1.5 to 4 mols of a diisocyanate per mol of said polyether diol to give a prepolymer followed by reacting said prepolymer with 0.5 to 3 mols of a diamine per mol of said polyether diol to give uncrosslinked polyurethane, and applying the resultant solution to the surface of a device.
Claim 11
Independent Claim
136 words
A method for the manufacture of an antithrombogenic film to be deposited as a coating on the surface of a device, which comprises dissolving in a solvent an antithrombogenic, highly elastic, uncrosslinked polyurethane compound produced by the reaction of a polyether diol of the general formula: ##STR8## wherein, a, b, and c each denote a positive integer, having a polyoxyethylene content in the range of from 10 to 50 weight percent and an average molecular weight in the range of from 500 to 5,000, with 1.5 to 4 mols of a diisocyanate per mol of said polyether diol to give a prepolymer followed by reacting said prepolymer with 0.5 to 3 mols of a diamine per mol of said polyether diol to give uncrosslinked polyurethane, and applying the resultant solution to the surface of a device.
Claim 12
Dependent Claim
32 words
The method according to claim 8, wherein said polyether diol contains 10 to 30 weight percent of polyoxyethylene and has an average molecular weight in the range of from 1,000 to 3,000.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-31 | 1986-08-02 | 1987-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-31 | 1990-08-02 | 1991-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-31 | 1994-08-02 | 1995-02-01 | $7700.00 | Window Closed / Lapsed |