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US4369256A
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US
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Polyalkylene resins crosslinked with diisocyanate used for selective separation of heparin from other glucosaminoglycanes
Assignee: Crinos Industria Farmacobiologica SpA
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Filing: 1981-04-06
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Granted: 1983-01-18
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Expires: 2001-04-06
Abstract
Abstract A novel polyaminic resin obtained by crosslinking a polyalkyleneamine (in particular polyethyleneamine) with diisocyanates in solution, is useful as a selective separation or extraction agent of a component having a "complementary" chemical structure (particularly heparin), by means of mere contact or "ionic exchange" with aqueous solutions containing it. Heparin is thus even quantitatively extracted from solutions containing it alone or in mixture with other glucosaminoglycanes. The polyamine can then release the "adsorbed" heparin and be recovered by a treatment with saline solutions. The novel resin is used in pharmaco-biological fields.
Inventors
- 👤 Benito Casu
- 👤 Giangiacomo Torri
- 👤 Giorgio Zoppetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 08:14
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; C08G; C08G18/00; C08G18/06; C08G18/28; C08G18/40; C08G18/64; C08G18/6415; C08G18/6423; C08G73/00; C08G73/02; C08G73/0206
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
39 words
An anionic exchange resin for isolating and recovering heparin or another glucosaminoglycane from a solution containing it, wherein said resin is a polyalkylene-imine cross-linked with a diisocyanate in a molar equivalent ratio in the range of 1:0.1 to 1:0.15.
Claim 2
Dependent Claim
39 words
An anionic exchange resin for isolating and recovering heparin or another glucosaminoglycane from a solution containing it, wherein said resin is a polyalkylene-imine cross-linked with a diisocyanate in a molar equivalent ratio in the range of 1:0.1 to 1:0.15.
Claim 3
Dependent Claim
17 words
The resin according to claim 1, wherein said polyalkylene-imine is polyethylene-imine and said diisocyanate is hexamethylene diisocyanate.
Claim 4
Dependent Claim
27 words
The resin according to claim 1 or claim 2, wherein no more than a quarter of the aminic groups of said polyalkylene-imine are reacted with said diisocyanate.
Claim 5
Dependent Claim
27 words
The resin according to claim 1, wherein the structure of said cross-linked polyalkylene-imine is chemically and spatially complementary to the structure of said heparin or other glucosaminoglycane.
References Cited (Backward Citations)
US3325346A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-17 | 1986-07-19 | 1987-01-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-17 | 1990-07-19 | 1991-01-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-17 | 1994-07-19 | 1995-01-18 | $7700.00 | Window Closed / Lapsed |