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Patent US4367238A successfully refreshed from Google Patents.
US4367238A
Expired / Lapsed
US
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Phenyl-alkanoic acid derivative and preparation thereof
Assignee: Astellas Pharma Inc
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Filing: 1981-01-21
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Granted: 1983-01-04
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Expires: 2001-01-21
Abstract
Abstract This invention relates to new phenyl-alkanoic acids, their derivatives at the carboxy group, and pharmaceutically acceptable salts thereof, which have anti-inflammatory, analgesic and antipyretic activities.
Inventors
- 👤 Ikuo Ueda
- 👤 Yoshihiko Kitaura
- 👤 Masaaki Matsuo
- 👤 Nobukiyo Konishi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 07:55
CPC Classifications
C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/06; C07D311/08; C07D311/18; C07C; C07C255/00; C07C317/00; C07C323/00; C07C45/00; C07C45/40; C07C45/61; C07C45/67; C07C45/68; C07C45/70; C07C45/71; C07C47/00; C07C47/52; C07C47/575; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; C07D307/00; C07D307/77; C07D307/78; C07D307/82; C07D307/83; C07D307/86
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
68 words
A compound of the formula: ##STR4## wherein R 1 is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy, R a 3 is C 1-8 alkylene or C 1-8 alkylene substituted with lower alkyl, cyano, amino or protected amino group where the protective group is ar(lower)alkyl, lower alkanoyl, lower alkoxycarbonyl, ar(lower)alkoxycarbonyl, succinoyl or phthaloyl, X is O, S, SO or SO 2 , or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
68 words
A compound of the formula: ##STR4## wherein R 1 is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy, R a 3 is C 1-8 alkylene or C 1-8 alkylene substituted with lower alkyl, cyano, amino or protected amino group where the protective group is ar(lower)alkyl, lower alkanoyl, lower alkoxycarbonyl, ar(lower)alkoxycarbonyl, succinoyl or phthaloyl, X is O, S, SO or SO 2 , or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
35 words
A compound according to claim 1, wherein R 1 is halogen or lower alkyl, R a 3 is C 1-8 alkylene or C 1-8 alkylene substituted with lower alkyl, and X is O or S.
Claim 4
Dependent Claim
18 words
The compound according to claim 2, which is 7-(o-tolyloxy)-2,3-dihydrobenzofuran-2-one, 7-(2-chlorophenoxy)-2,3-dihydrobenzofuran-2-one, 3-methyl-7-(2-chlorophenoxy)-2,3-dihydrobenzofuran-2-one, 3-methyl-7-(o-tolyloxy)-2,3-dihydrobenzofuran-2-one, 3-ethyl-7-(o-tolyloxy)-2,3-dihydrobenzofuran-2-one, 3-methyl-7-(2-fluorophenoxy)-2,3-dihydrobenzofuran-2-one, 7-(2-chlorophenylthio)-2,3-dihydrobenzofuran-2-one, 3-methyl-7-(2-chlorophenylthio)-2,3-dihydrobenzofuran-2-one, or 3-methyl-7-(o-tolylthio)-2,3-dihydrobenzofuran-2-one.
Claim 5
Dependent Claim
35 words
A pharmaceutical composition, comprising an effective amount of a compound of claim 1, as an effective ingredient which possesses antiinflammatory, analgesic and antipyretic properties, in association with a pharmaceutically acceptable, substantially notoxic carrier or excipinet.
Claim 6
Dependent Claim
21 words
A method for treating an inflammation, which comprises: administering an effective amount of the compound of claim 1 to human beings.
Claim 7
Dependent Claim
21 words
A method for treating a headache which comprises: administering an effective amount of the compound of claim 1 to human beings.
Claim 8
Dependent Claim
21 words
A method for treating a toothache which comprises: administering an effective amount of the compound of claim 1 to human beings.
Claim 9
Dependent Claim
20 words
A method for treating pyrexia which comprises: administering an effective amount of the compound of claim 1 to human beings.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-03 | 1986-07-05 | 1987-01-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-03 | 1990-07-05 | 1991-01-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-03 | 1994-07-05 | 1995-01-04 | $7700.00 | Window Closed / Lapsed |