Patent US4364952A successfully refreshed from Google Patents.
US4364952A
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Certain 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylates, composition containing same and method of use
Assignee: Bayer AG
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Filing: 1981-05-29
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Granted: 1982-12-21
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Expires: 2001-05-29
Abstract
Abstract The invention relates to 1,4-dihydropyridines which carry an arylalkyl or aryloxyalkyl radical in the 4-position. Also included in the invention are methods for the preparation of said compounds. The invention further relates to compositions containing said 1,4-dihydropyridines and the use of said compounds and compositions for their circulation influencing effects.
Inventors
- 👤 Carsten Materne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:25
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/90; A; A61; A61P; A61P9/00; A61P9/08; A61P9/10; A61P9/12
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
97 words
A compound which is a 1,4-dihydropyridine of the formula ##STR11## or a salt pharmaceutically acceptable thereof, in which R 1 and R 2 are identical or different and denote a straight-chain or branched alkyl radical with 1 to 4 carbon atoms, R 3 represents a hydrogen atom, a methyl group or a phenyl radical and R 4 represents a phenyl or phenoxy radical unsubstituted, or may optionally carry 1 substituent selected from nitro, halogen, methyl, methoxy or dimethyl, with a proviso that R 3 represents hydrogen or methyl only when R 4 is phenoxy or substituted phenoxy.
Claim 2
Dependent Claim
97 words
A compound which is a 1,4-dihydropyridine of the formula ##STR11## or a salt pharmaceutically acceptable thereof, in which R 1 and R 2 are identical or different and denote a straight-chain or branched alkyl radical with 1 to 4 carbon atoms, R 3 represents a hydrogen atom, a methyl group or a phenyl radical and R 4 represents a phenyl or phenoxy radical unsubstituted, or may optionally carry 1 substituent selected from nitro, halogen, methyl, methoxy or dimethyl, with a proviso that R 3 represents hydrogen or methyl only when R 4 is phenoxy or substituted phenoxy.
Claim 3
Dependent Claim
12 words
A compound according to claim 1 which is 2,6-Dimethyl-4-diphenylmethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester.
Claim 4
Dependent Claim
12 words
A compound according to claim 1 which is 2,6-Dimethyl-4-(2',6'-dimethylphenoxymethyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester.
Claim 5
Dependent Claim
26 words
A pharmaceutical composition containing as an active ingredient a circulation-influencing effective amount of a compound according to claim 1 in admixture with an inert pharmaceutical carrier.
Claim 6
Dependent Claim
18 words
A pharmaceutical composition according to claim 4 in the form of a sterile or physiologically isotonic aqueous solution.
Claim 7
Dependent Claim
20 words
A composition according to claim 4 or 5 containing from 0.5 to 95% by weight of the said active ingredient.
Claim 8
Dependent Claim
24 words
A medicament in dosage unit form comprising a circulation-influencing effective amount of a compound according to claim 1 together with an inert pharmaceutical carrier.
Claim 9
Dependent Claim
16 words
A medicament of claim 7 in the form of tablets, pills, dragees, capsules, ampoules, or suppositories.
Claim 10
Dependent Claim
49 words
A method of lowering blood pressure in warm-blooded animals which comprises administering to the animals in need of such treatment, a blood pressure lowering effective amount of an active compound according to claim 1 either alone or in admixture with a diluent or in the form of a medicament.
References Cited (Backward Citations)
US3485847A
Cited
US4048171A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-12-20 | 1986-06-21 | 1986-12-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-12-20 | 1990-06-21 | 1990-12-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-12-20 | 1994-06-21 | 1994-12-21 | $7700.00 | Window Closed / Lapsed |