Patent JPH04291384A successfully refreshed from Google Patents.
Patent US4361673A successfully refreshed from Google Patents.
US4361673A
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Polypeptide compositions
Assignee: Wyeth LLC
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Filing: 1981-07-27
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Granted: 1982-11-30
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Expires: 2001-07-27
Abstract
Abstract There are disclosed polypeptides having the formula: R1-Lys-Lys-X-R2 wherein R1 is hydrogen or p-Glu; X is Glu or Asp; and R2 is Val, NH2 or Val-NH2; the fully protected peptide-resin intermediates thereof and pharmaceutically acceptable salts thereof. These polypeptides have the capability of inducing the maturation of T-cell populations and thus are useful in a number of therapeutic areas.
Inventors
- 👤 William H. McGregor
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:32
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/107; C07K5/00; C07K5/04; C07K5/10; C07K5/1024; C07K5/08; C07K5/0815; C07K5/1019; C07K7/00; C07K7/04; C07K7/06; C07K7/062; A; A61; A61K; A61K38/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/18; Y10S930/28
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
42 words
A polypeptide having the following formula: R.sub.1 -lys-Lys-X-R.sub.2 wherein R 1 is hydrogen or p-Glu; X is Glu or Asp; and R 2 is Val, NH 2 or Val-NH 2 ; the fully protected peptide-resin intermediates thereof, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
42 words
A polypeptide having the following formula: R.sub.1 -lys-Lys-X-R.sub.2 wherein R 1 is hydrogen or p-Glu; X is Glu or Asp; and R 2 is Val, NH 2 or Val-NH 2 ; the fully protected peptide-resin intermediates thereof, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
15 words
The compound of claim 1, which is p-Glu-Lys-Lys-Glu-Val-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
15 words
The compound of claim 1, which is p-Glu-Lys-Lys-Glu-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
15 words
The compound of claim 1, which is H-Lys-Lys-Glu-Val-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
15 words
The compound of claim 1, which is H-Lys-Lys-Glu-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
15 words
The compound of claim 1, which is H-Lys-Lys-Asp-Val-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
14 words
The compound of claim 1, which is H-Lys-Lys-Glu-Val or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
42 words
A compound of the formula: ##STR2## wherein R 1 is hydrogen or p-Glu; X is Glu or Asp; and R 2 is Val, NH 2 or Val-NH 2 ; A is an amino protecting group; and B is a carboxy protecting group.
Claim 10
Dependent Claim
42 words
A compound of the formula: ##STR2## wherein R 1 is hydrogen or p-Glu; X is Glu or Asp; and R 2 is Val, NH 2 or Val-NH 2 ; A is an amino protecting group; and B is a carboxy protecting group.
Claim 11
Dependent Claim
17 words
The compound of claim 8, having the formula: ##STR3## wherein A is 2-chlorobenzyloxycarbonyl; and B is benzyl.
References Cited (Backward Citations)
US4250086A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-29 | 1986-05-31 | 1986-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-29 | 1990-05-31 | 1990-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-29 | 1994-05-31 | 1994-11-30 | $7700.00 | Window Closed / Lapsed |