US4361652A
Expired / Lapsed
US
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Method for stabilizing plasminogen
Assignee: Tanabe Pharma Corp
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Filing: 1981-01-16
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Granted: 1982-11-30
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Expires: 2001-01-16
Abstract
Abstract A method for stabilizing plasminogen which comprises adding a physiologically acceptable inorganic salt to a plaminogen-containing aqueous solution to give a final concentration of the salt of 0.002 to 0.4 M.
Inventors
- 👤 Yahiro Uemura
- 👤 Katuhiro Uriyu
- 👤 Satoshi Funakoshi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:48
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/6435; C12Y; C12Y304/00; C12Y304/21; C12Y304/21007
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
72 words
In a method for producing a plasminogen preparation comprising adding a physiologically acceptable inorganic salt to a plasminogen-containing aqueous solution to give a final concentration of the salt of 0.002 to 0.4 M and heat-treating the aqueous solution at 60° C. for 10 hours, the improvement which comprises subjecting the aqueous solution to digestion at 4° to 37° C. at pH 2 to 4 for 2 to 60 minutes before the heat-treatment.
Claim 2
Dependent Claim
72 words
In a method for producing a plasminogen preparation comprising adding a physiologically acceptable inorganic salt to a plasminogen-containing aqueous solution to give a final concentration of the salt of 0.002 to 0.4 M and heat-treating the aqueous solution at 60° C. for 10 hours, the improvement which comprises subjecting the aqueous solution to digestion at 4° to 37° C. at pH 2 to 4 for 2 to 60 minutes before the heat-treatment.
Claim 3
Dependent Claim
35 words
A method according to claim 1, wherein said physiologically acceptable inorganic salt is an alkali metal salt, alkali earth metal salt, or ammonium salt of hydrochloric acid, sulfuric acid, boric acid, or of phosphoric acid.
Claim 4
Dependent Claim
58 words
A method according to claim 2, wherein said physiologically acceptable inorganic salt is NaCl, KCl, MgCl 2 , (NH 4 ) 2 ,SO 4 , Na 2 SO 4 , Na 2 B 4 O 7 , KH 2 PO 4 , K 2 HPO 4 , NaH 2 PO 4 , or Na 2 HPO 4 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-29 | 1986-05-31 | 1986-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-29 | 1990-05-31 | 1990-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-29 | 1994-05-31 | 1994-11-30 | $7700.00 | Window Closed / Lapsed |