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US4359468A
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Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones
Assignee: Boehringer Ingelheim Corp
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Filing: 1981-02-25
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Granted: 1982-11-16
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Expires: 2001-02-25
Abstract
Abstract Compounds of the formula <IMAGE> wherein R1 is hydrogen, halogen or methoxy; R2 is hydrogen or lower alkyl; R3 is hydrogen or lower alkyl; R4 is hydrogen, lower alkyl or alkenyl of 3 carbon atoms; and n is 2 to 6; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antiallergics and hypotensives.
Inventors
- 👤 Kurt Freter
- 👤 Victor Fuchs
- 👤 James T. Oliver
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 16:56
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/14; A; A61; A61P; A61P37/00; A61P37/08; A61P43/00; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
51 words
A compound of the formula ##STR15## wherein R 1 is hydrogen, halogen or methoxy; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkyl or lower alkenyl; n is 2 to 6; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
51 words
A compound of the formula ##STR15## wherein R 1 is hydrogen, halogen or methoxy; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkyl or lower alkenyl; n is 2 to 6; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
17 words
A compound of claim 1, which is N-{3-[4-(3-indolyl)-piperidino]-propyl}-benzimidazolone or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
17 words
A compound of claim 1, which is N-{4-[4-(3-indolyl)-piperidino]-butyl}-benzimidazolone or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
22 words
An antiallergic pharmaceutical composition consisting essentially of an inert pharmaceutical carrier and an effective antiallergic amount of a compound of claim 1.
Claim 6
Dependent Claim
35 words
The method of suppressing allergic reactions in a warm-blooded animal in need thereof, which comprises perorally, parenterally, topically or by inhalation administering to said animal an effective antiallergic amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-15 | 1986-05-17 | 1986-11-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-15 | 1990-05-17 | 1990-11-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-15 | 1994-05-17 | 1994-11-16 | $7700.00 | Window Closed / Lapsed |