1,3,4-Triazolo[1,5-a]pyridines

Claim 1

A compound represented by the formula: ##STR13## and the pharmaceutically acceptable salts thereof, wherein R represents hydrogen, lower alkyl of 1-3 carbons, arylalkyl, --CH 2 OH, --CH 2 CN, ##STR14## --NO 2 , --NO, --CH 2 --O--CO--R 1 , (wherein R 1 is lower alkyl or dimethylaminomethyl), --N(R 3 ) 2 (wherein each R 3 independently is hydrogen, lower alkyl of 1-3 carbon atoms or arylalkyl), --S(O) n --CH 3 or --CH 2 --S(O) n --CH 3 wherein n is zero, one or two; X represents hydrogen, lower alkyl, halogen, hydroxy, lower alkoxy, or trifluoromethyl; and Y represents --R 2 , --OR 2 , --NHR 2 , or --S(O) n R 2 wherein n is zero, one or two and R 2 is -lower alkylene-vinyl, -lower alkylene-Ar, -lower alkene-Ar, -lower alkene-lower alkylene-Ar, or -lower alkylene-O-Ar, wherein Ar is substituted-phenyl, phenyl, thienyl, or pyridyl wherein there are one or more substituents on the substituted-phenyl independently selected from --H, --Cl, --F, --CH 3 , -t-butyl, --CF 3 , --OCH 3 and --OH; provided that when --R 2 is lower alkylene-O--Ar, Y is not --OR 2 , --NHR 2 or --S(O) n R 2 .