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US4356181A
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Anti-allergic mono salt of 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]-quinoline-2,8-dicarboxylic acid
Assignee: Fisons Ltd
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Filing: 1981-03-26
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Granted: 1982-10-26
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Expires: 2001-03-26
Abstract
Abstract There is described the mono salt of 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]-quinoline-2,8-dicarboxylic acid with a strongly basic cation. There is also described an aqueous solution of 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid the solution being at a pH of from 4 to 8. The salts and solutions are useful as pharmaceuticals, e.g. in the treatment of allergies.
Inventors
- 👤 David W. Payling
- 👤 John L. Suschitzky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 03:31
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/48; A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K9/00; A61K9/0012; A61K9/007; A61K9/0073; A61K9/0075; A61K9/008; A61P; A61P11/00; A61P37/00; A61P37/08; A61Q; A61Q11/00; C07D491/00; C07D491/02; C07D491/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
13 words
A mono salt of 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]-quinoline-2,8-dicarboxylic acid with a strongly basic pharmaceutically acceptable cation.
Claim 2
Dependent Claim
13 words
A mono salt of 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]-quinoline-2,8-dicarboxylic acid with a strongly basic pharmaceutically acceptable cation.
Claim 3
Dependent Claim
14 words
A salt according to claim 1, wherein the cation is an alkali metal cation.
Claim 4
Dependent Claim
12 words
A salt according to claim 2 which is 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, monosodium salt.
Claim 5
Dependent Claim
21 words
An aqueous solution of a mono salt according to claim 1, the solution having a pH of from 4 to 8.
Claim 6
Dependent Claim
13 words
A solution according to claim 4 having a pH of 4.5 to 7.
Claim 7
Dependent Claim
13 words
A solution according to claim 5 having a pH of 5.0 to 6.5.
Claim 8
Dependent Claim
11 words
A solution according to claim 4 which is a buffered solution.
Claim 9
Dependent Claim
38 words
A pharmaceutical composition useful for treatment of reversible airway obstruction or for prevention of the excretion of excess mucous comprising an effective amount of a salt according to claim 1 and a pharmaceutically acceptable excipient, diluent or carrier.
Claim 10
Dependent Claim
14 words
A composition according to claim 8 in a form suitable for administration by inhalation.
Claim 11
Dependent Claim
23 words
A composition according to claim 8 comprising from 0.001 to 200 mg of a salt according to claim 1 in unit dosage form.
Claim 12
Dependent Claim
42 words
A method of treatment of reversible airway obstruction or of prevention of the excretion of excess mucous which comprises administering an effective amount of a salt according to claim 1 to an individual suffering or liable to suffer from such a condition.
Claim 13
Dependent Claim
42 words
A method of treatment of reversible airway obstruction or of prevention of the excretion of excess mucous which comprises administering an effective amount of a solution according to claim 4 to an individual suffering or liable to suffer from such a condition.
References Cited (Backward Citations)
GB2022078A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-10-25 | 1986-04-26 | 1986-10-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-10-25 | 1990-04-26 | 1990-10-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-10-25 | 1994-04-26 | 1994-10-26 | $7700.00 | Window Closed / Lapsed |