Patent US4350156A successfully refreshed from Google Patents.
US4350156A
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Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid
Assignee: JAPAN FONDATION FOR ARTIFICIAL ORGANS
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Filing: 1980-05-29
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Granted: 1982-09-21
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Expires: 2000-05-29
Abstract
Abstract An on-line filtration system for the removal of macromolecules greater than 70,000 mol. wt. from a physiological solution, such as blood, in the therapeutic treatment of various disease states. For blood, the plasma (which contains the macromolecules) is separated continuously from the blood using a first membrane filter with a membrane porosity of nominally 0.2 to 1.0 micron. The separated plasma is then continuously filtered in a physiological temperature state or a cooled state through a second membrane filter with a membrane porosity of nominally 0.01 to 0.2 micron, which retains the macromolecules. In the cooled state, separation of the macromolecules is effected more efficiently than could be done in the non-cooled state. The treated plasma (macromolecules removed) is then reunited with the blood flow coming from the first plasma filter and returned to the patient. The blood flow and filtration processes are generally continuous. Suitable agent(s) may be added to the separated plasma to promote formation of macromolecules.
Inventors
- 👤 Paul S. Malchesky
- 👤 Yukihiko Nose
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:29
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/34; A61M1/3472; A61M1/3482
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
71 words
A method of removing macromolecules from a plasma solution comprising; providing a plasma solution containing macromolecules including a minimum size thereof, effecting predetermined cooling of said plasma solution to a temperature not lower than just above the freezing point of the plasma solution, and filtering said cooled plasma solution with a membrane filter having a porosity up to said minimum size to remove macromolecules of predetermined size from the plasma solution.
Claim 2
Independent Claim
71 words
A method of removing macromolecules from a plasma solution comprising; providing a plasma solution containing macromolecules including a minimum size thereof, effecting predetermined cooling of said plasma solution to a temperature not lower than just above the freezing point of the plasma solution, and filtering said cooled plasma solution with a membrane filter having a porosity up to said minimum size to remove macromolecules of predetermined size from the plasma solution.
Claim 3
Independent Claim
135 words
A method of removing macromolecules from a physiological solution comprising; securing a physiological solution stream from a patient, separating said physiological solution stream into a concentrated cellular element stream and a plasma stream containing macromolecules including a size above substantially 100,000 daltons therein, filtering macromolecules of a size above substantially 100,000 daltons out of the plasma stream to form a filtered plasma stream substantially free of macromolecules of a size above substantially 100,000 daltons by flow of the plasma stream through a porous medium having openings of a size adapted to pass molecules of a size less than substantially 100,000 daltons and to retain macromolecules of a size above substantially 100,000 daltons, combining said filtered plasma stream and said cellular element stream to form a processed stream, and returning the processed stream to the patient.
Claim 4
Independent Claim
135 words
A method of removing macromolecules from a physiological solution comprising; securing a physiological solution stream from a patient, separating said physiological solution stream into a concentrated cellular element stream and a plasma stream containing macromolecules including a size above substantially 100,000 daltons therein, filtering macromolecules of a size above substantially 100,000 daltons out of the plasma stream to form a filtered plasma stream substantially free of macromolecules of a size above substantially 100,000 daltons by flow of the plasma stream through a porous medium having openings of a size adapted to pass molecules of a size less than substantially 100,000 daltons and to retain macromolecules of a size above substantially 100,000 daltons, combining said filtered plasma stream and said cellular element stream to form a processed stream, and returning the processed stream to the patient.
Claim 5
Dependent Claim
26 words
The method of claim 2 and further including the step of heating the processed stream to approximately body temperature before it is returned to the patient.
Claim 6
Independent Claim
108 words
A method of removing macromolecules from a physiological solution comprising; securing a physiological solution stream from a patient, separating said physiological solution stream into a concentrated cellular element stream and a plasma stream containing macromolecules therein, effecting predetermined cooling of said plasma stream to a temperature of between just above the freezing point of the plasma stream and 35° centigrade, filtering macromolecules of predetermined size out of the cooled plasma stream to form a filtered plasma stream, combining said filtered plasma stream and said cellular element stream to form a processed stream, heating the processed stream to body temperature, and returning the heated processed stream to the patient.
Claim 7
Independent Claim
108 words
A method of removing macromolecules from a physiological solution comprising; securing a physiological solution stream from a patient, separating said physiological solution stream into a concentrated cellular element stream and a plasma stream containing macromolecules therein, effecting predetermined cooling of said plasma stream to a temperature of between just above the freezing point of the plasma stream and 35° centigrade, filtering macromolecules of predetermined size out of the cooled plasma stream to form a filtered plasma stream, combining said filtered plasma stream and said cellular element stream to form a processed stream, heating the processed stream to body temperature, and returning the heated processed stream to the patient.
Claim 8
Dependent Claim
28 words
The method of claim 4 wherein the separation of said physiological solution stream into a concentrated cellular element stream and a plasma stream is effected by a centrifuge.
Claim 9
Dependent Claim
51 words
The method of claim 4 wherein the separation of said physiological solution stream into a concentrated cellular element stream and a plasma stream is effected by a membrane filter, and further including the step of adding a complexing agent to the plasma stream before it is filtered to promote macromolecule formation.
Claim 10
Dependent Claim
11 words
The method of claim 4 wherein said physiological solution is blood.
Claim 11
Dependent Claim
14 words
The method of claim 4 wherein said physiological solution is lymph or ascitic fluid.
Claim 12
Independent Claim
127 words
A method of removing macromolecules from a stream of physiological solution removed directly from a patient including; forming from a stream of a patient's physiological solution a separated stream containing macromolecules including a size above substantially 100,000 daltons and substantially free of red blood cells, then using a membrane filter having a porosity to remove macromolecules of a size above substantially 100,000 daltons out of said separated stream by flow of the separated stream through a porous medium having openings of a size adapted to pass molecules of a size less than substantially 100,000 daltons and to retain macromolecules of a size above substantially 100,000 daltons, and then returning the filtered separated stream substantially free of macromolecules of a size above substantially 100,000 daltons to the patient.
Claim 13
Independent Claim
127 words
A method of removing macromolecules from a stream of physiological solution removed directly from a patient including; forming from a stream of a patient's physiological solution a separated stream containing macromolecules including a size above substantially 100,000 daltons and substantially free of red blood cells, then using a membrane filter having a porosity to remove macromolecules of a size above substantially 100,000 daltons out of said separated stream by flow of the separated stream through a porous medium having openings of a size adapted to pass molecules of a size less than substantially 100,000 daltons and to retain macromolecules of a size above substantially 100,000 daltons, and then returning the filtered separated stream substantially free of macromolecules of a size above substantially 100,000 daltons to the patient.
Claim 14
Dependent Claim
26 words
The method of claim 9 and further including the step of pumping the physiological solution from the patient before it is formed into a separated stream.
Claim 15
Dependent Claim
25 words
A method as defined in claim 9 wherein said stream of physiological solution is blood, and said separated stream is plasma which includes said macromolecules.
Claim 16
Dependent Claim
23 words
A method as defined in claim 11, wherein the step of forming a separated stream removes macromolecules from below 0.2 microns effective diameter.
Claim 17
Dependent Claim
36 words
A method as defined in claim 12 wherein the step of forming a separated stream is effected with a porous membrane having a nominal pore size of 0.2 to 1.0 micron when filtering plasma from blood.
Claim 18
Dependent Claim
12 words
A method as defined in claim 13 wherein the process is continuous.
Claim 19
Independent Claim
94 words
A method of removing macromolecules from a stream of physiological solution removed directly from a patient including; forming from a stream of a patient's physiological solution a separated stream containing macromolecules, then using a membrane filter having a porosity to remove macromolecules of predetermined size out of said separated stream, and then returning the filtered separated stream substantially free of macromolecules of said predetermined size to the patient, and further including the step of adding a complexing agent to the separated stream before it is filtered by the membrane filter, said method being continuous.
Claim 20
Independent Claim
94 words
A method of removing macromolecules from a stream of physiological solution removed directly from a patient including; forming from a stream of a patient's physiological solution a separated stream containing macromolecules, then using a membrane filter having a porosity to remove macromolecules of predetermined size out of said separated stream, and then returning the filtered separated stream substantially free of macromolecules of said predetermined size to the patient, and further including the step of adding a complexing agent to the separated stream before it is filtered by the membrane filter, said method being continuous.
Claim 21
Independent Claim
137 words
A method of removing macromolecules from a stream of physiological solution removed directly from a patient including; forming from a stream of a patient's physiological solution a separated stream containing macromolecules, then using a membrane filter having a porosity to remove macromolecules of predetermined size out of said separated stream, then returning the filtered separated stream substantially free of macromolecules of said predetermined size to the patient, said stream of physiological solution being blood, and said separated stream being plasma which includes said macromolecules, and further including after the step of forming a separated stream containing said macromolecules and before using the membrane filter the step of cooling said separated stream to a temperature between about just above the freezing point of the separated stream and about 35° C. to cause such macromolecules to gel or precipitate.
Claim 22
Independent Claim
137 words
A method of removing macromolecules from a stream of physiological solution removed directly from a patient including; forming from a stream of a patient's physiological solution a separated stream containing macromolecules, then using a membrane filter having a porosity to remove macromolecules of predetermined size out of said separated stream, then returning the filtered separated stream substantially free of macromolecules of said predetermined size to the patient, said stream of physiological solution being blood, and said separated stream being plasma which includes said macromolecules, and further including after the step of forming a separated stream containing said macromolecules and before using the membrane filter the step of cooling said separated stream to a temperature between about just above the freezing point of the separated stream and about 35° C. to cause such macromolecules to gel or precipitate.
Claim 23
Independent Claim
112 words
A method of removing macromolecules from a stream of physiological solution removed directly from a patient including; forming from a stream of a patient's physiological solution, a separated stream containing macromolecules, then using a membrane filter having a porosity to remove macromolecules of predetermined size out of said separated stream, and then returning the filtered separated stream substantially free of macromolecules of said predetermined size to the patient, said membrane filter for removing the macromolecules out of the separated stream having a minimal porosity of nominally 0.01 to 0.2 microns to pass macromolecules of approximately 70,000 molecular weight and below and reject or collect macromolecules of approximately 100,000 molecular weight and over.
Claim 24
Independent Claim
112 words
A method of removing macromolecules from a stream of physiological solution removed directly from a patient including; forming from a stream of a patient's physiological solution, a separated stream containing macromolecules, then using a membrane filter having a porosity to remove macromolecules of predetermined size out of said separated stream, and then returning the filtered separated stream substantially free of macromolecules of said predetermined size to the patient, said membrane filter for removing the macromolecules out of the separated stream having a minimal porosity of nominally 0.01 to 0.2 microns to pass macromolecules of approximately 70,000 molecular weight and below and reject or collect macromolecules of approximately 100,000 molecular weight and over.
Claim 25
Independent Claim
135 words
An apparatus for removing macromolecules from a patient's physiological solution comprising; plasma separation means for dividing a physiological solution containing macromolecules into a concentrated cellular element stream and a plasma stream, a cooler in fluid flow communication with said plasma separation means for receiving the plasma stream therefrom and cooling such plasma stream to a predetermined temperature to cause the macromolecules therein to gel or precipitate, filter means in fluid flow communication with said cooling unit for receiving the cooled plasma stream therefrom and filtering such cooled plasma stream to remove macromolecules of a predetermined size therefrom, fluid flow communication means for receiving the filtered plasma stream from the filter means and for receiving the concentrated cellular element stream and combining said two last-named streams to form a processed stream for return to the patient.
Claim 26
Independent Claim
135 words
An apparatus for removing macromolecules from a patient's physiological solution comprising; plasma separation means for dividing a physiological solution containing macromolecules into a concentrated cellular element stream and a plasma stream, a cooler in fluid flow communication with said plasma separation means for receiving the plasma stream therefrom and cooling such plasma stream to a predetermined temperature to cause the macromolecules therein to gel or precipitate, filter means in fluid flow communication with said cooling unit for receiving the cooled plasma stream therefrom and filtering such cooled plasma stream to remove macromolecules of a predetermined size therefrom, fluid flow communication means for receiving the filtered plasma stream from the filter means and for receiving the concentrated cellular element stream and combining said two last-named streams to form a processed stream for return to the patient.
Claim 27
Dependent Claim
36 words
The structure of claim 18 and further including a pump in fluid flow communication with the plasma separation means and with the patient to pump the physiological solution from the patient to the plasma separation means.
Claim 28
Dependent Claim
27 words
The structure of claim 19 wherein a complexing agent is added to the plasma stream before it is filtered by the filter means to promote macromolecule formation.
Claim 29
Dependent Claim
11 words
The structure of claim 18 wherein said physiological solution is blood.
Claim 30
Dependent Claim
15 words
The structure of claim 21 wherein the separated plasma stream is blood plasma containing macromolecules.
Claim 31
Dependent Claim
14 words
The structure of claim 18 wherein the physiological solution is lymph or ascitic fluid.
Claim 32
Dependent Claim
33 words
The structure of claim 18 wherein said cooling unit cools the separated plasma stream to a temperature of between just above the freezing point of the separated plasma stream and approximately 35° centigrade.
Claim 33
Dependent Claim
13 words
The structure of claim 18 wherein said plasma separation means is a centrifuge.
Claim 34
Dependent Claim
14 words
The structure of claim 18 wherein said plasma separation means is a membrane filter.
Claim 35
Dependent Claim
51 words
The structure of claim 18 and further including a heater unit operatively secured to the fluid flow communication means at a point in such fluid flow communication means after said two last-named streams are combined to heat the processed stream to approximately body temperature before it is returned to the patient.
Claim 36
Independent Claim
149 words
An apparatus for removing macromolecules from a patient's physiological solution comprising; plasma separation means for dividing a physiological solution containing macromolecules into a concentrated cellular element stream and a plasma stream, a cooler in fluid flow communication with said plasma separation means for receiving the plasma stream therefrom and cooling such plasma stream to a predetermined temperature to cause the macromolecules therein to gel or precipitate, filter means in fluid flow communication with and encased in said cooling unit for receiving the cooled plasma stream therefrom and filtering and further cooling such cooled plasma stream to remove macromolecules of a predetermined size therefrom, fluid flow communication means for receiving the filtered plasma stream from the filter means and for receiving the concentrated cellular element stream and combining said two last-named streams to form a processed stream substantially free of macromolecules of said predetermined size for return to the patient.
Claim 37
Independent Claim
149 words
An apparatus for removing macromolecules from a patient's physiological solution comprising; plasma separation means for dividing a physiological solution containing macromolecules into a concentrated cellular element stream and a plasma stream, a cooler in fluid flow communication with said plasma separation means for receiving the plasma stream therefrom and cooling such plasma stream to a predetermined temperature to cause the macromolecules therein to gel or precipitate, filter means in fluid flow communication with and encased in said cooling unit for receiving the cooled plasma stream therefrom and filtering and further cooling such cooled plasma stream to remove macromolecules of a predetermined size therefrom, fluid flow communication means for receiving the filtered plasma stream from the filter means and for receiving the concentrated cellular element stream and combining said two last-named streams to form a processed stream substantially free of macromolecules of said predetermined size for return to the patient.
Claim 38
Dependent Claim
30 words
The structure of claim 28 wherein the cooler cools the plasma stream to a temperature of between just above the freezing point of the plasma stream and approximately 35° centrigrade.
Claim 39
Dependent Claim
51 words
The structure of claim 28 and further including a heater unit operatively secured to the fluid flow communication means at a point in such fluid flow communication means after said two last-named streams are combined to heat the processed stream to approximately body temperature before it is returned to the patient.
Claim 40
Independent Claim
151 words
An apparatus for removing macromolecules from a patient's physiological solution comprising; separation means for dividing a physiological solution containing macromolecules into a concentrated cellular element stream and a plasma stream, filter means in fluid flow communication with said plasma separation means for receiving the plasma stream therefrom and filtering such plasma stream to remove macromolecules of a size above substantially 100,000 daltons therefrom by flow of the plasma stream through said filter means which has openings of a size adapted to pass molecules of a size less than substantially 100,000 daltons and to retain macromolecules of a size above substantially 100,000 daltons, fluid flow communication means for receiving the filtered plasma stream from the filter means and for receiving the concentrated cellular element stream and combining said two last-named streams to form a processed stream substantially free of macromolecules of a size above substantially 100,000 daltons for return to the patient.
Claim 41
Independent Claim
151 words
An apparatus for removing macromolecules from a patient's physiological solution comprising; separation means for dividing a physiological solution containing macromolecules into a concentrated cellular element stream and a plasma stream, filter means in fluid flow communication with said plasma separation means for receiving the plasma stream therefrom and filtering such plasma stream to remove macromolecules of a size above substantially 100,000 daltons therefrom by flow of the plasma stream through said filter means which has openings of a size adapted to pass molecules of a size less than substantially 100,000 daltons and to retain macromolecules of a size above substantially 100,000 daltons, fluid flow communication means for receiving the filtered plasma stream from the filter means and for receiving the concentrated cellular element stream and combining said two last-named streams to form a processed stream substantially free of macromolecules of a size above substantially 100,000 daltons for return to the patient.
Claim 42
Independent Claim
128 words
An apparatus for removing macromolecules from a patient's physiological solution comprising; plasma separation means for dividing a physiological solution containing macromolecules into a concentrated cellular element stream and a plasma stream, filter means in fluid flow communication with said plasma separation means for receiving the plasma stream therefrom and filtering such plasma stream to remove macromolecules of a predetermined size therefrom, fluid flow communication means for receiving the filtered plasma stream from the filter means and for receiving the concentrated cellular element stream and combining said two last-named streams to form a processed stream substantially free of macromolecules of said predetermined size for return to the patient, a complexing agent being added to the plasma stream before it is filtered by the filter means to promote macromolecule formation.
Claim 43
Independent Claim
128 words
An apparatus for removing macromolecules from a patient's physiological solution comprising; plasma separation means for dividing a physiological solution containing macromolecules into a concentrated cellular element stream and a plasma stream, filter means in fluid flow communication with said plasma separation means for receiving the plasma stream therefrom and filtering such plasma stream to remove macromolecules of a predetermined size therefrom, fluid flow communication means for receiving the filtered plasma stream from the filter means and for receiving the concentrated cellular element stream and combining said two last-named streams to form a processed stream substantially free of macromolecules of said predetermined size for return to the patient, a complexing agent being added to the plasma stream before it is filtered by the filter means to promote macromolecule formation.
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| 3.5 Years (Year 4) | 1985-09-20 | 1986-03-22 | 1986-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-09-20 | 1990-03-22 | 1990-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-09-20 | 1994-03-22 | 1994-09-21 | $7700.00 | Window Closed / Lapsed |